DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk7 and KIN28

DIOPT Version :9

Sequence 1:	NP_511044.1	Gene:	Cdk7 / 31441	FlyBaseID:	FBgn0263237	Length:	353	Species:	Drosophila melanogaster
Sequence 2:	NP_010175.1	Gene:	KIN28 / 851450	SGDID:	S000002266	Length:	306	Species:	Saccharomyces cerevisiae

Alignment Length:	305	Identity:	136/305 - (44%)
Similarity:	200/305 - (65%)	Gaps:	12/305 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENIIG 76
            |.|...:|||.:|.||......|.:.:|:|:||   ..:.:||::.:|:||:|.|||:||.|:|.
Yeast     7 YTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIK---TSEFKDGLDMSAIREVKYLQEMQHPNVIE 68

  Fly    77 LVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPN 141
            |:|:|....|::||.:|:.|||||:|||..|:.|.|:|||:.:|||:|:.:.|.|:|||||||||
Yeast    69 LIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPN 133

  Fly   142 NLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAEL 206
            |||.:.||.:|:.|||||::..:|:.|.|.:|||||||:|||||||:.|.:.:|:|:||.|.|||
Yeast   134 NLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAEL 198

  Fly   207 MLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPGTPLDNI---FTAAGNDL 268
            |||:|::||.:|:||:...|..|||||:.:||.:|....|.:.:.:|....|.:   |.||....
Yeast   199 MLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYA 263

  Fly   269 IHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMPSAI 313
            :..|..:..|||.:|.:..:.|...||...|.|:      .||:|
Yeast   264 LDFMCGMLTMNPQKRWTAVQCLESDYFKELPPPS------DPSSI 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	PTZ00024	6..308	CDD:240233	133/298 (45%)
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	133/298 (45%)
KIN28	NP_010175.1	STKc_CDK7	7..302	CDD:270833	135/303 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342209
Domainoid	1	1.000	270	1.000	Domainoid score	I280
eggNOG	1	0.900	-	-		E1_KOG0659
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1363
Inparanoid	1	1.050	276	1.000	Inparanoid score	I579
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003675
OrthoInspector	1	1.000	-	-		oto99085
orthoMCL	1	0.900	-	-		OOG6_103547
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R249
SonicParanoid	1	1.000	-	-		X2548
TreeFam	1	0.960	-	-
	14	13.780