DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcm3 and mcm8

DIOPT Version :9

Sequence 1:	NP_511048.2	Gene:	Mcm3 / 31449	FlyBaseID:	FBgn0284442	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_002665161.2	Gene:	mcm8 / 100333576	ZFINID:	ZDB-GENE-120927-1	Length:	852	Species:	Danio rerio

Alignment Length:	755	Identity:	226/755 - (29%)
Similarity:	364/755 - (48%)	Gaps:	139/755 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EGEQFIKDIQ--REY----VDFLD-DE-EDQGIYAGHVKDMIAEK--SKRLIVNVNDLKRKNPQR 58
            |...:::.|:  .:|    :|..| || |.:|......||:::.|  |..|.....||| :.|::
Zfish   100 ESSPYVEKIKVFEQYFTSQIDLYDKDEIERKGSILVDYKDLLSNKQVSHSLPDLARDLK-EMPEK 163

  Fly    59 ALGLLSNAADEQLAFGRALKEYASTVDPGYAKMHEDLFVGFEGCFGNRHVTPR-----------S 112
            .|..|..|..:.|...  |:.:|:.:     :..|:|..|........|::.|           |
Zfish   164 ILDCLGVAIHQVLTLD--LERHAAEL-----QGQEELPAGIRPIINIPHISARLYNYEPLTPLKS 221

  Fly   113 LTSIYLGNMVCVEGIVTKVSLIRP---KVVRSVHYCPNTRKVM--ERKYTDLTSFEAVPSGAAYP 172
            |.:...|..|.:.|.|.:||.|:|   |:....:.|.:|:.|.  :.|||             .|
Zfish   222 LRANLYGKFVVIRGTVVRVSNIKPLCMKLAFVCNSCGDTQSVTLPDGKYT-------------MP 273

  Fly   173 TKDEDGNLLETE-------------YGLSVYKDHQTLTIQEM--PEKAPAGQLPRSVDIVCDDDL 222
            ||     .|::|             :.|:|  |.||:.:||:  .::..:|::||:::.....||
Zfish   274 TK-----CLQSECRGRSFTPNRSSPFTLTV--DWQTIKVQELMSGDQRESGRIPRTIECELTQDL 331

  Fly   223 VDRCKPGDRVQIVGSYRCLPGKRGGYTSG-----TFRTVLLANNIS--------LLSKES----N 270
            ||.|.|||.|.|.|..:.  ....|.|..     .|...:.||::|        .:|:..    :
Zfish   332 VDSCVPGDMVTITGVIKV--SNEEGSTRNKKDKCMFLLYIQANSVSNSKGQKSKAVSESEGQGPS 394

  Fly   271 LDISREDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTR--LRGD 333
            ::.|.:|:...:::....|:|:|:..||.|.|:||..||..:...|.||.:|.:.:..|  :|||
Zfish   395 VEFSIKDLYAIQEIQAQEDLFKLIVNSLCPVIYGHLLVKAGLALALFGGCQKYVDDKNRIPIRGD 459

  Fly   334 INVLLIGDPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADR 398
            .::|::|||.:.|||:|:.|.|.|||.:...|..::..|||.:::.|..:|:..|||||:||.|:
Zfish   460 PHMLIVGDPGLGKSQMLQAVCNVAPRGVYVCGNTTTTSGLTVSLSRDSGSGDYALEAGALVLGDQ 524

  Fly   399 GVVCIDEFDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMEN 463
            |:.||||||||.. ...|:.|.|||..::::||||..:|.||.|::||||||.|.|::.||..||
Zfish   525 GICCIDEFDKMGS-QHQALLEAMEQQSISLAKAGIVCTLPARTSIIAAANPVGGHYNKGKTVSEN 588

  Fly   464 IGLQDSLLSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSS 528
            :.:..:|||||||:|::||..:.|.|.::|:||:.| |........|...:..:::..|:|.:..
Zfish   589 LKMGSALLSRFDLVFILLDTPNEDHDHLLSEHVMAM-RAGKSGAVSGAAATRFNTHESSISILEV 652

  Fly   529 SEEKKDTEVY-----EKYDALLHGKSRQRHEKILSVEFMRKYIHIAK-CMKPKLGEQACEAIANE 587
            |.||...:..     |.:|.:.|             :.:|||:..|: .:.|.|..:|.:.:.:.
Zfish   653 SSEKPLADTLKLVPGEAFDPIPH-------------QLLRKYVGYARHYVHPTLSAEAAQVLQDF 704

  Fly   588 YSRLRSQEAVETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVL 652
            |..||.|    ...|.:.|||.|.||:||||:.|.||..:.:..|..||...:|::
Zfish   705 YLELRKQ----NQTADSTPITTRQLESLIRLTEARARVELREKATQSDAEDVVEIM--------- 756

  Fly   653 DKDRPSKRRRNSGSDA-EDDNGEASSQRSP-----SRRSK 686
                     ::|.:|. .|:.|.....||.     |.|||
Zfish   757 ---------KHSLTDTYSDEFGRLDFDRSQLGSGMSNRSK 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm3	NP_511048.2	MCM_N	18..101	CDD:379644	24/86 (28%)
Mcm3	NP_511048.2	MCM	106..648	CDD:214631	189/597 (32%)
mcm8	XP_002665161.2	Mcm2	110..801	CDD:224162	224/745 (30%)
		MCM_N	111..235	CDD:291233	31/131 (24%)
		AAA	451..605	CDD:99707	73/154 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232729at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820