DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and mcm5

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_848523.2	Gene:	mcm5 / 286747	ZFINID:	ZDB-GENE-021209-1	Length:	736	Species:	Danio rerio

Alignment Length:	726	Identity:	224/726 - (30%)
Similarity:	341/726 - (46%)	Gaps:	128/726 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 NVNDLKRKNPQRALGLLSNAADE---QLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHV 108
            :::|...|.|...|.||..||.|   ::...|.:.|  .||......:..|.          ...
Zfish    84 DLSDCLYKLPSENLPLLEEAAQEVADEVTRPRPVGE--ETVQDIQVMLKSDA----------HPA 136

  Fly   109 TPRSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVP-----SG 168
            :.|||.|..:..:|.:.||:...:.:|.|..|....|...|.|:..          :|     .|
Zfish   137 SIRSLKSEQVSRLVKIPGIIISSTAVRAKATRVCLQCRGCRAVISN----------IPLPPGLQG 191

  Fly   169 AAYPTK---DEDGNL---LETEYGL---SVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVD 224
            .|.|.|   ::.|.:   ::..:.:   .|..|.||..:||.|:..|.|::||.:.:.||..|.|
Zfish   192 YALPRKCNTEQAGRVKCPVDPYFIIPDRCVCVDFQTQRLQEAPDAVPHGEMPRHMQLYCDRYLCD 256

  Fly   225 RCKPGDRVQIVGSY---RCLPGKRGGYTSGT--------FRTVLLANNISLLSKESNLDISREDI 278
            |..||:||.::|.|   :....|..|...||        .|.|.:..:.....:.:...:|.::.
Zfish   257 RVVPGNRVTVMGIYSIKKVAQTKAKGRDKGTGVGIRSAYLRVVGIDVDTEGAGRGATGSVSPQEE 321

  Fly   279 MLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPS 343
            ...:.||.:..:::.|::||||||:|...:|:||.|||.||..|.||:|...|||||:|::|||.
Zfish   322 EELRSLAASPSVYDSLARSLAPSIYGSDDLKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPG 386

  Fly   344 VAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDK 408
            .||||||::|...:|..:.|:|:|||..||||:|..|..|....:|.|||||||.||||||||||
Zfish   387 TAKSQLLKFVERCSPIGVYTSGKGSSAAGLTASVLRDPTTRGFVMEGGAMVLADGGVVCIDEFDK 451

  Fly   409 MSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSR 473
            |.:.||.||||.|||..::|:||||..:||:|||||||||.|:||:|..|.. :||....::|||
Zfish   452 MREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDDTKGE-DNIDFMPTILSR 515

  Fly   474 FDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVY 538
            ||::|::.|..|...|..::.||:.:|                         :|:..:.:..|
Zfish   516 FDMIFIIKDHHDQQRDMTLARHVMNVH-------------------------LSAQTQTEGVE-- 553

  Fly   539 EKYDALLHGKSRQRHEKILSVEFMRKYIHIA--KCMKPKLGEQACEAIANEYSRLRS---QEAVE 598
                    |:        :.:..::|||..:  || .|:|...|.|.:.|.|..:||   :...|
Zfish   554 --------GE--------IPLATLKKYIAYSRVKC-GPRLSAAAAEKLKNRYVLMRSGAKEHERE 601

  Fly   599 TDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRRN 663
            ||...:.|||.|.||.::|::.:.|:.::......::...|:.|.|.:    .||..........
Zfish   602 TDRRVSIPITVRQLEAVVRIAESLAKMKLQPIAGEEEVDEALRLFQVS----TLDAALSGSLSGV 662

  Fly   664 SGSDAEDDNGEASSQRSPSRRSKR-TRTATVGADSDEEDI-----EPPQPD------------AG 710
            .|...::|      |...||..|: .|...:|:...|..|     :...|:            .|
Zfish   663 EGFTTQED------QEMISRIEKQLKRRFAIGSQVSEHSIIQDFAKQKYPEHAIQKVLYLMLRRG 721

  Fly   711 DLTRRETRRSL 721
            :|..|..|:.|
Zfish   722 ELQHRMQRKVL 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	14/56 (25%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	192/571 (34%)
mcm5	NP_848523.2	MCM_N	35..154	CDD:291233	19/81 (23%)
		MCM	134..651	CDD:214631	192/575 (33%)
		AAA	378..522	CDD:99707	82/144 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820