DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sas10 and utp3

DIOPT Version :9

Sequence 1:	NP_572215.1	Gene:	Sas10 / 31447	FlyBaseID:	FBgn0029755	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001004595.1	Gene:	utp3 / 447856	ZFINID:	ZDB-GENE-040912-163	Length:	470	Species:	Danio rerio

Alignment Length:	441	Identity:	169/441 - (38%)
Similarity:	247/441 - (56%)	Gaps:	61/441 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SDQEYDDEEREILEDLRKQRKKPHDPVQEVLGFSDDDDD-------DDDDDEEEQQDVAELMRDS 70
            ||:|.:|:..|::            |:  .|..||:|||       |||||||:..|:     :|
Zfish    65 SDEEDEDKAVEVM------------PL--TLSESDEDDDEEKEEEEDDDDDEEDGTDM-----ES 110

  Fly    71 DIEGAEDDDRDLPNTMDWGSKRSTYYNTDFVDQDYSSYNAQEEEQARAEEEEAKKIQLRLAKRMS 135
            |:||.:||  ||||.:.||:|:..:|:||:..:...|....|.|. :.||:||.|||.|||.::|
Zfish   111 DLEGKKDD--DLPNDLAWGNKKKIFYDTDYATKKGKSLEEIEAED-KEEEDEATKIQKRLAAKLS 172

  Fly   136 EADFQLDNVEAAPAGSSDDNELSHITKVTSDLAGLSERERRQLMHSESPEFIILTQDFQQHLDEV 200
            |.|:.|:.:|.....:..:.|:....::..||..||::|:.:|:..||||.:.|.|||:..|.|:
Zfish   173 EEDYDLNLLEEFVVDAEVEKEVKKEERIVKDLKTLSQKEKLKLLKKESPELLELIQDFKAKLTEL 237

  Fly   201 KNLLKPVLNYVRKHDVPMVPALQYAGLCHTVLTTYCSNVAFYLLLKARRIDVKAHPVIRRLVQLK 265
            ::.::|::..|:...:|......|......:...||:|::|||:|||:||....||||.||:..:
Zfish   238 RDEVQPLVKMVKNGRIPPGKGANYIITKQQLYLNYCTNISFYLVLKAKRIPAHNHPVIERLLTYR 302

  Fly   266 DLIEELKPRYEEYIRPQLEALL-----ERIE---DGDAFTVLDVAQRKAKLQILNKYNDGQQASV 322
            :||.|| ...:..:.|||..||     :|:.   .|...|.|   ..||.|         ::|..
Zfish   303 NLINEL-GAVDARLAPQLRQLLSGEKPDRLPKRLPGSKHTKL---TEKAGL---------EEAEE 354

  Fly   323 SSDDDDND--------DDDDAESKEKDLQEEAGEEEEEE---DARRGITYQMAKNKGLTPHRKKE 376
            |..|::.:        :....:.|:.::|.|...||.||   ||:|.|||:|:|||||||.|||.
Zfish   355 SESDEEANLRFYNAMAEKQKLKRKKSEMQNEDKLEENEEMEGDAKRRITYEMSKNKGLTPKRKKI 419

  Fly   377 LRNPRVKHRGKYRKALIRRKGAVRTVRKELQRYGGELSGIKAGVTKSVKFR 427
            .||||||||.|:|:|.|||||.||.||.|..||.||.|||:|||.:|||.:
Zfish   420 DRNPRVKHREKFRRAQIRRKGQVREVRHEEARYSGEWSGIRAGVKRSVKLK 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sas10	NP_572215.1	Sas10_Utp3	191..269	CDD:281929	27/77 (35%)
Sas10	NP_572215.1	Sas10	354..426	CDD:286457	50/71 (70%)
utp3	NP_001004595.1	Sas10_Utp3	227..306	CDD:281929	27/78 (35%)
utp3	NP_001004595.1	Sas10	397..469	CDD:286457	50/71 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593974
Domainoid	1	1.000	106	1.000	Domainoid score	I6552
eggNOG	1	0.900	-	-		E1_KOG3118
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10681
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3115
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1451774at2759
OrthoFinder	1	1.000	-	-		FOG0004426
OrthoInspector	1	1.000	-	-		oto39788
orthoMCL	1	0.900	-	-		OOG6_104545
Panther	1	1.100	-	-	LDO	PTHR13237
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1729
SonicParanoid	1	1.000	-	-		X6319
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790