DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and mei-218

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001027068.1	Gene:	mei-218 / 3772646	FlyBaseID:	FBgn0002709	Length:	1186	Species:	Drosophila melanogaster

Alignment Length:	386	Identity:	70/386 - (18%)
Similarity:	120/386 - (31%)	Gaps:	117/386 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 APSIHGHAYVKQAILC--------------------------------------------LLLGG 319
            |||.||..|.|..:.|                                            :||..
  Fly   804 APSQHGQEYPKPDLNCVPSSIKKLHHLISSQYSDYSFVYALSAQISQDCVPMDCFVYLKMILLAS 868

  Fly   320 VEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETG 384
            :..|  ....:|..|::.:|...|:..::||..|...|||.:     |....||...... ..|.
  Fly   869 IVSI--ESDEVRAPISLCIIATDSLMANRLLNKVGQLAPRFL-----GPHEYGLQPTFNA-LPTR 925

  Fly   385 ERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANP 449
            ...:.|..::||.:||....:::::|......:.:.:|.|.|.:.:..|...|.|....
  Fly   926 FNWIVASPLLLAQQGVYYAGDWNRLSKDQGCQLEKCIENGAVPVPQLHIDQPLKAAVWT------ 984

  Fly   450 VYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLS 514
                   |..| .|...|...|::...:|                               |.|:.
  Fly   985 -------YWQP-NNSTNQTLALAKLCPIF-------------------------------GLPIY 1010

  Fly   515 MGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQ 579
            ||:..::||.          ..:.:|::|  .|:........:..:.||..||:....|..|.:.
  Fly  1011 MGAQASNSLW----------NSIIQKHNA--EGQIVVNDGLSIPEDDMRMLIHLLHQRKTTLTDG 1063

  Fly   580 ACEAIANEYSRLRSQEAVETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAI 640
            |...:...|...|.:        |....:::|...|.:|:...|:..:...|...|...||
  Fly  1064 AQHMLQKYYVISRKE--------RPNVFSSKTYIVLKQLAECFAKLALRLEVLESDVCVAI 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	70/386 (18%)
mei-218	NP_001027068.1	PTZ00112	122..>417	CDD:240274
mei-218	NP_001027068.1	MCM	<1023..1116	CDD:278895	19/102 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11630
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010