Protein Alignment Mcm3 and mcm-6

DIOPT Version :10

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001023011.1
• Gene: mcm-6 / 176385
• WormBaseID: WBGene00003158
• Length: 810
• Species: Caenorhabditis elegans
• Alignment Length: 766
• Identity: 226/766 - (29%)
• Similarity: 360/766 - (46%)
• Gaps: 189/766 - (24%)

  Fly    12 IQREYVDFL---DDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLSNAADEQLAF 73
            :|.|:..||   .|::::.||...:|:::..:...:.:|:..|.:         .||
 Worm    20 VQNEFSKFLKSFKDQKNEFIYKSAMKELVQPEKNTIFINMQHLYK---------FSN-------- 67

  Fly    74 GRALKEYASTVDPGYAKMH-------------------------EDLFVGFEGCFGNRHVTPRSL 113
                 ..|:|::..|.:::                         :.|:|..........|  |.|
 Worm    68 -----NLATTIELQYYRVYPFMCEALHLATLDACDESERQQMFKKQLYVSLFNLDAKTKV--REL 125

  Fly   114 TSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPN----TRKVMER-KYTDLTSFEAVPSGAAYPT 173
            ::..:|.:|.:.|.:.:...:.|::.|:...|.:    ||.|.:: :||.             ||
 Worm   126 SADKVGGLVRIAGQIVRTHPVHPELSRACFVCEDCGVTTRDVQQQFRYTQ-------------PT 177

  Fly   174 KDEDGNLL-ETEYGL----SVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQ 233
            |..:...: .|.:.|    |.:.|.|.:.|||...:.|.|.:||:||::...::|:..:|||:..
 Worm   178 KCANPQCMNRTRFSLDVNSSTFVDFQKIRIQETQAELPRGSIPRTVDVIVRGEMVETVQPGDKCD 242

  Fly   234 IVGSYRCLPG----------------KRG---------------GYTSGTFRTVLLANNI----S 263
            |||:...:|.                .||               |....|::...||.:|    |
 Worm   243 IVGTLIVIPDIAQLSTPGLRAETSNQNRGRATDKSEGITGLKALGVRDLTYKMAFLACHIQQTES 307

  Fly   264 LLSKESN--------LDI----SREDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLL 316
            |:..:::        ||:    |.||....||::.:..|.:.:..||.|:|:|:..||..:|.:|
 Worm   308 LVGGDASGAVEETDYLDLWSKMSTEDRATLKKMSDDKKIEKNIVDSLFPNIYGNHEVKLGVLLML 372

  Fly   317 LGGV-EKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTD 380
            |||| :|....||.|||||||.|:||||.||||:|:.|...:||||.|:|:.||..||||||..|
 Worm   373 LGGVAKKSRDEGTSLRGDINVCLVGDPSTAKSQVLKAVEEFSPRAIYTSGKASSAAGLTAAVVKD 437

  Fly   381 QETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLA 445
            :|:.|..:||||::|||.||.||||||||...|:.||||.|||..::|:|||:.|:||||.|:||
 Worm   438 EESFEFVIEAGALMLADNGVCCIDEFDKMDLKDQVAIHEAMEQQTISITKAGVKATLNARASILA 502

  Fly   446 AANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADG 510
            |||||.||||:.:....|:.:...::|||||.||::|..:...|..|:..::..||
 Worm   503 AANPVNGRYDRSRPLKYNVQMSAPIMSRFDLFFVLVDECNEVTDYAIARRILDNHR--------- 558

  Fly   511 EPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPK 575
                            :.||..:...||:                   ::.::|||..|:|.|||
 Worm   559 ----------------AISEHTERDSVYK-------------------IDDIKKYIAFARCFKPK 588

  Fly   576 LGEQACEAIANEYSRLRSQEAVETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAI 640
            :.::|.|.:..||.:||..:: ......:..||.|.||:|:|||.|.||....|.|.::....|.
 Worm   589 ISDKAAETLVREYKKLRMSDS-NNAATSSWRITVRQLESLVRLSEALARLHCGKEVLVEHVEKAA 652

  Fly   641 ELVQFAYFK-----------------KVLDKDRPSKRRRNSGSDAEDDNGE 674
            ||:..:..:                 .|::.|:.::|    |.|:.|.:||
 Worm   653 ELLNKSIVRVEQPDIALDDDDFDNNIMVVEADKENQR----GDDSMDHDGE 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	17/115 (15%)
		MCM	106..648	CDD:214631	201/599 (34%)
mcm-6	NP_001023011.1	MCM_N	21..115	CDD:464206	17/115 (15%)
		MCM	119..660	CDD:214631	201/600 (34%)
		MCM6_C	710..807	CDD:465688