DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnp4F and RBM23

DIOPT Version :9

Sequence 1:	NP_001096883.3	Gene:	Rnp4F / 31448	FlyBaseID:	FBgn0014024	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_024305408.1	Gene:	RBM23 / 55147	HGNCID:	20155	Length:	515	Species:	Homo sapiens

Alignment Length:	203	Identity:	49/203 - (24%)
Similarity:	83/203 - (40%)	Gaps:	39/203 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   627 KPRSRIKP-----NSQSAYP-RQQKLKPRQQQQQTNREPLNREQRRR-QAHEQQQQQQQQQKHGI 684
            :.|||.:.     ||:|..| ||.:.:.|...::...|..:|:.||. :.|.:........::|.
Human   119 RSRSRDRDRYRRRNSRSRSPGRQCRHRSRSWDRRHGSESRSRDHRREDRVHYRSPPLATGYRYGH 183

  Fly   685 KKSRTEPSGGATSPPSKVKGPANAEAKESNFKYSP-NMEINKIFVRNLHPACSKEELHELFSPFG 748
            .|          ||..:.|.|    .:|.....|| ..:...:|...|.......:|.:.||..|
Human   184 SK----------SPHFREKSP----VREPVDNLSPEERDARTVFCMQLAARIRPRDLEDFFSAVG 234

  Fly   749 TIKDVRLVHKLN-KQFKGIAYVEFEKPGEAQRAVAGRDGCLFKGMNISVAISNPPPRGTS-AVKP 811
            .::|||::...| ::.||||||||               |..:.:.:::.::.....|.. .|:.
Human   235 KVRDVRIISDRNSRRSKGIAYVEF---------------CEIQSVPLAIGLTGQRLLGVPIIVQA 284

  Fly   812 SVAPKRRV 819
            |.|.|.|:
Human   285 SQAEKNRL 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnp4F	NP_001096883.3	RRM	<681..>811	CDD:223796	30/132 (23%)
		RRM_SF	722..802	CDD:302621	19/80 (24%)
		Paf1	<816..922	CDD:281915	2/4 (50%)
		Lsm_interact	922..940	CDD:283133
RBM23	XP_024305408.1	RRM	143..514	CDD:330708	40/179 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3656
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030