DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and mcm-2

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001022416.1	Gene:	mcm-2 / 174841	WormBaseID:	WBGene00003154	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	679	Identity:	239/679 - (35%)
Similarity:	357/679 - (52%)	Gaps:	58/679 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EQFIKDIQREYVDFLDDEEDQG----IYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALG-LLSN 65
            |...|:|:|.:.:||....:.|    .|...:|.|.|:..:.|.|:..||...|.::.:. .|..
Worm   162 EAVAKEIERRFKNFLRSFHEPGNKQTKYIQMIKSMAADNRESLEVSFTDLSDDNGEQNISYFLPE 226

  Fly    66 AADEQLA-FGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPRSLTSIYLGNMVCVEGIVT 129
            |.:|.|| ..||..|....:.|.|:::..::.|..........:  |.|..::|..::...|:||
Worm   227 APNEMLAIMDRAATEVVMNMYPFYSRVCNEIKVRISQLPVEEDI--RMLRQVHLNMLIRTAGVVT 289

  Fly   130 KVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVPSGAAYPTKDEDGNLLETEYGLSVYKDHQ 194
            ..|.|.|::....:.|.....:: ..:......|..|:  ..|:....|. .|.....:||.::|
Worm   290 IASGILPQLAVVKYDCVACGYLL-GPFVQQNDEEVRPT--ICPSCQGKGP-FELNVENTVYHNYQ 350

  Fly   195 TLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLPGKRGGYTSG--TFRTVL 257
            .:|:||.|.|..||:||||.|::...||.|.|||||.:::.|.|.........|..|  .|.|::
Worm   351 RITMQESPNKVAAGRLPRSKDVILLGDLCDSCKPGDEIEVTGVYTNNFDGSLNYKQGFPVFNTLI 415

  Fly   258 LANNISLLSKESNLDISREDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEK 322
            .||:|:...|.::..::.|||...::|:::.:|.:.:..|:||||:||..||:||...|..|..|
Worm   416 HANHITNKDKMASDQLTDEDIKAIRELSQDPNISQRVFSSIAPSIYGHDDVKRAIALALFRGEAK 480

  Fly   323 ILPNGTRLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERR 387
            ......||||||||||.|||..||||.|||..:.|||::.|||:|:|.|||||.|.....|.|..
Worm   481 NPGAKHRLRGDINVLLCGDPGTAKSQFLRYAAHIAPRSVLTTGQGASAVGLTAYVQRHPVTREWT 545

  Fly   388 LEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYG 452
            ||||||||||:||..|||||||||.|||:|||.|||..::||||||..||:|||:|:||:||:.|
Worm   546 LEAGAMVLADKGVCLIDEFDKMSDQDRTSIHEAMEQQSISISKAGIVTSLHARCTVIAASNPIGG 610

  Fly   453 RYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGS 517
            ||:..:|..||:.|.:.:|||||:|.|:.|.:||..|:.::..||..||..:|
Worm   611 RYNPTRTFAENVDLTEPILSRFDVLCVIRDSVDSVEDERLAKFVVGNHRTHHP------------ 663

  Fly   518 SYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIA--KCMKPKLGEQA 580
               |:...|...:|.::.::.|:...           :::..:.:||||..|  || .|.|.||.
Worm   664 ---DAKKIVKEGDELEEDQMDERTGV-----------RLIPQDLLRKYIIYAREKC-HPTLPEQH 713

  Fly   581 CEAIANEYSRLRSQEAVETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQF 645
            .|..:|.::::|.:......||    ||.|.:|::||||.|||:..:...|..:|..|||.::..
Worm   714 SEKFSNIFAQMRKESMATGSVA----ITVRHVESMIRLSEAHAKLHLRSYVNDEDCAAAIRVMLE 774

  Fly   646 AY-----------FKKVLDKDRPSKRRRN 663
            ::           .||...:.....|..|
Worm   775 SFVNTQKASIMRMMKKTFSRHLTENRSAN 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	23/88 (26%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	208/556 (37%)
mcm-2	NP_001022416.1	MCM2_N	48..>103	CDD:289392
		MCM_N	171..286	CDD:291233	26/116 (22%)
		MCM	270..777	CDD:214631	208/543 (38%)
		AAA	461..639	CDD:99707	105/177 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920