Protein Alignment Mcm3 and Mcm2

DIOPT Version :10

• Sequence 1: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_032590.2
• Gene: Mcm2 / 17216
• MGIID: 105380
• Length: 904
• Species: Mus musculus
• Alignment Length: 751
• Identity: 245/751 - (32%)
• Similarity: 370/751 - (49%)
• Gaps: 103/751 - (13%)

  Fly    11 DIQREYVDFLD---DEEDQGIYAGHVKDMIAEKSKRLIVNVNDLKRKNPQRALGLLSNAADEQLA 72
            :|...:.:||.   |.....::...:.||..|..:.|:||..||..:....|..|....|:....
Mouse   194 EIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQI 258

  Fly    73 FGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTP-----RSLTSIYLGNMVCVEGIVTKVS 132
            |..|..|....:.|.|.::...:.|...      |: |     |||..::|..::...|:||..:
Mouse   259 FDEAALEVVLAMYPKYDRITNHIHVRIS------HL-PLVEELRSLRQLHLNQLIRTSGVVTSCT 316

  Fly   133 LIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVPSGAAYPTKDEDG----NLLETEYGLSVYKDH 193
            .:.|::....:.|.....|: ..:....:.|..|...  |.....|    |:.||     :|:::
Mouse   317 GVLPQLSMVKYNCSKCNFVL-GPFCQSQNQEVKPGSC--PECQSAGPFEINMEET-----IYQNY 373

  Fly   194 QTLTIQEMPEKAPAGQLPRSVDIVCDDDLVDRCKPGDRVQIVGSYRCLPGKRGGYTSG------- 251
            |.:.|||.|.|..||:||||.|.:...||||.|||||.:::.|.|      ...|...
Mouse   374 QRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIY------HNNYDGSLNTANGF 432

  Fly   252 -TFRTVLLANNISLLSKESNL---DISREDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAI 312
             .|.|::|||:::  .|::.:   :::.||:.:...|:|:..|.|.:..|:||||:||..:|:.:
Mouse   433 PVFATIILANHVA--KKDNKVAVGELTDEDVKMITGLSKDQQIGEKIFASIAPSIYGHEDIKRGL 495

  Fly   313 LCLLLGGVEKILPNGT-RLRGDINVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAA 376
            ...|.||..| .|.|. ::||||||||.|||..||||.|:|:...:.|||.|||:|:|.|||||.
Mouse   496 ALALFGGEPK-NPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAY 559

  Fly   377 VTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARC 441
            |.....:.|..|||||:|||||||..|||||||:|.|||:|||.|||..::||||||..||.|||
Mouse   560 VQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARC 624

  Fly   442 SVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPK 506
            :|:|||||:.||||...|..||:.|.:.::||||:|.|:.|.:|...|:|::..||..|...:|.
Mouse   625 TVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHVRHHPS 689

  Fly   507 EADGEPLSMGSSYADSLSFVSSSEEKKDTEVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAK- 570
            ....|.|:.|.:...::......|.                         |..|.::|||..||
Mouse   690 NKKDEGLTNGGTLEPAMPNTYGVEP-------------------------LPQEVLKKYIIYAKE 729

  Fly   571 CMKPKLGEQACEAIANEYSRLRSQEAVETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDD 635
            .::|||.:...:.:|..||.||.:......:    |||.|.:|::||::.||||..:...|..||
Mouse   730 RVRPKLNQMDQDKVARMYSDLRKESMATGSI----PITVRHIESMIRMAEAHARMHLRDYVMEDD 790

  Fly   636 AHAAIELVQFAYFKKVLDKDRPSKRRRNSGSDA------EDDNG-------EASSQRSPSRRSKR 687
            .:.||.::..::    :|..:.|..|....:.|      .|:|.       :..:::...:|::
Mouse   791 VNMAIRVMMESF----IDTQKFSVMRSMRKTFARYLSFRRDNNDLLLFILKQLVAEQVTYQRNR- 850

  Fly   688 TRTATVGADSDEEDIEPPQPDAGDLTRRETRRSLPA 723
                 .||..|  .||.|:.|..|..|:....:|.|
Mouse   851 -----FGAQQD--TIEIPEKDLMDKARQINIHNLSA 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	20/90 (22%)
		MCM	106..648	CDD:214631	206/563 (37%)
Mcm2	NP_032590.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..166
		Interaction with KAT7. /evidence=ECO:0000269|PubMed:11278932	2..257		15/62 (24%)
		Interaction with DNJC9. /evidence=ECO:0000250|UniProtKB:P49736	61..130
		MCM2_N	72..182	CDD:403724
		MCM_N	197..287	CDD:464206	20/95 (21%)
		MCM	291..803	CDD:214631	204/561 (36%)
		Arginine finger	655..658		2/2 (100%)