DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm3 and mcm4

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_944595.2	Gene:	mcm4 / 337598	ZFINID:	ZDB-GENE-030131-9544	Length:	845	Species:	Danio rerio

Alignment Length:	694	Identity:	224/694 - (32%)
Similarity:	335/694 - (48%)	Gaps:	128/694 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EQFIKDIQREYVDFLD----DEEDQGIYAGHVKDMIAEKSKRL------IVNVN---------DL 51
            |:|    ||....|.|    :||:.|:...  :.:..:|...:      ::|||         ||
Zfish   146 EKF----QRFLQQFTDPDSREEENAGLDLN--EPLYMQKLDEISVVGEPVLNVNCTHIQTFDADL 204

  Fly    52 KRK---NPQRALGLLSNAADEQLAFGR---ALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTP 110
            .|:   .||..:.....:.:| |.|.|   ::.|:...|.|..|....::          |::.|
Zfish   205 YRQLICYPQEVIPTFDMSVNE-LFFDRFPDSVLEHQIQVRPYSAIKTRNM----------RNLNP 258

  Fly   111 RSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCP----NTRKVMERKYTDLTSFEAVPSGAAY 171
            ..     :..::.:.|:|.:.|.:.|::..:...|.    |||..::|            ...|.
Zfish   259 ED-----IDQLITISGMVIRTSQLIPEMQEAFFRCQVCAFNTRVEVDR------------GRIAE 306

  Fly   172 PTKDEDGNL---LETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQ 233
            |....:.|.   :...:..||:.|.|.:.:||.||..||||.|.:..:...:||||:.:|||||.
Zfish   307 PAVCRNCNTTHSMALVHNRSVFSDKQMIKLQESPEDMPAGQTPHTTVVYAHNDLVDKVQPGDRVN 371

  Fly   234 IVGSYRCLP---GKRGGYTSGTFRTVLLANNISLLSKE--SNLD-------ISREDIMLCKKLAK 286
            |.|.||..|   ..|.......::|.:.|.:.....::  ..||       .::|.:.|.|:||.
Zfish   372 ITGIYRAAPMRLNPRQSQVKSVYKTHIDAIHFRKTDEKRLHGLDEDGEQKLFTKERVALLKELAA 436

  Fly   287 NNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTR--LRGDINVLLIGDPSVAKSQL 349
            ..|::|.||.:|||||:.|..:|:.||..|.||..|......|  .|.::|:||.|||..:||||
Zfish   437 KPDVYERLSSALAPSIYEHEDIKKGILLQLFGGTRKDFTQTGRGNFRAEVNILLCGDPGTSKSQL 501

  Fly   350 LRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDR 414
            |:||.|..||...|:|:|||.|||||.|..|.||.:..|:.||:||:|.|:.||||||||||..|
Zfish   502 LQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMSDNTR 566

  Fly   415 TAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFV 479
            :.:||||||..::|:||||...||||.|:|||||||..:::..||.:|||.|..:|||||||:|:
Zfish   567 SVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPVESQWNPKKTTIENIQLPHTLLSRFDLIFL 631

  Fly   480 MLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDAL 544
            |||..|...|:.::.|:|.:: |::.::.:                    ||..|..|.:.|
Zfish   632 MLDPQDEAYDRRLAHHLVSLY-YQSEEQIE--------------------EEHLDMAVLKDY--- 672

  Fly   545 LHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITA 609
                          :.|.|..:|      |:|.|:|.:|:...|..:|...:....|: ..|
Zfish   673 --------------IAFARTTVH------PRLSEEASQALIEAYVDMRKIGSGRGMVS-AYP--- 713

  Fly   610 RTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLD 653
            |.||:||||:.|||:.|.|..|...|...|..|.:.|..:...|
Zfish   714 RQLESLIRLAEAHAKVRFSGKVETIDVEEAKRLHREALKQSATD 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	22/107 (21%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	197/562 (35%)
mcm4	NP_944595.2	MCM_N	147..269	CDD:291233	27/143 (19%)
		MCM	249..752	CDD:214631	197/577 (34%)
		P-loop_NTPase	487..626	CDD:304359	80/138 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820