Protein Alignment Mcm3 and Mcm7

DIOPT Version :9

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_032594.1
• Gene: Mcm7 / 17220
• MGIID: 1298398
• Length: 719
• Species: Mus musculus
• Alignment Length: 698
• Identity: 235/698 - (33%)
• Similarity: 353/698 - (50%)
• Gaps: 115/698 - (16%)

  Fly     5 GEQFIKDIQRE----YVDFLDDEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLSN 65
            |.|.:....||    |||..|..||.    ..:.|.|.|.:||......|:.::       ||..
Mouse    34 GTQLVHLAHREQVALYVDLDDIAEDD----PELVDSICENAKRYSRLFGDVVQE-------LLPE 87

  Fly    66 AADEQLAFGRALKEYAS--------TVDPGYAKMHE-----DLFVGFEGCF-GNRHVTPRSLTSI 116
            ..::::.....|..|..        :.|||..:..:     :|...||..| |.....||.:..:
Mouse    88 YKEKEVVNKDVLDVYIEHRLMMEQRSRDPGAVRNPQNQYPSELMRRFELYFRGPSSSKPRVIREV 152

  Fly   117 ---YLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVPSGAAYP------ 172
               .:|.::.|.||||:||.::|::|.:.:.|..         ....:::.:.|....|
Mouse   153 RADSVGKLLTVRGIVTRVSEVKPRMVVATYTCDQ---------CGAETYQPIQSPTFMPLIMCPS 208

  Fly   173 ----TKDEDGNLLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQ 233
                |....|.|.....| |.:...|.:.|||..::.|.|.:|||:.:|.:.:.....:|||.|.
Mouse   209 QECQTNRSGGRLYLQTRG-SKFVKFQEMKIQEHSDQVPVGNIPRSITVVLEGENTRIAQPGDHVS 272

  Fly   234 IVGSYRCLPGKRGGY---TSGTF-RTVLLANNISLLSKESN-----LDISREDIMLCKKLAKNND 289
            :.|.:  ||..|.|:   ..|.. .|.|.|:.|..::|..:     .::|.|::   |::|: .|
Mouse   273 VTGIF--LPVLRTGFQQMAQGLLSETYLEAHWIVKMTKSDDDVSGAGELSSEEL---KQIAE-ED 331

  Fly   290 IFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIGDPSVAKSQLLRYVL 354
            .:|.|:.|:||.|:||..||:|:|.||:|||:: .|.|.::||:|::.|:|||.|||||||.|:.
Mouse   332 FYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQ-SPQGMKIRGNIHICLMGDPGVAKSQLLSYID 395

  Fly   355 NTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHE 419
            ..|||:..|||||||||||||||..|..:||..||.||:||||:||.||||||||::.|||||||
Mouse   396 RLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHE 460

  Fly   420 VMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVI 484
            ||||..::|:||||..:||||||:||||||.||||:..::..:|:.|..:||||||||:::.|..
Mouse   461 VMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNVQLPAALLSRFDLLWLIQDRP 525

  Fly   485 DSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKS 549
            |.|.|..::.|:..:|::.....|..|||.|
Mouse   526 DRDNDLRLAQHITYVHQHSRQPPAQFEPLDM---------------------------------- 556

  Fly   550 RQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITARTLET 614
                      :.||:||.:....:|.:.|...:.|...|..:|.:.....|...|   :||||..
Mouse   557 ----------KLMRRYIAMCHERQPTVPESLADYITAAYVEMRREARASKDATYT---SARTLLA 608

  Fly   615 LIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRR 662
            ::|||||.||.||...|..:|.:.||.|::.:....:.:|.:.::.:|
Mouse   609 ILRLSTALARLRMVDIVEKEDVNEAIRLMEMSKDSLLGEKGQTARTQR 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	19/95 (20%)
		MCM	106..648	CDD:214631	205/563 (36%)
Mcm7	NP_032594.1	MCM_N	12..165	CDD:291233	32/141 (23%)
		MCM	145..641	CDD:214631	205/559 (37%)
		P-loop_NTPase	376..515	CDD:304359	88/138 (64%)
		Arginine finger	513..516		2/2 (100%)
		Interaction with RAD17. /evidence=ECO:0000250	521..564		14/86 (16%)
		Interaction with ATRIP. /evidence=ECO:0000250	577..719		25/83 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820