Protein Alignment Cdk7 and CDK5

DIOPT Version :10

• Sequence 1: NP_511044.1
• Gene: Cdk7 / 31441
• FlyBaseID: FBgn0263237
• Length: 353
• Species: Drosophila melanogaster
• Sequence 2: NP_004926.1
• Gene: CDK5 / 1020
• HGNCID: 1774
• Length: 292
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 132/293 - (45%)
• Similarity: 187/293 - (63%)
• Gaps: 11/293 - (3%)

  Fly    10 ERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENI 74
            ::|.||..:|||.:.||:||::..|::|||:|:::   .:|..:|:..:|||||.:|:||:|:||
Human     2 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVR---LDDDDEGVPSSALREICLLKELKHKNI 63

  Fly    75 IGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLK 139
            :.|.||......::|||:|.|.||:.........|....:|::....||||.:.|...:||||||
Human    64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLK 128

  Fly   140 PNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILA 204
            |.|||:|.:|.||:.|||||::||.|.|.|:..|||.|||.|::||||:.|.|.:|||:.|||.|
Human   129 PQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFA 193

  Fly   205 ELM-LRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPG-TPLDNI---FTAA 264
            ||. ...|..||:...|||.|||..||||||.:||.::||.||..:..:|. |.|.|:   ..|.
Human   194 ELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNAT 258

  Fly   265 GNDLIHLMQRLFAMNPLRRVSCREALSMPYFAN 297
            |.|   |:|.|...||::|:|..|||..|||::
Human   259 GRD---LLQNLLKCNPVQRISAEEALQHPYFSD 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk7	NP_511044.1	STKc_CDK7	11..308	CDD:270833	132/292 (45%)
CDK5	NP_004926.1	STKc_CDK5	3..286	CDD:143344	130/288 (45%)