Protein Alignment Cdk7 and CDK15

DIOPT Version :10

• Sequence 1: NP_511044.1
• Gene: Cdk7 / 31441
• FlyBaseID: FBgn0263237
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_001353315.1
• Gene: CDK15 / 65061
• HGNCID: 14434
• Length: 435
• Species: Homo sapiens
• Alignment Length: 301
• Identity: 119/301 - (39%)
• Similarity: 170/301 - (56%)
• Gaps: 23/301 - (7%)

  Fly    12 YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENIIG 76
            |..|..||||.:|||||....:..|:||:|.|..    :|.:|:..||:||..:|:.|:|.||:.
Human   103 YLNLEKLGEGSYATVYKGISRINGQLVALKVISM----NAEEGVPFTAIREASLLKGLKHANIVL 163

  Fly    77 LVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPN 141
            |.|:......::.||::|.|||...:..:...|...|::.:....|:||.|:|...:|||||||.
Human   164 LHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQ 228

  Fly   142 NLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAEL 206
            |||::..|.||:.|||||::...|::.|:..|||.|||.|:.|.||.:|.:.:|:|..|||..|:
Human   229 NLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEM 293

  Fly   207 MLRVPFMPGDSD-LDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRN---FP-GTP--LDNIFTAA 264
            ....|..||.|: |:||.:|:..||.|||..||.:|||.:|    |   || .||  |..::...
Human   294 FQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNY----NPEWFPLPTPRSLHVVWNRL 354

  Fly   265 G-----NDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPA 300
            |     .||...|.:.|   |..|||.:|||...||:..|:
Human   355 GRVPEAEDLASQMLKGF---PRDRVSAQEALVHDYFSALPS 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	119/301 (40%)
CDK15	NP_001353315.1	STKc_PFTAIRE2	102..387	CDD:270852	116/294 (39%)