Protein Alignment CG15930 and TDRD5

DIOPT Version :10

• Sequence 1: NP_572214.2
• Gene: CG15930 / 31446
• FlyBaseID: FBgn0029754
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_001186014.1
• Gene: TDRD5 / 163589
• HGNCID: 20614
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 108/534 - (20%)
• Similarity: 177/534 - (33%)
• Gaps: 156/534 - (29%)

  Fly     5 MDVKEGRLQTLLSKLRKISEE-------------------AEDNNDVPLDLRC---PSAKMRNNK 47
            :.|::.|..:||...:.::||                   ...:...|:...|   |::.|...|
Human   186 ISVEQTRAGSLLMLKKSVTEEKPRGCPAGKIFTQPFRMKQGSYSTGFPVAKPCFSQPTSNMEPPK 250

  Fly    48 VLADL--SDMLKVVEDIALE--EKTTDSKKPANSE-QQI--NGTIELALDLRQPNAKIRLVISD- 104
            .:..:  :..|.|||...|.  ||....:....|. .||  .|||...|     ..||:.|:|.
Human   251 QIMSMEKTSKLNVVETSRLNHTEKLNQLENTFKSVIAQIGPGGTISSEL-----KHKIKFVVSKF 310

  Fly   105 -------------------------------------SSDLQKV-FEKAHIALELKTTDSKPTAE 131
                                                 .||:..| |.|.|..|.:...|.||
Human   311 PEGLFISKLLGEYEVIFKEQLSPKKLGFLNVTELVGALSDILHVEFRKGHQDLLVFDADKKP--- 372

  Fly   132 TDDQHHVRIFDKMLCNIVVPPDVADVQVNGK-----PLEQLLATVSERQAMNNPGPMKMHELHTG 191
                              :||..:|.::..|     |....|:|.:.::.:.|....|..|  ..
Human   373 ------------------LPPVQSDKKIEAKACVSSPPRNSLSTAAVKETVWNCPSKKQKE--PQ 417

  Fly   192 NADFMNSNSQVAEAAASVETLLASTSDNDSDSDGLESKTTDGYIVKELIPSFSDFPDIGDVSLCA 256
            .......|..|......|||       |.|                             :::|..
Human   418 QKICKKPNLVVKPLQLQVET-------NKS-----------------------------ELNLAM 446

  Fly   257 LMYGLPMDAVGMH--WKLPPQRIQDICKEDSIFPIIMSCVFSPCEFWFHIVPPQYAKNP---VAE 316
            ..:.:|.|||...  .:|||      ....|:..:.:..:.||.:|:..|    |:::.   :.:
Human   447 ANHDIPPDAVPNKKLCRLPP------LDTSSLIGVFVEYIISPSQFYIRI----YSRDSSELLED 501

  Fly   317 MTIDLNWFYRHTTISSYRAELPSYFYKEGYICAA-YSECGWRRAMVLVTAPLDAQCVNIEYVDHA 380
            |.|::...|.:..:|. |..:|..|.:.|::|.. .||..| ...|::...|:.|.|.:.|.|..
Human   502 MMIEMRRCYSNQLVSD-RYVMPECFIQPGHLCCVRISEDKW-WYRVIIHRVLEKQEVEVFYPDFG 564

  Fly   381 LSVTLAPNHLRFLPLSFARTPPLVFRGKMSHVRPLANGWPKNGITAFQRMTFNRVLYAHVGE-LD 444
            ....:..:.||||...:.:.|.......::.|||:...|....|..||::...:.|...|.| :|
Human   565 NIGIVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPVEEHWTSKAILQFQKLCGLKPLVGVVDEYVD 629

  Fly   445 TAQGIFSMRLSYDE 458
            ....||....|.:|
Human   630 GILNIFLCDTSSNE 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15930	NP_572214.2	TUDOR	285..411	CDD:425754	29/129 (22%)
TDRD5	NP_001186014.1	LOTUS_1_TDRD5	4..98	CDD:193599
		LOTUS_2_TDRD5	132..201	CDD:193589	4/14 (29%)
		LOTUS_3_TDRD5	296..369	CDD:193590	12/77 (16%)
		Tudor_TDRD5	476..593	CDD:410490	28/122 (23%)