DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and Mcm2

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_032590.2	Gene:	Mcm2 / 17216	MGIID:	105380	Length:	904	Species:	Mus musculus

Alignment Length:	751	Identity:	245/751 - (32%)
Similarity:	370/751 - (49%)	Gaps:	103/751 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DIQREYVDFLD---DEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLSNAADEQLA 72
            :|...:.:||.   |.....::...:.||..|..:.|:||..||..:....|..|....|:....
Mouse   194 EIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 258

  Fly    73 FGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTP-----RSLTSIYLGNMVCVEGIVTKVS 132
            |..|..|....:.|.|.::...:.|...      |: |     |||..::|..::...|:||..:
Mouse   259 FDEAALEVVLAMYPKYDRITNHIHVRIS------HL-PLVEELRSLRQLHLNQLIRTSGVVTSCT 316

  Fly   133 LIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVPSGAAYPTKDEDG----NLLETEYGLSVYKDH 193
            .:.|::....:.|.....|: ..:....:.|..|...  |.....|    |:.||     :|:::
Mouse   317 GVLPQLSMVKYNCSKCNFVL-GPFCQSQNQEVKPGSC--PECQSAGPFEINMEET-----IYQNY 373

  Fly   194 QTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLPGKRGGYTSG------- 251
            |.:.|||.|.|..||:||||.|.:...||||.|||||.:::.|.|      ...|...
Mouse   374 QRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIY------HNNYDGSLNTANGF 432

  Fly   252 -TFRTVLLANNISLLSKESNL---DISREDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAI 312
             .|.|::|||:::  .|::.:   :::.||:.:...|:|:..|.|.:..|:||||:||..:|:.:
Mouse   433 PVFATIILANHVA--KKDNKVAVGELTDEDVKMITGLSKDQQIGEKIFASIAPSIYGHEDIKRGL 495

  Fly   313 LCLLLGGVEKILPNGT-RLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAA 376
            ...|.||..| .|.|. ::||||||||.|||..||||.|:|:...:.|||.|||:|:|.|||||.
Mouse   496 ALALFGGEPK-NPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAY 559

  Fly   377 VTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARC 441
            |.....:.|..|||||:|||||||..|||||||:|.|||:|||.|||..::||||||..||.|||
Mouse   560 VQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARC 624

  Fly   442 SVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPK 506
            :|:|||||:.||||...|..||:.|.:.::||||:|.|:.|.:|...|:|::..||..|...:|.
Mouse   625 TVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHVRHHPS 689

  Fly   507 EADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAK- 570
            ....|.|:.|.:...::......|.                         |..|.::|||..||
Mouse   690 NKKDEGLTNGGTLEPAMPNTYGVEP-------------------------LPQEVLKKYIIYAKE 729

  Fly   571 CMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDD 635
            .::|||.:...:.:|..||.||.:......:    |||.|.:|::||::.||||..:...|..||
Mouse   730 RVRPKLNQMDQDKVARMYSDLRKESMATGSI----PITVRHIESMIRMAEAHARMHLRDYVMEDD 790

  Fly   636 AHAAIELVQFAYFKKVLDKDRPSKRRRNSGSDA------EDDNG-------EASSQRSPSRRSKR 687
            .:.||.::..::    :|..:.|..|....:.|      .|:|.       :..:::...:|::
Mouse   791 VNMAIRVMMESF----IDTQKFSVMRSMRKTFARYLSFRRDNNDLLLFILKQLVAEQVTYQRNR- 850

  Fly   688 TRTATVGADSDEEDIEPPQPDAGDLTRRETRRSLPA 723
                 .||..|  .||.|:.|..|..|:....:|.|
Mouse   851 -----FGAQQD--TIEIPEKDLMDKARQINIHNLSA 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	20/85 (24%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	206/563 (37%)
Mcm2	NP_032590.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..166
		Interaction with KAT7. /evidence=ECO:0000269\|PubMed:11278932	2..257		15/62 (24%)
		MCM2_N	72..182	CDD:289392
		MCM_N	198..310	CDD:291233	26/118 (22%)
		MCM	291..803	CDD:214631	204/561 (36%)
		P-loop_NTPase	485..>632	CDD:304359	86/147 (59%)
		Arginine finger	655..658		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820