Protein Alignment Rnp4F and RNPS1

DIOPT Version :10

• Sequence 1: NP_511047.2
• Gene: Rnp4F / 31448
• FlyBaseID: FBgn0014024
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: NP_006702.1
• Gene: RNPS1 / 10921
• HGNCID: 10080
• Length: 305
• Species: Homo sapiens
• Alignment Length: 261
• Identity: 58/261 - (22%)
• Similarity: 98/261 - (37%)
• Gaps: 74/261 - (28%)

  Fly   626 VKPRS--RIKPNSQSAYPR-----------QQKLKPRQQQQQTNREPLNREQRRRQAHEQQQQQQ 677
            ||.:|  .:|.|::.:..|           .:|.|.|.:.:...:|...:::.|.:..:::....
Human     6 VKKKSLLGVKENNKKSSTRAPSPTKRKDRSDEKSKDRSKDKGATKESSEKDRGRDKTRKRRSASS 70

  Fly   678 QQQKHGIKKSRTEPSGGATS--------------------------------------------- 697
            .......:.|.|..||.:||
Human    71 GSSSTRSRSSSTSSSGSSTSTGSSSGSSSSSASSRSGSSSTSRSSSSSSSSGSPSPSRRRHDNRR 135

  Fly   698 -PPSKVKGPANAEAKESNFKYSPNMEINKIFVRNLHPACSKEELHELFSPFGTIKDVRL-VHKLN 760
             ..||.|.|...|.:..  :.||:.:..|:.:..|....:|:.:.|:||.:|.||.:.: |.:::
Human   136 RSRSKSKPPKRDEKERK--RRSPSPKPTKVHIGRLTRNVTKDHIMEIFSTYGKIKMIDMPVERMH 198

  Fly   761 KQF-KGIAYVEFEKPGEAQRAVAGRDGCLFKGMNISVAI-----SNPPPRGTSAVKPSVAPKRRV 819
            ... ||.||||||.|.||::|:...||....|..|:...     ..||||..|      .|:|.:
Human   199 PHLSKGYAYVEFENPDEAEKALKHMDGGQIDGQEITATAVLAPWPRPPPRRFS------PPRRML 257

  Fly   820 P 820
            |
Human   258 P 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rnp4F	NP_511047.2	RRM_SF	722..802	CDD:473069	26/86 (30%)
		2A1904	<860..>925	CDD:273344
		Lsm_interact	922..940	CDD:398843
RNPS1	NP_006702.1	Necessary for interaction with the cleaved p110 isoform of CDC2L1	1..220		45/215 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..170		26/165 (16%)
		Necessary for interaction with SRP54, nuclear localization and exon-skipping. /evidence=ECO:0000269|PubMed:14729963	1..161		24/156 (15%)
		Necessary for interactions with UPF2 and UPF3B and UPF2-dependent NMD	69..121		6/51 (12%)
		Necessary for interaction with PNN and exon-skipping	156..242		27/85 (32%)
		Interaction with SAP18 and ACIN1. /evidence=ECO:0000269|PubMed:20966198	159..244		26/84 (31%)
		RRM_RNPS1	163..236	CDD:409800	25/72 (35%)
		Necessary for interaction with TRA2B, nuclear localization and exon-skipping. /evidence=ECO:0000269|PubMed:14729963	238..305		8/27 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..305		8/25 (32%)