DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sas10 and Utp3

DIOPT Version :9

Sequence 1:	NP_572215.1	Gene:	Sas10 / 31447	FlyBaseID:	FBgn0029755	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_075541.1	Gene:	Utp3 / 65961	MGIID:	1919230	Length:	469	Species:	Mus musculus

Alignment Length:	448	Identity:	172/448 - (38%)
Similarity:	254/448 - (56%)	Gaps:	38/448 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDGD-DYVMSGSDQEYDDEEREILE---DLRKQRKKPHDPVQEVLGFSDDDDDDDDDDEEEQQDV 63
            |.|| .|.....|:.::...|.:|.   :..:..::..|..:|||....||.||:|.:..|:::|
Mouse    37 SPGDSSYYQDQVDEFHEARSRAVLAKGWNEVESGEEDGDEEEEVLPLDIDDGDDEDGESSEEEEV 101

  Fly    64 AELMRDSDIEGA----EDDDRDLPNTMDWGSKRSTYYNTDFVDQDYSSYNAQE-EEQARAEEEEA 123
            .|     |.:|.    .:.:..:..::.||.::..||:||:..:.....:.|| ||:.|.|||||
Mouse   102 GE-----DDDGGSSVQSEAEASVDPSLSWGQRKKLYYDTDYGSKSRGRQSQQEVEEEEREEEEEA 161

  Fly   124 KKIQLRLAKRMSEADFQLDNVE--AAPAGSSDDNELSHITKVTSDLAGLSERERRQLMHSESPEF 186
            :.||.|||:.:.|.||.:..||  |.|....|:.|    |:|..|||.:|.:|:.:::..||||.
Mouse   162 QIIQRRLAQALQEDDFGVAWVEAFAKPVPQVDEAE----TRVVKDLAKVSVKEKLKMLKKESPEL 222

  Fly   187 IILTQDFQQHLDEVKNLLKPVLNYVRKHDVPMVPALQYAGLCHTVLTTYCSNVAFYLLLKARRID 251
            :.|.:|.|..|.|||:.|:|:|..|.|..:|.....:|....:.:...||:|::|||:|||||:.
Mouse   223 LELIEDLQAKLTEVKDELEPLLQLVEKGVIPTGRGSEYLKTKYNLYLNYCANISFYLILKARRVP 287

  Fly   252 VKAHPVIRRLVQLKDLIEELKPRYEEYIRPQLEALLERIEDGDAFTVLDVAQRKAKLQILNKYND 316
            ...||||.|||..::||.:|.. .::.:..::..|| ..:||   .|......||||......:.
Mouse   288 AHGHPVIERLVTYRNLINKLSV-VDQKLSSEIRHLL-TAKDG---AVKKEMTPKAKLTKTKPKSV 347

  Fly   317 GQQASVSSDDDDNDD----------DDDAESKEKDLQEEAGEEE--EEEDARRGITYQMAKNKGL 369
            .|.|:|:..|:.:.|          :|..|.|.|. :|.:.||:  ||::|:|.||||:|||:||
Mouse   348 KQAAAVALTDEPDFDGAALKYYKEMEDRQELKRKK-EENSAEEQALEEQNAKRAITYQIAKNRGL 411

  Fly   370 TPHRKKELRNPRVKHRGKYRKALIRRKGAVRTVRKELQRYGGELSGIKAGVTKSVKFR 427
            ||.|||..||||||||.|:|||.|||:|.||.||:|.|||.||||||:|||.||:|.:
Mouse   412 TPRRKKIDRNPRVKHREKFRKAKIRRRGQVREVRREEQRYSGELSGIRAGVKKSIKLK 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sas10	NP_572215.1	Sas10_Utp3	191..269	CDD:281929	32/77 (42%)
Sas10	NP_572215.1	Sas10	354..426	CDD:286457	51/71 (72%)
Utp3	NP_075541.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..44		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..158		25/100 (25%)
		Sas10_Utp3	226..305	CDD:281929	32/78 (41%)
		Sas10	398..468	CDD:286457	50/69 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..469		43/58 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848483
Domainoid	1	1.000	106	1.000	Domainoid score	I6596
eggNOG	1	0.900	-	-		E1_KOG3118
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10681
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3105
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004426
OrthoInspector	1	1.000	-	-		oto94273
orthoMCL	1	0.900	-	-		OOG6_104545
Panther	1	1.100	-	-	LDO	PTHR13237
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1729
SonicParanoid	1	1.000	-	-		X6319
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.780