Protein Alignment Cdk7 and CDK20

DIOPT Version :10

• Sequence 1: NP_511044.1
• Gene: Cdk7 / 31441
• FlyBaseID: FBgn0263237
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: XP_047279074.1
• Gene: CDK20 / 23552
• HGNCID: 21420
• Length: 364
• Species: Homo sapiens
• Alignment Length: 336
• Identity: 130/336 - (38%)
• Similarity: 188/336 - (55%)
• Gaps: 27/336 - (8%)

  Fly    10 ERYAKLSFLGEGQFATVYKARDT-------------VTNQIVAVKKIKKGSREDARDGINRTALR 61
            ::|..|..:|||....|:||:..             .|.:|||:||:.....|   ||....|||
Human     2 DQYCILGRIGEGAHGIVFKAKHVEPRVGWQCLPSILQTGEIVALKKVALRRLE---DGFPNQALR 63

  Fly    62 EIKILQELQ-HENIIGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGL 125
            |||.|||:: ::.::.|..||.......|.|:||.:||..:::..:..|.||.:|:|..|.|||:
Human    64 EIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGV 128

  Fly   126 EYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSP--NRIYTHHVVT-----RWYRSPEL 183
            .:.|.|.|:||||||.|||:::.|.|||.|||||:.| ||  :|:|||.|.|     ||||:|||
Human   129 AFCHANNIVHRDLKPANLLISASGQLKIADFGLARVF-SPDGSRLYTHQVATSPLPRRWYRAPEL 192

  Fly   184 LFGARQYGTGVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDY-- 246
            |:|||||..|||:|:||||:.||:...|..||.:|::||..:...||||....||.|::|.||
Human   193 LYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNK 257

  Fly   247 LQFRNFPGTPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYFANKPAPTVGPKLPMPS 311
            :.|:.....||:.:........:.|:.:.....|.:|::..:||...||...|.|....:||:|.
Human   258 ISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQ 322

  Fly   312 AILAAKEGANP 322
            .:......|:|
Human   323 RLGGPAPKAHP 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	125/319 (39%)
CDK20	XP_047279074.1	STKc_CCRK	3..307	CDD:270826	122/307 (40%)