Protein Alignment Mcm3 and Mcm5

DIOPT Version :10

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001386133.1
• Gene: Mcm5 / 291885
• RGDID: 1306616
• Length: 734
• Species: Rattus norvegicus
• Alignment Length: 829
• Identity: 250/829 - (30%)
• Similarity: 376/829 - (45%)
• Gaps: 180/829 - (21%)

  Fly     2 AHEGEQFIKDIQREYVDFLDDEE---DQGIYAGHVKDMIAEKSKR--------LIVNVNDLKRKN 55
            |.||:.....:|:.:.:||....   |:..:....:|.:    ||        :.|.:.||...:
  Rat    21 AEEGQARKSHLQKRFKEFLRQYRVGTDRTGFTFKYRDEL----KRHYNLGEYWIEVEMEDLASFD 81

  Fly    56 PQRALGLLSNAADEQLAFGRALKEYASTVD---PGYAKMHEDLFVGFEGCFGNRHVTP---RSLT 114
            .:.|..|....|:.......|.||.|..|.   |...::.:|:.|..:.     ..:|   |.|.
  Rat    82 EELADYLYKQPAEHLQLLEEAAKEVADEVTRPRPAGDELLQDIQVMLKS-----DASPSSIRILK 141

  Fly   115 SIYLGNMVCVEGIVTKVSLIRPKVVR---SVHYCPNTRKVMERKYTDLTSFEAVP--SGAAYPTK 174
            |..:.::|.:.||:...|.:|.|..|   ....|.||          ||:....|  .|.|.|.|
  Rat   142 SDMMSHLVKIPGIIISASAVRAKATRISIQCRSCHNT----------LTNIAMRPGLEGYALPRK 196

  Fly   175 ---DEDGNLLETEYGLSVY---------KDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCK 227
               |:.|   ..:..|..|         .|.|||.:||:|:..|.|::||.:.:.||..|.|:..
  Rat   197 CNMDQAG---RPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVV 258

  Fly   228 PGDRVQIVGSY--------------RCLPGKRGGY---------TSGTFRTVLLANNISLLSKES 269
            ||:||.|:|.|              |...|.|..|         |.|:.|:  .|.::|...:|.
  Rat   259 PGNRVTIMGIYSIKKFGMNPSKGRDRVGVGIRSSYIRVLGIQVDTDGSGRS--FAGSVSPQEEEE 321

  Fly   270 NLDISREDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDI 334
                       .::||...:|:||:|:|::|||.|...:|:||.|||.||..|.||:|...||||
  Rat   322 -----------FRRLAALPNIYELVSRSVSPSIFGGMDMKKAIACLLFGGSRKRLPDGLTRRGDI 375

  Fly   335 NVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRG 399
            |:|::|||..||||||::|...:|..:.|:|:|||..||||:|..|..:....:|.|||||||.|
  Rat   376 NLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVIRDPSSRNFIMEGGAMVLADGG 440

  Fly   400 VVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENI 464
            ||||||||||.:.||.||||.|||..::|:||||..:||:|||||||||.|:||:|:.|.. :||
  Rat   441 VVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGE-DNI 504

  Fly   465 GLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSS 529
            ....::|||||::|::.|..:.:.|.|::.||:.:|                   ..:|:...:.
  Rat   505 DFMPTILSRFDMIFIVKDEHNEERDMMLAKHVITLH-------------------VSALTQTQAV 550

  Fly   530 EEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRS- 593
            |.:.|....:|:                 :.:.|     |:| .|:|..:|.|.:.|.|..:||
  Rat   551 EGEIDLAKMKKF-----------------IAYCR-----ARC-GPRLSAEAAEKLKNRYIIMRSG 592

  Fly   594 --QEAVETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDR 656
              |...:.|...:.|||.|.||.::|::.|.::.::....|..|...|:.|.|.:    .||...
  Rat   593 ARQHERDIDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVS----TLDAAL 653

  Fly   657 PSKRRRNSGSDAEDDNGEASSQRSPSRRSKR-TRTATVGADSDEEDIEPPQPDAGDLTRRETRRS 720
            ........|...::|      |...||..|: .|...:|:...|..|      ..|.|:::....
  Rat   654 SGNLSGVEGFTTQED------QEMLSRIEKQLKRRFAIGSQVSEHSI------VQDFTKQKYPEH 706

  Fly   721 LPARSVAMLMASPSSEEQSVATSTTEPAIISDARLGEFKNNLQR--LFR 767
             ..|.|..||                      .|.||.::.:||  |:|
  Rat   707 -AIRKVLQLM----------------------LRRGEIQHRMQRKVLYR 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	21/101 (21%)
		MCM	106..648	CDD:214631	201/587 (34%)
Mcm5	NP_001386133.1	MCM_N	32..130	CDD:464206	21/101 (21%)
		MCM	133..649	CDD:214631	201/588 (34%)