DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm3 and mcm3

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_587795.1	Gene:	mcm3 / 2538838	PomBaseID:	SPCC1682.02c	Length:	879	Species:	Schizosaccharomyces pombe

Alignment Length:	889	Identity:	413/889 - (46%)
Similarity:	557/889 - (62%)	Gaps:	91/889 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EQFIKD---IQREYVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLSNAA 67
            ::..||   |.:||::...|:.:..:|...:..|:....:|||||:::|:..|.:.|.|:|....
pombe     7 DEVFKDRVRIFQEYLEHDTDDANVTLYQEAILRMLNMGQRRLIVNIDELRDYNRELADGVLLKPL 71

  Fly    68 DEQLAFGRALKEYAST-VDPGYAKMHEDL-----FVGFEGCFGNRHVTPRSLTSIYLGNMVCVEG 126
            :....|..||:...|| :||   .:|:||     :|||.|.||:.||.||:|.:::|..|:.:||
pombe    72 EYVEPFDEALRNVVSTLIDP---VVHKDLKDKLFYVGFRGSFGDHHVNPRTLRAMHLNKMISLEG 133

  Fly   127 IVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLT-----SFEAVPSGAAYPTKDEDGNLLETEYG 186
            |||:.|.:||||::|||||..|::...::|.|.|     ||::    ..|||:||:||.|..|:|
pombe   134 IVTRCSFVRPKVIKSVHYCEATKRHHFKQYADATMNGGLSFQS----TVYPTQDENGNPLSIEFG 194

  Fly   187 LSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLPGKRGGYTSG 251
            .|.::|||::::|||||:||.||||||:||:.||||||..||||||.|||.||.:..|..|.||.
pombe   195 FSTFRDHQSISLQEMPERAPPGQLPRSIDILLDDDLVDTVKPGDRVNIVGQYRSMGSKTSGNTSA 259

  Fly   252 TFRTVLLANNISLLSKESN--------LDISREDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYV 308
            ||||||||||:.||..:..        |||:..||....|||:..::|||||.||||||:|:.||
pombe   260 TFRTVLLANNVVLLGNKPGLGNVGGGALDITDADIRNINKLARKKNVFELLSTSLAPSIYGYEYV 324

  Fly   309 KQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGL 373
            |||||.|||||.||.|.|||.:|||||:|::||||.|||||||:||||||.||.|||||||||||
pombe   325 KQAILLLLLGGTEKNLTNGTHIRGDINILMVGDPSTAKSQLLRFVLNTAPLAIATTGRGSSGVGL 389

  Fly   374 TAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLN 438
            |||||||:|||||||||||||||||||||||||||||||||.||||||||..|||:|||||.|||
pombe   390 TAAVTTDKETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRVAIHEVMEQQTVTIAKAGIHTSLN 454

  Fly   439 ARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYR 503
            |||||:|||||:||:||..|.|.:||.|.||:||||||||::.|.||...|:.:|:||:|||||.
pombe   455 ARCSVIAAANPIYGQYDIRKDPHQNIALPDSMLSRFDLLFIVTDDIDDKKDRALSEHVLRMHRYL 519

  Fly   504 NPKEADGEP--------LSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVE 560
            .|....|.|        |::|::.|..:| ..:.|::.:|.|:|.:.:|||..:|.:.:::|::.
pombe   520 PPGVEPGTPVRDSLNSVLNVGATNAAGVS-TENVEQEVETPVWETFSSLLHANARTKKKELLNIN 583

  Fly   561 FMRKYIHIAKC-MKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITARTLETLIRLSTAHAR 624
            |:||||..||. :.|.|.:...|.|.|.|..||:.: ::.:..||.|:||||||||||||||||:
pombe   584 FVRKYIQYAKSRIHPILNQATAEYITNIYCGLRNDD-LQGNQRRTSPLTARTLETLIRLSTAHAK 647

  Fly   625 ARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRP--SKRRRNSGS--DAEDDNG-----EASSQR- 679
            ||:|..|.:.||.||.:::::|.|::|:...|.  .|:|..:|.  |:||||.     |.|.:.
pombe   648 ARLSSVVEVKDAKAAEKILRYALFREVVKPKRKKHKKQRLEAGEEFDSEDDNSDDMDIEESEEEM 712

  Fly   680 -------SPSRRSKRTRTATVGADSDEEDIEPPQPDAG------------DLTRRETRRSLPARS 725
                   |.|||..|::.||  :.|.|...|.....||            .|:...|..:|||.|
pombe   713 DTNMVIDSGSRRVTRSQNAT--SQSQESGSEIGSSIAGTAGSYNVGTSNTQLSWPSTHSTLPATS 775

  Fly   726 VAMLMA--------------SPSSEEQSVATSTTEPAIISDARLGEFKNNLQRLFREAREQSLAL 776
            ..:..:              |.|..|||..:...|...:..|||.....:  .||   .|:..:|
pombe   776 RELASSDRNINTGTSVASEVSASVSEQSTVSLPREKMSVFMARLASLTKS--ELF---SEECASL 835

  Fly   777 ARITTAI-NVGSQEPFTAGEIEAAVHRMTEDNQIMVADDIVFLI 819
            ..:..:| |:.....|:..|...|:..|...|:||.:|::|:.|
pombe   836 EDVLESINNIEDDVGFSREEAIVALKEMDAQNKIMFSDNVVYRI 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	26/88 (30%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	323/563 (57%)
mcm3	NP_587795.1	MCM_N	17..133	CDD:291233	38/118 (32%)
		Mcm2	21..719	CDD:224162	365/706 (52%)
		P-loop_NTPase	<407..>465	CDD:304359	51/57 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	332	1.000	Domainoid score	I204
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1791
Inparanoid	1	1.050	677	1.000	Inparanoid score	I111
OMA	1	1.010	-	-		QHG53768
OrthoFinder	1	1.000	-	-		FOG0004045
OrthoInspector	1	1.000	-	-		oto101754
orthoMCL	1	0.900	-	-		OOG6_101598
Panther	1	1.100	-	-	LDO	PTHR11630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R693
SonicParanoid	1	1.000	-	-		X2791
TreeFam	1	0.960	-	-
	14	13.860