Protein Alignment Mcm3 and Mcm6

DIOPT Version :10

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Alignment Length: 767
• Identity: 223/767 - (29%)
• Similarity: 355/767 - (46%)
• Gaps: 147/767 - (19%)

  Fly     2 AHEGEQFIKD-----IQREYVDFLDDEEDQG--IYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRA 59
            |..|:..:||     .|:.:.|||::.::.|  .|......:.:.....|.|:..|:::.:...|
  Fly     6 AQVGQLRVKDEVGIRAQKLFQDFLEEFKEDGEIKYTRPAASLESPDRCTLEVSFEDVEKYDQNLA 70

  Fly    60 LGLLSNAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPRSLTSIYLGNMVCV 124
            ..::...........:::..|..  |....|..:|.:|.|.. ...||.. |.||:..:|.::.:
  Fly    71 TAIIEEYYHIYPFLCQSVSNYVK--DRIGLKTQKDCYVAFTE-VPTRHKV-RDLTTSKIGTLIRI 131

  Fly   125 EGIVTKVSLIRPKVVRSVHYC----PNTRKVMER-KYTDLTSFEAVPSGAAYPT-KDEDGNLLET 183
            .|.|.:...:.|::|..|..|    ...|.|.:: |:|:       |:....|. .:....:|:.
  Fly   132 SGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQFKFTN-------PTICRNPVCSNRKRFMLDV 189

  Fly   184 EYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVG------------ 236
            |  .|::.|.|.:.|||...:.|.|.:||:|:|:...:||:..:.|||....|
  Fly   190 E--KSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTGTLIVVPDVSVLA 252

  Fly   237 --------SYRCLPG---------KRGGYTSGTFRTVLLANNISLLSKE---SNL---DISREDI 278
                    |.|..||         |..|.....:|...||.::...:..   ::|   :::.||:
  Fly   253 GVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGTDLPMSEVTAEDM 317

  Fly   279 MLCKK------------LAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLR 331
               ||            ::|:.::::.|..||.|||:|:..||:.||....|||.|.....|.||
  Fly   318 ---KKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAKTTTEKTSLR 379

  Fly   332 GDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLA 396
            |||||.::||||.||||.|:.|.:.:||||.|:|:.||..||||||..|:|:.:..:||||::||
  Fly   380 GDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFVIEAGALMLA 444

  Fly   397 DRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPM 461
            |.|:.||||||||...|:.||||.|||..::|::||:.|:||||.|:||||||:.||||:.|:..
  Fly   445 DNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPINGRYDRSKSLQ 509

  Fly   462 ENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFV 526
            :||.|...::|||||.|:::|..:..||..|:..:|.:|                       |.:
  Fly   510 QNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLH-----------------------SNI 551

  Fly   527 SSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRL 591
            ..|.|:..|                 .|::|      :|:..|:..||.:.::|...:...|..|
  Fly   552 EESVERAYT-----------------REEVL------RYVTFARQFKPVISQEAGHMLVENYGHL 593

  Fly   592 RSQEAVETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDR 656
            | |....|....|..||.|.||::||||.|.|:...|..|.......|..|:.    |.::..::
  Fly   594 R-QRDTGTSGRSTWRITVRQLESMIRLSEAMAKLECSNRVLERHVKEAFRLLN----KSIIRVEQ 653

  Fly   657 PSKR------------------RRNSGSDA--EDDNGEASSQRSPSRRSKRT 688
            |...                  ..|:|:.|  :::||..:|.....::.|.|
  Fly   654 PDIHLDDDEGLDMDDGIQHDIDMENNGAAANVDENNGMDTSASGAVQKKKFT 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	16/89 (18%)
		MCM	106..648	CDD:214631	193/594 (32%)
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	15/88 (17%)
		MCM	113..649	CDD:475121	194/599 (32%)
		MCM6_C	702..816	CDD:465688	2/4 (50%)