DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sas10 and SPBC3B8.09

DIOPT Version :9

Sequence 1:	NP_572215.1	Gene:	Sas10 / 31447	FlyBaseID:	FBgn0029755	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_596405.1	Gene:	SPBC3B8.09 / 2541000	PomBaseID:	SPBC3B8.09	Length:	597	Species:	Schizosaccharomyces pombe

Alignment Length:	585	Identity:	145/585 - (24%)
Similarity:	233/585 - (39%)	Gaps:	190/585 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VMSGSDQEYDDEEREILE-DLRKQRKKPHDPVQEVLGFSDDDDDDDDDDEEEQQDVAELMRDSDI 72
            |.:..|:.|:.:::.:.: |..:|..:.....:|::......|::|.:.||      .|..:.::
pombe    37 VANSEDEFYNAQDKILFDADNGEQADELELSDEELVALESSSDEEDGNAEE------NLSENEEL 95

  Fly    73 EGAEDD---DRDLPNTMDWGSKRSTYYNTDFVDQDYSSYNAQEEE-QARAEEEEAKKIQLRLAKR 133
            .|.:.|   :.:|.:...||....:||..|  |.|...|:.:::| .||.||:||.::|.:..::
pombe    96 SGKKKDAVNEEELYDNKGWGRSAKSYYGGD--DYDNEDYSEEDDEFDARMEEQEALRLQRKRLEK 158

  Fly   134 MSEADFQLDNVEAAPAGSSDDNELSHITKVTSDLAGLSE-----------RERRQLMHSESPEFI 187
            :||.| .:|::    :..:|:::|..| |..|..|.:.|           .|..:::.::.||
pombe   159 VSETD-AIDDI----SQWADNSDLKSI-KQDSSAAAIEELVQQISPDLPRTELLKILEAKHPE-- 215

  Fly   188 ILTQDFQQHLDEVKNLLKPVLNYVRKHDVPMVPALQYAGLCHTVLTTYCSNVAFYL-LLKARRID 251
                 ||..|||: |.|||.||.: |..:...|:.|......|.|:||.|.:.||. |||....|
pombe   216 -----FQLFLDEL-NQLKPQLNEI-KEKLKTYPSSQLLQAQCTALSTYISFLTFYFALLKDGEED 273

  Fly   252 VKAHPVIRRLVQLKD-------LIEELKPRYEEYIRPQLEA--------------------LLER 289
            :|.||::..||:.|.       |.|.|.|...|.....:|.                    :.|.
pombe   274 LKNHPIMVDLVRCKQTWESYCGLDEVLTPTSLEEDGKTIELHEKIASASDIGASEDEEDVDMHES 338

  Fly   290 IEDGDAFTVLD--VAQ--------RKAKLQI------LNKYNDG--------------------- 317
            |.|.:...:.|  ||:        |.||.:|      |:.|.:|
pombe   339 ISDNENEGIKDIPVAEDDDITLKFRAAKSKINTNIKNLDDYGEGNRLDDVDAEDKIARKRSLKFY 403

  Fly   318 -----------------------------------------------QQASVSSDDDD------- 328
                                                           |.|....||:|
pombe   404 ANQIDQKAAKRSRAVLELSGDLDMPYKERRFERQQRLMREAAARGRNQDAGADLDDEDPESMGIP 468

  Fly   329 -------NDDDD-------DAESK-EKDLQEEAGEEEEE--------------EDARRGITYQMA 364
                   .|.||       |.:|| .|.|::|..:.|.:              |..:||||..:|
pombe   469 ANVDREVEDQDDLDYYESLDKKSKMAKKLRKENHDLERDLIRASRHPELIELGEGDKRGITLDIA 533

  Fly   365 KNKGLTPHRKKELRNPRVKHRGKYRKALIRRKGAVRTVRKELQR--YGGELSGIKAGVTKSVKFR 427
            ||:||||.|.||.||||:|.|.:|.||. ::..:.:.:.|...:  |.||.:|||||:.||:|.:
pombe   534 KNRGLTPRRPKENRNPRLKKRMRYEKAK-KKLASKKAIYKGAPQGGYAGEQTGIKAGLVKSIKLQ 597

Fly 428 427
pombe 598 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sas10	NP_572215.1	Sas10_Utp3	191..269	CDD:281929	32/85 (38%)
Sas10	NP_572215.1	Sas10	354..426	CDD:286457	34/73 (47%)
SPBC3B8.09	NP_596405.1	Sas10_Utp3	219..291	CDD:281929	29/73 (40%)
SPBC3B8.09	NP_596405.1	Sas10	522..596	CDD:286457	35/74 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	66	1.000	Domainoid score	I2809
eggNOG	1	0.900	-	-		E1_KOG3118
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I1812
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004426
OrthoInspector	1	1.000	-	-		oto101628
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13237
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1729
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.950