DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rnp4F and sart3

DIOPT Version :9

Sequence 1:	NP_001096883.3	Gene:	Rnp4F / 31448	FlyBaseID:	FBgn0014024	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001025289.1	Gene:	sart3 / 558581	ZFINID:	ZDB-GENE-040724-10	Length:	951	Species:	Danio rerio

Alignment Length:	984	Identity:	197/984 - (20%)
Similarity:	357/984 - (36%)	Gaps:	291/984 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 PSVEETEGGNAAGRGRARNDSSSSSDDVGVIEGSELESNSEVSSDSDSDSDNAGGGNQLERSYQE 156
            |.:||    .|.|..|.........:.:|| |.||.|...:.|.|   :.:|.....:||... .
Zfish    13 PDIEE----EAEGMEREMESEDDEEEGMGV-EHSEEEDEEDTSED---ERENEAEIQRLEEQL-S 68

  Fly   157 LNALPSKKFAQMVSLIGIAFKLNDLEKIESSVLELQNLATVPAHVWLKYLKARLVVTQTDEERKA 221
            :||........::.|:....||:.|.|....:.||..|.   ..:||.:||..:.:|:.:.:|:.
Zfish    69 INAFDYNCHVDLIKLLRQEGKLHRLRKARQKMSELFPLT---EEIWLDWLKDEIRITEDESDREK 130

  Fly   222 FEEQCAKALGYYYS----IPLSEYVVNYLVDQGNVQN--------------HV-----LWAKLLA 263
            ..|...:|:..|..    :...:|.:..:..||.::.              |:     :| :...
Zfish   131 VYELFERAIKDYVCPEIWLEYVQYSIGGMGAQGGIERVRSIFERALTAVGLHMTKGASIW-EAYR 194

  Fly   264 DYDVERPDFGDKLRSLISTI--------TDENEAAAFVEMLQKHCVTWTCNVEQRQMI------- 313
            ::::          .::||:        :.|.:.....::.:.|      .:.:||:.
Zfish   195 EFEI----------VILSTVQPPPGTVPSQEQQELLSAQLERIH------TLFRRQLAVPLMDME 243

  Fly   314 ---------------KSVVDKFKQHLDETTRGWDW------SEQHKAHVYDVETLSLDDDLKN-- 355
                           ::|..::::.|.:..:|..:      ||..|...|.   ..:|.::|.
Zfish   244 GTYAEYSDWADDGVPETVTHQYRRALQQMEKGKPYEEALLVSEPPKLAEYQ---SYIDFEIKEGD 305

  Fly   356 -AVIRFIFERSVAKFPIVDVLWLSYIEFIQFEGVTVPENEDENEVTAEMVAKRAKRLGKGFLRNT 419
             |.::.||||::|:..:|..||:.|..::.                     ::.|      :::.
Zfish   306 PARVQIIFERALAENCLVPDLWIKYTTYLD---------------------RQLK------IKDL 343

  Fly   420 ELDLANRGVRSHP-SVQLNHRFLDLMERSDFELAEVDEEIRLILQR---IVTDMDMTVELHLDYL 480
            .|....|.||:.| ::.|...:|..:||...:...|.:.....|..   ..||.....:.:||||
Zfish   344 VLSAHERAVRNCPWTMGLWKSYLLALERHGADHQTVKDVFEKALNAGFIQATDYVEIWQSYLDYL 408

  Fly   481 AYRIRNTNASDEQQVASLRAAFNHAWE----ELTVLYGDQADTRYEVLQLWAQVEYTQLGSPDNG 541
            ..|: :.:.....::..|||||:.:.|    ::...:.:..|....::|:||::|.....:....
Zfish   409 RRRV-DFSKGKSMELDELRAAFSRSLEYLKQDVEERFSESGDLSCTLMQIWARIEALHCKNMQKA 472

  Fly   542 REIWRQIMGYPGSSIRGLLWLNFAQMESEYNGGHGTRDVLRKALSQPVLENGLMVQEFFRRYERC 606
            ||:|..|| ..|::....:||.:..:|..|......|..|.:|: |...:....|.:....:||.
Zfish   473 RELWDSIM-TKGNAKYANMWLEYYNLERSYGDAAHCRKALHRAV-QCTSDYPEHVCDVLLNFERV 535

