DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sas10 and Utp3

DIOPT Version :9

Sequence 1:	NP_572215.1	Gene:	Sas10 / 31447	FlyBaseID:	FBgn0029755	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001012036.1	Gene:	Utp3 / 305258	RGDID:	1308540	Length:	470	Species:	Rattus norvegicus

Alignment Length:	442	Identity:	166/442 - (37%)
Similarity:	242/442 - (54%)	Gaps:	67/442 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SDQEYDDEEREILEDLRKQRKKPHDPVQEVLGFSDDDDDDDDDDEEEQQDVAELMRDSDIEGAED 77
            |.:|.||||.|:|            |:.     .||::|:|.:..||::|            .||
  Rat    69 SGEEDDDEEEEVL------------PLN-----IDDENDEDGESSEEEED------------GED 104

  Fly    78 DD----------RDLPNTMDWGSKRSTYYNTDFVDQDYSSYNAQE-EEQARAEEEEAKKIQLRLA 131
            ||          ..:..::.||.::..||:||:..:.....:.|| ||:.|.|||||:.||.||.
  Rat   105 DDGGSSVQSEAEASVDPSLSWGQRKRLYYDTDYGSKSRGRQSQQEVEEEEREEEEEAQVIQRRLT 169

  Fly   132 KRMSEADFQLDNVE--AAPAGSSDDNELSHITKVTSDLAGLSERERRQLMHSESPEFIILTQDFQ 194
            :.:.|.||.:..||  |.|....|:.|    |:|..|||.:|.:|:.:::..||||.:.|.:|.:
  Rat   170 QALQEDDFGVAWVEAFAKPVPQVDEAE----TRVVKDLAKVSVKEKLKMLRKESPELLELIEDLK 230

  Fly   195 QHLDEVKNLLKPVLNYVRKHDVPMVPALQYAGLCHTVLTTYCSNVAFYLLLKARRIDVKAHPVIR 259
            ..|.|||:.|:|::..|.|..:|.....||....:.:...||:|::|||:|||||:....||||.
  Rat   231 VKLTEVKDELEPLIQLVEKGVIPPGKGSQYLKTKYNLYLNYCANISFYLILKARRVPAHGHPVIE 295

  Fly   260 RLVQLKDLIEELKPRYEEYIRPQLEALLERIEDGDAFTVLDVAQRKAKLQILNKYNDGQQASVSS 324
            |||..::||.:|.. .::.:..::..||...|......:    ..|||| ...|....:|..|::
  Rat   296 RLVTYRNLINKLSV-VDQKLSSEIRHLLTAKEGAGKKDL----NPKAKL-TKTKPKSAKQTDVNA 354

  Fly   325 DDDDNDDDDDA------------ESKEKDLQEEAGEEE--EEEDARRGITYQMAKNKGLTPHRKK 375
            |..:..:.|:|            |.|.|. :|.:.||:  ||::|:|.||||:|||:||||.|||
  Rat   355 DLTEEPEFDEAALEFYKEMEDRPELKRKK-EENSAEEQALEEQNAKRAITYQIAKNRGLTPRRKK 418

  Fly   376 ELRNPRVKHRGKYRKALIRRKGAVRTVRKELQRYGGELSGIKAGVTKSVKFR 427
            ..||||||||.|:|:|.|||:|.||.||:|.|||.||||||:|||.||:|.:
  Rat   419 IDRNPRVKHREKFRRAKIRRRGQVREVRREEQRYSGELSGIRAGVKKSIKLK 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sas10	NP_572215.1	Sas10_Utp3	191..269	CDD:281929	31/77 (40%)
Sas10	NP_572215.1	Sas10	354..426	CDD:286457	50/71 (70%)
Utp3	NP_001012036.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..162		35/121 (29%)
		Sas10_Utp3	226..305	CDD:281929	31/78 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..357		8/32 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..457		49/82 (60%)
		Sas10	399..469	CDD:286457	49/69 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352083
Domainoid	1	1.000	105	1.000	Domainoid score	I6529
eggNOG	1	0.900	-	-		E1_KOG3118
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10681
Inparanoid	1	1.050	250	1.000	Inparanoid score	I3152
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1451774at2759
OrthoFinder	1	1.000	-	-		FOG0004426
OrthoInspector	1	1.000	-	-		oto97793
orthoMCL	1	0.900	-	-		OOG6_104545
Panther	1	1.100	-	-	LDO	PTHR13237
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6319
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760