DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnp4F and Sart3

DIOPT Version :9

Sequence 1:	NP_001096883.3	Gene:	Rnp4F / 31448	FlyBaseID:	FBgn0014024	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_006249563.1	Gene:	Sart3 / 304582	RGDID:	1311646	Length:	978	Species:	Rattus norvegicus

Alignment Length:	1017	Identity:	219/1017 - (21%)
Similarity:	379/1017 - (37%)	Gaps:	308/1017 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 SSDDEPSVE-----ETEG----GNAAGRGRARNDSSSSSDDVGVIEGSELESNSEVSSDSDSDSD 142
            ||..||.||     |.||    ...||.||    ...||.:....:|.|.|.:.|..|:||.|.:
  Rat     7 SSASEPEVEPQARPEAEGEEDEAKPAGVGR----KVLSSAETAKAKGPEREVHQEGVSESDGDEE 67

  Fly   143 NAGGGNQLERS----------YQELNALPSKKFAQMVSLIGIAFKLN-----------DLEKIES 186
            :|...:..|.|          .:|.|.|..::..:.:|:.|..:..:           :|.|:..
  Rat    68 DAAMASSAESSAGEDEWEYDEEEEKNQLEIERLEEQLSINGYDYNCHVGLIRLLRLEGELNKVRM 132

  Fly   187 SVLELQNLATVPAHVWLKYL--KARLVVTQTDEER--KAFEEQCAKALGYYYSIPLSEYVVNYLV 247
            :..::..:..:...:||::|  :..:.|...|.||  :.||......:.....:...:|.|..:.
  Rat   133 ARQKMSEIFPLTEELWLEWLHDEISMAVDGLDRERVYELFERAVKDYICPNIWLEYGQYSVGGIG 197

  Fly   248 DQGNVQN--------------HVLWAKLLADYDVERPDFGDKL----RSLISTITDENEAAAFVE 294
            .:|.::.              |:  .|.||.::..| :|...:    |.:.:.::..:....|..
  Rat   198 QKGGLEKVRSVFERALSSVGLHM--TKGLAIWEAYR-EFESAIVEAARPIAAFLSPSDREQTFDS 259

  Fly   295 MLQK-HCV--------------------TWTCNVEQRQMIKSVVDKFKQHLDETTRGWDWSE--- 335
            .|:: |.:                    .|:    :..:.:||:..:::.|.:..:...:.|
  Rat   260 QLERVHSLFRRQLAIPLYEMEATFAEYEEWS----EEPIPESVLQSYQKALGQLEKYKPYEEALL 320

  Fly   336 --------QHKAHVYDVETLSLDDDLKNAVIRFIFERSVAKFPIVDVLWLSYIEFIQFEGVTVPE 392
                    :::|:: |.| :.:.|.   |.|:.||||::.:..:|..||:.|.:::.
  Rat   321 QAEAPRLAEYQAYI-DFE-MKVGDP---ARIQLIFERALVENCLVPDLWIRYSQYLD-------- 372

  Fly   393 NEDENEVTAEMVAKRAKRLGKGFLRNTELDLANRGVRSHP-SVQLNHRFLDLMERS--DFELAEV 454
                         ::.|      :::..|.:.:|.||:.| :|.|..|:|..|||.  |.::...
  Rat   373 -------------RQLK------VKDLVLSVHSRAVRNCPWTVALWSRYLLAMERHGLDHQMISA 418

  Fly   455 DEEIRLILQRI-VTDMDMTVELHLDYLAYRIRNTNASDEQQVASLRAAFNHAWE----ELTVLYG 514
            ..|..|....| .||.....:::||||..|: :......:::..||:.|..|.|    |:...:.
  Rat   419 TFENALSAGFIQATDYVEIWQVYLDYLRRRV-DFRQDSSKELEELRSMFTRALEYLQQEVEERFS 482

