Protein Alignment Mcm3 and mcm2

DIOPT Version :10

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_775364.2
• Gene: mcm2 / 192338
• ZFINID: ZDB-GENE-020419-24
• Length: 889
• Species: Danio rerio
• Alignment Length: 790
• Identity: 256/790 - (32%)
• Similarity: 375/790 - (47%)
• Gaps: 140/790 - (17%)

  Fly     1 MAHEGEQFIKDIQ----------REYV--------------DFLD---DEEDQGIYAGHVKDMIA 38
            |..|.|:.|:.|:          ||:|              :||.   ||....::...:.||..
Zfish   148 MEGEDEEMIESIENLEDMKGHTVREWVSMAAPRLEIYHRFKNFLRTHVDEHGHNVFKERISDMCK 212

  Fly    39 EKSKRLIVNVNDLKRKNPQRALGLLSNAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCF 103
            |..:.|:||..:|..:....|..|....|:....|..|.||....:.|.|.::..::.|.    .
Zfish   213 ENKESLLVNYEELASREHVLAYFLPEAPAEMLKIFDEAAKEVVLAMYPKYDRIAHEIHVR----I 273

  Fly   104 GNRHVTP--RSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVP 166
            ||..:..  |||..::|..::...|:||..:.:.|::....:.|.....::
Zfish   274 GNLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLGMVKYNCNKCNFIL-------------- 324

  Fly   167 SGAAYPTKDED---GNL--------LETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDD 220
             |..:.:::::   |:.        .|.....:||:::|.:||||.|.|..||:||||.|.:...
Zfish   325 -GPFFQSQNQEVKPGSCPECQSLGPFEINMEQTVYQNYQRITIQESPGKVAAGRLPRSKDAILLA 388

  Fly   221 DLVDRCKPGDRVQIVGSYRCLPGKRGGYTSG--------TFRTVLLANNISLLSKESNL---DIS 274
            ||||.|||||.:::.|.|      ...|...        .|.||:|||:|:  .|:..:   :::
Zfish   389 DLVDMCKPGDEIELTGIY------HNNYDGSLNMANGFPVFATVILANHIA--RKDEGVAVAELT 445

  Fly   275 REDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGT-RLRGDINVLL 338
            .||:.....|:|:..|.|.:..|:.|||:.|..:|:.:...|.||..| .|.|. ::||||||||
Zfish   446 DEDVKAIVALSKDERIGERIFASIGPSIYAHEDIKRGLALALFGGEAK-NPGGKHKVRGDINVLL 509

  Fly   339 IGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCI 403
            .|||..||||.|:||...|.||:.|||:|:|.|||||.|.....:.|..|||||:|||||||..|
Zfish   510 CGDPGTAKSQFLKYVEKVASRAVFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLI 574

  Fly   404 DEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQD 468
            ||||||:|.|||:|||.|||..::||||||..||.|||:|:|||||:.||||...|..||:.|.:
Zfish   575 DEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTE 639

  Fly   469 SLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKK 533
            .::||||:|.|:.|.:|...|:|::..||..|...:|...:|.              |:..||
Zfish   640 PIISRFDVLCVVRDTVDPVQDEMLARFVVGSHIKHHPSNKEGG--------------VAGLEE-- 688

  Fly   534 DTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAK-CMKPKLGEQACEAIANEYSRLRSQEAV 597
             ..:...:|.           ..:..|.:||||..|| .::|||.:...:.:|..||.||.:...
Zfish   689 -VVLPNTFDV-----------PPIPQELLRKYIIYAKERVRPKLNQMDQDKVARIYSDLRKESMA 741

  Fly   598 ETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRR 662
            ...:    |||.|.:|::||::.||||..:...|..||.:.||.::    .:..:|..:.|..|.
Zfish   742 TGSI----PITVRHIESMIRMAEAHARMHLRDYVLEDDVNMAIRVM----LESFIDTQKFSVMRS 798

  Fly   663 NSGSDA-----EDDNGE---------ASSQRSPSRRSKRTRTATVGADSDEEDIEPPQPDAGDLT 713
            ...:.|     ..||.|         .|.|.|..|.       ..||..|  .||..:.|..|..
Zfish   799 MRKTFARYLAFRRDNNELLLFILKQLVSEQVSYQRN-------RYGAQQD--TIEIAEKDLVDKA 854

  Fly   714 RRETRRSLPA 723
            |:....||.|
Zfish   855 RQINIHSLSA 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	24/114 (21%)
		MCM	106..648	CDD:214631	203/567 (36%)
mcm2	NP_775364.2	MCM2_N	57..170	CDD:403724	5/21 (24%)
		MCM_N	185..273	CDD:464206	21/91 (23%)
		MCM	279..788	CDD:214631	203/568 (36%)