Protein Alignment Mcm3 and Mcm4

DIOPT Version :10

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_032591.3
• Gene: Mcm4 / 17217
• MGIID: 103199
• Length: 862
• Species: Mus musculus
• Alignment Length: 855
• Identity: 243/855 - (28%)
• Similarity: 376/855 - (43%)
• Gaps: 196/855 - (22%)

  Fly     6 EQFIKDIQREYVDFLDDEED-------QGIYAGHVKDMIAEKSKRLIVNVNDLK--RKN------ 55
            |.|.:.:|. :.|.|..||:       |.:|...:.::.......|.||...:|  .||
Mouse   163 ENFQRFLQC-FTDPLAKEEENVGIDITQPLYMQQLGEINITGEPFLNVNCEHIKSFSKNLYRQLI 226

  Fly    56 --PQRALGLLSNAADEQLAFGR---ALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPRSLTS 115
              ||..:.....|.:| :.|.|   ::.|:...|.|..|...:.:          |::.|..
Mouse   227 SYPQEVIPTFDMAVNE-IFFDRYPDSILEHQIQVRPFNALKTKSM----------RNLNPED--- 277

  Fly   116 IYLGNMVCVEGIVTKVSLIRPKVVRSVHYCP----NTRKVMERKYTDLTSFEAVPSGAAYPTKDE 176
              :..::.:.|:|.:.|.:.|::..:...|.    .||..::|...      |.|....:.....
Mouse   278 --IDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEIDRGRI------AEPCSCVHCHTTH 334

  Fly   177 DGNLLETEYGLSVYKDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCL 241
            ...|:   :..|.:.|.|.:.:||.||..||||.|.::.:...:||||:.:|||||.:.|.||.:
Mouse   335 SMALI---HNRSFFSDKQMIKLQESPEDMPAGQTPHTIVLFAHNDLVDKVQPGDRVNVTGIYRAV 396

  Fly   242 P---GKRGGYTSGTFRTVL--------LANNISLLSKESNLDI-SREDIMLCKKLAKNNDIFELL 294
            |   ..|.......::|.:        .|..:..|.:|:...: |.:.:.|.|:|::..||:|.|
Mouse   397 PIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVKLLKELSRKPDIYERL 461

  Fly   295 SKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTR--LRGDINVLLIGDPSVAKSQLLRYVLNTA 357
            :.:|||||:.|..:|:.||..|.||..|...:..|  .|.:||:||.|||..:|||||:||.|..
Mouse   462 ASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLV 526

  Fly   358 PRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVME 422
            ||...|:|:|||.|||||.|..|.||.:..|:.||:||:|.|:.||||||||::..|:.:|||||
Mouse   527 PRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVME 591

  Fly   423 QGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSD 487
            |..::|:||||...||||.||||||||:..:::..||.:|||.|..:|||||||:|:|||..|..
Mouse   592 QQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEA 656

  Fly   488 VDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQR 552
            .|:.::.|:|.:: |::.::.:                    ||..|..|.:.|.|..|
Mouse   657 YDRRLAHHLVSLY-YQSEEQVE--------------------EEFLDMAVLKDYIAYAH------ 694

  Fly   553 HEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITA---RTLET 614
                             ..:.|:|.|:|.:|:...|..:|.       :..::.:.:   |.||:
Mouse   695 -----------------STIMPRLSEEASQALIEAYVNMRK-------IGSSRGMVSAYPRQLES 735

  Fly   615 LIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRRNSGSDAEDDNGEASSQR 679
            ||||:.|||:.|.|..|...|...|..|.:.|.              :.|.:|
Mouse   736 LIRLAEAHAKVRFSNKVEAIDVEEAKRLHREAL--------------KQSATD------------ 774

  Fly   680 SPSRRSKRTRTATVGADSDEEDIEPPQPDAGDLTRRETRRSLPARSVAMLMASPSSEEQSVATST 744
                    .||..|              |...||..              |::.|.:.:......
Mouse   775 --------PRTGIV--------------DISILTTG--------------MSATSRKRKEELAEA 803

  Fly   745 TEPAIISDARLGEFKNNLQRLFREAREQSLALARITTAINVGSQEPFTAGEIEAAVHRMTEDNQI 809
            ....|:|..:....|  .|:||.:.|.||      .|||        |....|.|:..:.:|:.:
Mouse   804 LRKLILSKGKTPALK--YQQLFEDIRGQS------DTAI--------TKDMFEEALRALADDDFL 852

  Fly   810 MVADDIVFLI 819
            .|....|.|:
Mouse   853 TVTGKTVRLL 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	23/107 (21%)
		MCM	106..648	CDD:214631	189/562 (34%)
Mcm4	NP_032591.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..121
		MCM_N	162..263	CDD:464206	24/101 (24%)
		MCM	266..769	CDD:214631	189/591 (32%)
		Arginine finger	641..644		2/2 (100%)