DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15930 and TDRKH

DIOPT Version :9

Sequence 1:	NP_572214.2	Gene:	CG15930 / 31446	FlyBaseID:	FBgn0029754	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001077432.1	Gene:	TDRKH / 11022	HGNCID:	11713	Length:	561	Species:	Homo sapiens

Alignment Length:	470	Identity:	93/470 - (19%)
Similarity:	152/470 - (32%)	Gaps:	143/470 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GRLQTLLSKLRK-----ISEEAEDNND--------VPLDLRCPSAKMRNNKVLAD---LSDMLKV 58
            ||....:.:|||     |..:.||..|        .|:.: | .||...:::|.:   :|:.|.|
Human    69 GRQGANIKQLRKQTGARIDVDTEDVGDERVLLISGFPVQV-C-KAKAAIHQILTENTPVSEQLSV 131

  Fly    59 V------------EDIALEEKTTDSKKPANSEQQINGTIELALDLRQPNAKIRLVISDSSDLQKV 111
            .            |.|....|.:.:|...:.|.:  ||:.|:          || |..|...::|
Human   132 PQRSVGRIIGRGGETIRSICKASGAKITCDKESE--GTLLLS----------RL-IKISGTQKEV 183

  Fly   112 FEKAHIALELKTTDSKPTAETDDQHHVRIFDKMLCNIVVPPDVADVQVNGKPLEQLLATVSERQA 176
            ....|:.|| |.::       |::...||...           |:.:|   |.:|.::.  .|:.
Human   184 AAAKHLILE-KVSE-------DEELRKRIAHS-----------AETRV---PRKQPISV--RRED 224

  Fly   177 MNNPGPMKMHELHTGNADFMNSNSQVAEAAASVETLLASTSDNDSD------SDGLESKTTDGYI 235
            |..||       ..|......:.|...|..|   .|:........|      .:|...|.:|...
Human   225 MTEPG-------GAGEPALWKNTSSSMEPTA---PLVTPPPKGGGDMAVVVSKEGSWEKPSDDSF 279

  Fly   236 VKELIPSFSDFPDIGDVSLCALMYGLPMDAVGMHWKLPPQRIQDICKEDSIFPIIMSCVFSPCEF 300
            .|....:..:.|          |:.:|......|             .|....:.:|....|..|
Human   280 QKSEAQAIPEMP----------MFEIPSPDFSFH-------------ADEYLEVYVSASEHPNHF 321

  Fly   301 WFHIV-------------PPQYAKNPVAE-MTIDLNWFYRHTTISSYRAELPSYFYKEGYICAAY 351
            |..||             ..|:.:|.|.| :|:.:.        ....|.||
Human   322 WIQIVGSRSLQLDKLVNEMTQHYENSVPEDLTVHVG--------DIVAAPLP------------- 365

  Fly   352 SECGWRRAMVLVTAPLDAQCVNIEYVDHALSVTLAPNHLRFLPLSFARTPPLVFRGKMSHVRPLA 416
            :...|.||.||.|  |:...:::.:||...:.......||.|...|...|.......::.:.|..
Human   366 TNGSWYRARVLGT--LENGNLDLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAPSG 428

  Fly   417 NGWPKNGITAFQRMT 431
            :.|.:..:..|.|:|
Human   429 DQWEEEALDEFDRLT 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15930	NP_572214.2	TUDOR	281..411	CDD:278965	29/143 (20%)
TDRKH	NP_001077432.1	KH-I	54..116	CDD:238053	13/48 (27%)
		KH-I	126..191	CDD:238053	17/77 (22%)
		UPF0561	<192..249	CDD:287535	17/90 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..262		10/54 (19%)
		TUDOR	303..422	CDD:278965	30/154 (19%)
		TUDOR	357..404	CDD:119391	13/69 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910