  Fly   515 DQADTRYEVLQLWAQVEYTQLGSPDNGREIWRQIMGYPGSSIRGLLWLNFAQMESEYNGGHGTRD 579
            :..|....::|.||:||.....:....||:|..|| ..|::....:||.:..:|.    .||...
  Rat   483 ESGDPSCLIMQSWARVEARLCNNMQKARELWDSIM-TRGNAKYANMWLEYYNLER----AHGDTQ 542

  Fly   580 VLRKALSQPVL------ENGLMVQEFFRRYERCYGTYESIAACQALDLPVEYVKPR-SRIKPNSQ 637
            ..||||.:.|.      |:   |.|.....||..||.|.      .||.::..:.| :|:.....
  Rat   543 HCRKALHRAVQCTSDYPEH---VCEVLLTMERTEGTLED------WDLAIQKTETRLARVNEQRM 598

  Fly   638 SAYPRQQKLKPRQQQQQTNREPLNREQR--------------------RRQAHEQQQQQQQQQKH 682
            .|..::..|..:::::...|:.:..|::                    .|:..|::::|..:::.
  Rat   599 KAAEKEAALVQQEEEKAEQRKKVRAEKKALKKKKTRGADKRKAGEDDDERECGEEEEEQPSKRRR 663

  Fly   683 -------GI---KKSRTEPSGGA----TSPPSKVK------------------------------ 703
                   |:   |:..|:.||..    .:||||.|
  Rat   664 MENSLASGVASAKEEETKLSGKCLTIDVAPPSKQKEKAASLKRDMPKVAHDSSKDSVTVFVSNLP 728

  Fly   704 ----------------------------------GPANAEAKESN-------------------- 714
                                              |....|.||..
  Rat   729 YSIEEPEVKLRPLFEACGEVVQIRPIFSNRGDFRGYCYVEFKEEKSAQQALDLDRKNVEGRPMFV 793

  Fly   715 --------------FKYSPNMEINKIFVRNLHPACSKEELHELFSPFGTIKDVRLVHKLNKQFKG 765
                          |:||..:|.:|:|:..|..:|:||||..:....||:||:|||.....:.||
  Rat   794 SPCVDKSKNPDFKMFRYSTTLEKHKLFISGLPFSCTKEELEGICKAHGTVKDLRLVTNRAGKPKG 858

  Fly   766 IAYVEFEKPGEAQRAVAGRDGCLFKGMNISVAISNPPPRGTSAVKPSV-----AP---------- 815
            :||||:|...:|.:||...||...|...|.|||||||.|.... ||.|     ||
  Rat   859 LAYVEYENESQASQAVLKMDGMTIKENVIKVAISNPPQRKVPE-KPEVRTAPGAPMVPRQMYGAR 922

  Fly   816 -KRRVPTSLIPTTLVRQEVAAKKLRLLLPEPGDISSTSASVD 856
             |.|...||:|..|.||..|.:...  .|.||..::||.:.:
  Rat   923 GKGRTQLSLLPRALQRQGAAPQAEN--GPAPGLAATTSVATE 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnp4F	NP_001096883.3	RRM	<681..>811	CDD:223796	55/241 (23%)
		RRM_SF	722..802	CDD:302621	35/79 (44%)
		Paf1	<816..922	CDD:281915	14/41 (34%)
		Lsm_interact	922..940	CDD:283133
Sart3	XP_006249563.1	RNA14	99..>477	CDD:227438	74/417 (18%)
		NRDE-2	350..>503	CDD:285605	43/180 (24%)
		RRM1_SART3	721..794	CDD:240837	4/72 (6%)
		RRM2_SART3	815..895	CDD:240838	35/79 (44%)
		LSM_int_assoc	893..951	CDD:293211	19/60 (32%)
		Lsm_interact	960..977	CDD:283133	0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354270
Domainoid	1	1.000	82	1.000	Domainoid score	I8232
eggNOG	1	0.900	-	-		E1_KOG0128
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I4914
OMA	1	1.010	-	-		QHG54905
OrthoDB	1	1.010	-	-		D159985at33208
OrthoFinder	1	1.000	-	-		FOG0004071
OrthoInspector	1	1.000	-	-		oto96288
orthoMCL	1	0.900	-	-		OOG6_103012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5096
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.670