DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sas10 and UTP3

DIOPT Version :9

Sequence 1:	NP_572215.1	Gene:	Sas10 / 31447	FlyBaseID:	FBgn0029755	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_065101.1	Gene:	UTP3 / 57050	HGNCID:	24477	Length:	479	Species:	Homo sapiens

Alignment Length:	449	Identity:	165/449 - (36%)
Similarity:	253/449 - (56%)	Gaps:	58/449 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GDDYVMSGSDQEYDDEEREILEDLRKQRKKPHDPVQEVLGFSDDDDDDDDDDEEEQQDVAELMRD 69
            |.:.|.||.:::.::||.|:|                .|...|:||:|..:..||:::
Human    63 GWNEVQSGDEEDGEEEEEEVL----------------ALDMDDEDDEDGGNAGEEEEE------- 104

  Fly    70 SDIEGAEDD---------DRDLPNTMDWGSKRSTYYNTDFVDQDYSSYNAQE-EEQARAEEEEAK 124
               |.|:||         :..:..::.||.::..||:||:..:.....:.|| ||:.|.|||||:
Human   105 ---ENADDDGGSSVQSEAEASVDPSLSWGQRKKLYYDTDYGSKSRGRQSQQEAEEEEREEEEEAQ 166

  Fly   125 KIQLRLAKRMSEADFQLDNVE--AAPAGSSDDNELSHITKVTSDLAGLSERERRQLMHSESPEFI 187
            .||.|||:.:.|.||.:..||  |.|....|:.|    |:|..|||.:|.:|:.:::..||||.:
Human   167 IIQRRLAQALQEDDFGVAWVEAFAKPVPQVDEAE----TRVVKDLAKVSVKEKLKMLRKESPELL 227

  Fly   188 ILTQDFQQHLDEVKNLLKPVLNYVRKHDVPMVPALQYAGLCHTVLTTYCSNVAFYLLLKARRIDV 252
            .|.:|.:..|.|||:.|:|:|..|.:..:|.....||....:.:...||||::|||:|||||:..
Human   228 ELIEDLKVKLTEVKDELEPLLELVEQGIIPPGKGSQYLRTKYNLYLNYCSNISFYLILKARRVPA 292

  Fly   253 KAHPVIRRLVQLKDLIEELKPRYEEYIRPQLEALLERIEDGDAFTVLDVAQ-RKAKLQILNKYND 316
            ..||||.|||..::||.:|.. .::.:..::..||...:|.....::..|: .|.|.:.::| ..
Human   293 HGHPVIERLVTYRNLINKLSV-VDQKLSSEIRHLLTLKDDAVKKELIPKAKSTKPKPKSVSK-TS 355

  Fly   317 GQQASVSSDDDDNDDDDDAESK-----------EKDLQEEAGEEE--EEEDARRGITYQMAKNKG 368
            ....:|:...||:|.|:.|:.|           ::..:|.:.||:  |:::|:|.||||:|||:|
Human   356 AAACAVTDLSDDSDFDEKAKLKYYKEIEDRQKLKRKKEENSTEEQALEDQNAKRAITYQIAKNRG 420

  Fly   369 LTPHRKKELRNPRVKHRGKYRKALIRRKGAVRTVRKELQRYGGELSGIKAGVTKSVKFR 427
            |||.|||..||||||||.|:|:|.|||:|.||.||||.|||.||||||:|||.||:|.:
Human   421 LTPRRKKIDRNPRVKHREKFRRAKIRRRGQVREVRKEEQRYSGELSGIRAGVKKSIKLK 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sas10	NP_572215.1	Sas10_Utp3	191..269	CDD:281929	32/77 (42%)
Sas10	NP_572215.1	Sas10	354..426	CDD:286457	51/71 (72%)
UTP3	NP_065101.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..166		34/128 (27%)
		Sas10_Utp3	230..309	CDD:309214	32/78 (41%)
		Sas10	408..478	CDD:312764	50/69 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..466		33/46 (72%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158101
Domainoid	1	1.000	106	1.000	Domainoid score	I6625
eggNOG	1	0.900	-	-		E1_KOG3118
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10681
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3172
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1451774at2759
OrthoFinder	1	1.000	-	-		FOG0004426
OrthoInspector	1	1.000	-	-		oto90686
orthoMCL	1	0.900	-	-		OOG6_104545
Panther	1	1.100	-	-	LDO	PTHR13237
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1729
SonicParanoid	1	1.000	-	-		X6319
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790