Protein Alignment Mcm3 and mcm5

DIOPT Version :10

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001342928.1
• Gene: mcm5 / 2542477
• PomBaseID: SPAC1B2.05
• Length: 720
• Species: Schizosaccharomyces pombe
• Alignment Length: 686
• Identity: 229/686 - (33%)
• Similarity: 340/686 - (49%)
• Gaps: 121/686 - (17%)

  Fly     1 MAHEGEQFIKDIQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLSN 65
            ::|| :.||:.|:...:|      :..||...::|.:..|...|.:::..|...|...|..|||.
pombe    28 VSHE-KNFIQFIEEFVID------NDFIYRTQLRDNLVVKQYMLNIDLRHLISYNEDLAHLLLSQ 85

  Fly    66 AADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGC----FGNRHVTP-RSLTSIYLGNMVCVE 125
            ..|....|..|:...|..:   ..:..|:.......|    ..:.::.| |:||:.::..:|.|.
pombe    86 PTDILPLFESAVTTVAKRL---LYRSQENASTNIPTCQVTLRYDANILPIRNLTASHISKLVRVP 147

  Fly   126 GIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVPSGAAYPTKDE----DGNLLE---- 182
            ||:...|.:..:.......|.|.|.      |.:.......||...|...|    ||...:
pombe   148 GIIIGASTLSCRATALHLVCRNCRA------TRILQISGGFSGVQLPRVCEAPVLDGEKKDCPMD 206

  Fly   183 ---TEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLPGK 244
               .::..|.:.|.|.|.:||.|:..|.|:|||.:.:..|..|.::..||.|..|.|.:.....|
pombe   207 PFIIDHSKSTFIDQQVLKLQEAPDMVPVGELPRHILLNADRYLTNQITPGTRCVITGIFSIFQNK 271

  Fly   245 ----------RGGY----------TSGTFRTVLLANNISLLSKESNLDISREDIMLCKKLAKNND 289
                      |..|          ..|:..|.|.:..    .:|..|:|||           ..:
pombe   272 SVKASGAVAIRNPYIRVVGIQMDSNDGSKSTPLFSEE----EEEEFLEISR-----------TPN 321

  Fly   290 IFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVL 354
            :::::|.|::|:|:|:..:|:||.|||..|.:||||:|.||||||||||:|||..||||.|::|.
pombe   322 LYDIISNSISPAIYGNVDIKKAIACLLFSGSKKILPDGMRLRGDINVLLLGDPGTAKSQFLKFVE 386

  Fly   355 NTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHE 419
            ..||.|:.|:|:|||..||||::..|..|.|..||.|||||||.|:|||||||||.|.||.||||
pombe   387 RLAPIAVYTSGKGSSAAGLTASIQRDSVTREFYLEGGAMVLADGGIVCIDEFDKMRDEDRVAIHE 451

  Fly   420 VMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVI 484
            .|||..::|:||||...||:|.||||||||::||||..|||.|||..|.::|||||::|::.|..
pombe   452 AMEQQTISIAKAGITTILNSRTSVLAAANPIFGRYDDMKTPGENIDFQSTILSRFDMIFIVKDEH 516

  Fly   485 DSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEV-YEKYDALLHGK 548
            |...|:.|:.||:.:|  .|.:|: .|.|::|                   |: ::|:
pombe   517 DETKDRNIARHVINLH--TNLQES-SETLAIG-------------------EIPFDKF------- 552

  Fly   549 SRQRHEKILSVEFMRKYIHIA--KCMKPKLGEQACEAIANEYSRLRS---QEAVETDVARTQPIT 608
                          |:||:..  || .|.|..:|.|.:::::..:|.   |...:::...|.|||
pombe   553 --------------RRYINYCRHKC-APNLDAEAAEKLSSQFVAIRKRVHQSEQDSNSRSTIPIT 602

  Fly   609 ARTLETLIRLSTAHARARMSKSVTIDDAHA--AIEL 642
            .|.||.:||::  .:.|:||.|....:|||  ||.|
pombe   603 VRQLEAIIRIT--ESLAKMSLSPIASEAHATEAIRL 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	17/87 (20%)
		MCM	106..648	CDD:214631	206/577 (36%)
mcm5	NP_001342928.1	MCM_N	34..124	CDD:464206	21/98 (21%)
		MCM	128..642	CDD:214631	206/576 (36%)