  Fly   607 YGTYES-IAACQALDLPVEYV-KPRSRIKPNSQSAYPRQQKLKPRQQQQ-------QTNREPLNR 662
            .|:.|. .||.|..:..:..| :.|:|: ...::.:.||::.|..|:::       |...:..||
Zfish   536 EGSLEDWDAAVQKTETKLNRVCEQRARV-AEKEALHARQEEEKAEQRRKVKADKKAQKKGQKANR 599

  Fly   663 EQRRRQAHEQQQQQQQQQ-------------------------------KHGIKKSRTEPSG--- 693
            ...:|:|.:..:::..::                               :......:|||.|
Zfish   600 TGDKRKAEDDDEEEWGEEAELPSKRLRGEDDFDSTVTEELMETESGLFGRRAPPARKTEPPGFRK 664

  Fly   694 ---GATSPPSKVKGPANAEAKESN----------------------------------------- 714
               ||..|..:.......:.|:.|
Zfish   665 NQQGAPEPQRQPHDMPKEQRKDENCVFVSNLTFNMEDPEGKLRTLFQGCGTIQQVRPVFTAKGTF 729

  Fly   715 ----------------------------------------------FKYSPNMEINKIFVRNLHP 733
                                                          |||..:||.:|||:..|..
Zfish   730 RGYCYVQFEDRLAVPEALKMDRQEVDGRPMYVSPCVDKNKNPDFKVFKYKTSMEKHKIFISGLPY 794

  Fly   734 ACSKEELHELFSPFGTIKDVRLVHKLNKQFKGIAYVEFEKPGEAQRAVAGRDGCLFKGMNISVAI 798
            :.:||.|.:|....|||:.:|:|...:.:.||:||||||...:|.:||...||.:.:...:||||
Zfish   795 SATKETLEDLCKEHGTIRAIRIVTNRSGKSKGLAYVEFEDEAQASQAVLKMDGTMLENFTLSVAI 859

  Fly   799 SNPPPRGTSAVKPSVAPKR-----------------RVPTSLIPTTLVRQEVAAKKLRLLLPEPG 846
            ||||.|   .:|...||.|                 |...||:|.:|.||.....|     .|.|
Zfish   860 SNPPGR---RMKDEAAPSRFLGAAMPRQLQGARGKGRTQISLLPRSLYRQSTPDAK-----AENG 916

  Fly   847 DISSTSASV 855
            .||:..|:|
Zfish   917 TISAPHATV 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnp4F	NP_001096883.3	RRM	<681..>811	CDD:223796	49/222 (22%)
		RRM_SF	722..802	CDD:302621	33/79 (42%)
		Paf1	<816..922	CDD:281915	15/57 (26%)
		Lsm_interact	922..940	CDD:283133
sart3	NP_001025289.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		15/52 (29%)
		RNA14	62..>496	CDD:227438	89/486 (18%)
		HAT 1. /evidence=ECO:0000255	88..120		11/34 (32%)
		HAT 2. /evidence=ECO:0000255	126..157		5/30 (17%)
		HAT 3. /evidence=ECO:0000255	163..199		3/46 (7%)
		HAT 4. /evidence=ECO:0000255	222..255		3/38 (8%)
		HAT	304..336	CDD:214642	10/52 (19%)
		HAT 5. /evidence=ECO:0000255	304..336		10/52 (19%)
		HAT 6. /evidence=ECO:0000255	339..371		8/37 (22%)
		HAT 7. /evidence=ECO:0000255	374..410		8/35 (23%)
		HAT 8. /evidence=ECO:0000255	467..500		9/33 (27%)
		Necessary and sufficient for U6 snRNA binding. /evidence=ECO:0000250\|UniProtKB:Q15020	517..941		87/418 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..686		16/118 (14%)
		RRM1_SART3	689..762	CDD:240837	0/72 (0%)
		RRM	<774..919	CDD:223796	54/152 (36%)
		RRM2_SART3	783..863	CDD:240838	33/79 (42%)
		LSM_int_assoc	861..920	CDD:293211	19/66 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	905..938		9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596550
Domainoid	1	1.000	51	1.000	Domainoid score	I11572
eggNOG	1	0.900	-	-		E1_KOG0128
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4636
OMA	1	1.010	-	-		QHG54905
OrthoDB	1	1.010	-	-		D159985at33208
OrthoFinder	1	1.000	-	-		FOG0004071
OrthoInspector	1	1.000	-	-		oto39616
orthoMCL	1	0.900	-	-		OOG6_103012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3656
SonicParanoid	1	1.000	-	-		X5096
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.700