DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk7 and SNF1

DIOPT Version :9

Sequence 1:	NP_511044.1	Gene:	Cdk7 / 31441	FlyBaseID:	FBgn0263237	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_010765.3	Gene:	SNF1 / 852088	SGDID:	S000002885	Length:	633	Species:	Saccharomyces cerevisiae

Alignment Length:	359	Identity:	101/359 - (28%)
Similarity:	157/359 - (43%)	Gaps:	90/359 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKG--SREDARDGINRTALREIKILQELQHENI 74
            |..:..||||.|..|..|..|.|.|.||:|.|.|.  ::.|.:..|.    |||..|:.|:|.:|
Yeast    55 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIE----REISYLRLLRHPHI 115

  Fly    75 IGLVDVFGQLSNVSLVFDFMDTDL-EVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDL 138
            |.|.||......:.:|.::...:| :.|::.:|  :::...:.:....:..:||.|.:.|:||||
Yeast   116 IKLYDVIKSKDEIIMVIEYAGNELFDYIVQRDK--MSEQEARRFFQQIISAVEYCHRHKIVHRDL 178

  Fly   139 KPNNLLVNSDGILKIGDFGLAK----------SFGSPNRIYTHHVVTRWYRSPELLFGARQYGTG 193
            ||.|||::....:||.||||:.          |.||||           |.:||::.|....|..
Yeast   179 KPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPN-----------YAAPEVISGKLYAGPE 232

  Fly   194 VDMWAVGCIL-AELMLRVPFMPGDSDLDQLTRIFSTL--GTPTEAEWPHLSKLHDYLQFRNFPGT 255
            ||:|:.|.|| ..|..|:||     |.:.:..:|..:  |..|         |..:|.    ||
Yeast   233 VDVWSCGVILYVMLCRRLPF-----DDESIPVLFKNISNGVYT---------LPKFLS----PG- 278

  Fly   256 PLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMPSAIL------ 314
                   |||     |::|:..:|||.|:|..|.:...:|          |:.:|..:|
Yeast   279 -------AAG-----LIKRMLIVNPLNRISIHEIMQDDWF----------KVDLPEYLLPPDLKP 321

  Fly   315 ----------AAKEGANPQTGDTKPALKRKLVET 338
                      :.|:|::|...:....|...|..|
Yeast   322 HPEEENENNDSKKDGSSPDNDEIDDNLVNILSST 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	PTZ00024	6..308	CDD:240233	93/311 (30%)
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	93/311 (30%)
SNF1	NP_010765.3	STKc_AMPK_alpha	52..306	CDD:270981	91/298 (31%)
		UBA_2	344..389	CDD:400760	3/12 (25%)
		AdenylateSensor	504..626	CDD:406881
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000