DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rnp4F and RNPS1

DIOPT Version :9

Sequence 1:NP_001096883.3 Gene:Rnp4F / 31448 FlyBaseID:FBgn0014024 Length:941 Species:Drosophila melanogaster
Sequence 2:NP_001273554.1 Gene:RNPS1 / 10921 HGNCID:10080 Length:305 Species:Homo sapiens


Alignment Length:261 Identity:58/261 - (22%)
Similarity:98/261 - (37%) Gaps:74/261 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   626 VKPRS--RIKPNSQSAYPR-----------QQKLKPRQQQQQTNREPLNREQRRRQAHEQQQQQQ 677
            ||.:|  .:|.|::.:..|           .:|.|.|.:.:...:|...:::.|.:..:::....
Human     6 VKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASS 70

  Fly   678 QQQKHGIKKSRTEPSGGATS--------------------------------------------- 697
            .......:.|.|..||.:||                                             
Human    71 GSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRR 135

  Fly   698 -PPSKVKGPANAEAKESNFKYSPNMEINKIFVRNLHPACSKEELHELFSPFGTIKDVRL-VHKLN 760
             ..||.|.|...|.:..  :.||:.:..|:.:..|....:|:.:.|:||.:|.||.:.: |.:::
Human   136 RSRSKSKPPKRDEKERK--RRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMH 198

  Fly   761 KQF-KGIAYVEFEKPGEAQRAVAGRDGCLFKGMNISVAI-----SNPPPRGTSAVKPSVAPKRRV 819
            ... ||.||||||.|.||::|:...||....|..|:...     ..||||..|      .|:|.:
Human   199 PHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPPPRRFS------PPRRML 257

  Fly   820 P 820
            |
Human   258 P 258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rnp4FNP_001096883.3 RRM <681..>811 CDD:223796 44/182 (24%)
RRM_SF 722..802 CDD:302621 26/86 (30%)
Paf1 <816..922 CDD:281915 2/5 (40%)
Lsm_interact 922..940 CDD:283133
RNPS1NP_001273554.1 Necessary for interaction with the cleaved p110 isoform of CDC2L1 1..220 45/215 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..170 26/165 (16%)
Necessary for interaction with SRP54, nuclear localization and exon-skipping. /evidence=ECO:0000269|PubMed:14729963 1..161 24/156 (15%)
Necessary for interactions with UPF2 and UPF3B and UPF2-dependent NMD 69..121 6/51 (12%)
Necessary for interaction with PNN and exon-skipping 156..242 27/85 (32%)
Interaction with SAP18 and ACIN1. /evidence=ECO:0000269|PubMed:20966198 159..244 26/84 (31%)
RRM_RNPS1 163..236 CDD:409800 25/72 (35%)
Necessary for interaction with TRA2B, nuclear localization and exon-skipping. /evidence=ECO:0000269|PubMed:14729963 238..305 8/27 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..305 8/25 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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