DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mcm3 and MCM9

DIOPT Version :10

Sequence 1:NP_511048.2 Gene:Mcm3 / 31449 FlyBaseID:FBgn0284442 Length:819 Species:Drosophila melanogaster
Sequence 2:NP_060166.2 Gene:MCM9 / 254394 HGNCID:21484 Length:1143 Species:Homo sapiens


Alignment Length:918 Identity:228/918 - (24%)
Similarity:382/918 - (41%) Gaps:239/918 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 HVKDMIAEKSKR-------LIVNVNDLKRKNPQRALGLLSNAADEQL--AFGRALKEYASTV--- 84
            |..|::....:|       ::||...|...|.:  :|...|....::  .|..||:..|.|:   
Human    21 HKNDILLILKERDEDAHYPVVVNAMTLFETNME--IGEYFNMFPSEVLTIFDSALRRSALTILQS 83

  Fly    85 --DPGYAKMHEDLFVGFEG---C--FGNRHVTPRSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSV 142
              .|....|.::|.....|   |  ....|: |::..   :|:.:.|.|.|.:.||::.......
Human    84 LSQPEAVSMKQNLHARISGLPVCPELVREHI-PKTKD---VGHFLSVTGTVIRTSLVKVLEFERD 144

  Fly   143 HYCPNTRKV------MERKYT-------------DLTSFEAVPSGAAYPTKDEDGNLLETEYGLS 188
            :.|...:.|      .|:.||             |.:.|..:...::.||:              
Human   145 YMCNKCKHVFVIKADFEQYYTFCRPSSCPSLESCDSSKFTCLSGLSSSPTR-------------- 195

  Fly   189 VYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVG-----------SYRCLP 242
             .:|:|.:.|||..::...|.:|||:.::.:|||||.||.||.:.|.|           ..||  
Human   196 -CRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGIVMQRWKPFQQDVRC-- 257

  Fly   243 GKRGGYTSGTFRTVLLANNISLLSKESNLDISREDIMLCKKLAKNNDIFE-----------LLSK 296
                     ....||.||.|.:.:::|:..|..|::.     .:..|.:|           ::..
Human   258 ---------EVEIVLKANYIQVNNEQSSGIIMDEEVQ-----KEFEDFWEYYKSDPFAGRNVILA 308

  Fly   297 SLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAI 361
            ||.|.:.|...||.|:..:|.||:::....|||:||:.::||:|||...|||.|:|.....||::
Human   309 SLCPQVFGMYLVKLAVAMVLAGGIQRTDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSV 373

  Fly   362 PTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRV 426
            .|||.||:..|||  ||..:::||..|||||:||||.|:.|||||:.:.:.|||:|||.|||..:
Human   374 LTTGIGSTSAGLT--VTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTI 436

  Fly   427 TISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQM 491
            :::|||:...||.|.::|||.|| .|:||..::...||.|...|||||||:.|:||..:.|.|::
Human   437 SVAKAGLVCKLNTRTTILAATNP-KGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRI 500

  Fly   492 ISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKI 556
            ||..::         |..|.|                                      .:.||:
Human   501 ISSFIL---------ENKGYP--------------------------------------SKSEKL 518

  Fly   557 LSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITARTLETLIRLSTA 621
            .|:|.|:.|..:.:.::|.|.:...:.:...|...|..:.  .:.|||   |.|.||:||||:.|
Human   519 WSMEKMKTYFCLIRNLQPTLSDVGNQVLLRYYQMQRQSDC--RNAART---TIRLLESLIRLAEA 578

  Fly   622 HARARMSKSVTIDDAHAAIELVQFAY------------------------------------FKK 650
            |||.....:||::||...:.:::.:.                                    .:.
Human   579 HARLMFRDTVTLEDAITVVSVMESSMQGGALLGGVNALHTSFPENPGEQYQRQCELILEKLELQS 643

  Fly   651 VLDKD-RPSKRRRNSG---------------SDAEDDNGEASSQRSPSRR--SKRTRTATVGADS 697
            :|.:: |..:|.:|..               ....:..||.|:.|:.|::  :..|...:.|...
Human   644 LLSEELRRLERLQNQSVHQSQPRVLEVETTPGSLRNGPGEESNFRTSSQQEINYSTHIFSPGGSP 708

  Fly   698 DEEDIEPPQPDAGDLTRRETRRSLPARSVAM-------------LMASPSSEEQSVATSTTEPAI 749
            :...:..|.|      ..|..||...:..|.             .||:..||.::....:..|..
Human   709 EGSPVLDPPP------HLEPNRSTSRKHSAQHKNNRDDSLDWFDFMATHQSEPKNTVVVSPHPKT 767

  Fly   750 ISDARLGEFKNNLQRLFREAREQSLALARITTAINVG-------SQEPFTAGEIEA-AVHRMTED 806
            ..:....:..|:..    :.:|:|....|  :.:::|       :..|:.|..:|: ...|:..|
Human   768 SGENMASKISNSTS----QGKEKSEPGQR--SKVDIGLLPSPGETGVPWRADNVESNKKKRLALD 826

  Fly   807 NQIMVADD 814
            ::..|:.|
Human   827 SEAAVSAD 834

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mcm3NP_511048.2 MCM_N 13..101 CDD:464206 17/82 (21%)
MCM 106..648 CDD:214631 175/618 (28%)
MCM9NP_060166.2 Mcm2 2..605 CDD:440854 194/675 (29%)
MCM9 305..603 CDD:350666 126/352 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 656..738 14/87 (16%)
PTZ00449 <751..1113 CDD:185628 15/90 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 755..815 8/65 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 868..916
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 942..1011
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1063..1105
Blue background indicates that the domain is not in the aligned region.

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