Protein Alignment Rpn13R and ADRM1

DIOPT Version :10

• Sequence 1: NP_572205.1
• Gene: Rpn13R / 31433
• FlyBaseID: FBgn0029745
• Length: 324
• Species: Drosophila melanogaster
• Sequence 2: NP_008933.2
• Gene: ADRM1 / 11047
• HGNCID: 15759
• Length: 407
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 115/386 - (29%)
• Similarity: 177/386 - (45%)
• Gaps: 82/386 - (21%)

  Fly     4 SNAHNLVEYKAGRMVLLGKMVEPDDRKGLLFVRRSADDNQLHIHWMDRRSGSVELDIVATPGVLE 68
            ||.: |||::||:|.|.|..|.||.||||:::::: ||:.:|..|.||.||:||.|::..|...|
Human    19 SNKY-LVEFRAGKMSLKGTTVTPDKRKGLVYIQQT-DDSLIHFCWKDRTSGNVEDDLIIFPDDCE 81

  Fly    69 FRRIDQCKTGRVYVLKYTRSTQRYFFWMQELQADGDALFCQRVNELI----------ASGERQRD 123
            |:|:.||.:|||||||:...::|.||||||.:.|.|...|::|||.:          |||. ...
Human    82 FKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGS-SGH 145

  Fly   124 EIAA--AEGDMDT---DADHTTARR-----------GFGGSENPQILEEMLVETQATWLPANRSL 172
            |::|  .||.:.:   :..|:...:           |.|....|.:...:    .::..|.:.|.
Human   146 ELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLL----GSSGPPGSSSS 206

  Fly   173 NHWQTGDAMEEP----------PLPFADPDANTDTDTDTYTSESG----------IQTFDLAAVL 217
            :..::..|...|          |.|.|...|:..:.:...:|.:|          ||..||.::|
Human   207 SSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSIL 271

  Fly   218 RL-------HGAEAVD-----------KVLSCPSRREKLMAQLPKDHEAMDEQSDILEHLHSAQF 264
            ..       .|.:.||           .:|:....:|:|:..||..........:|...|.|.||
Human   272 ATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQF 336

  Fly   265 YESLSSFSVGLHSGALRKSLEPLL-QSDDNREALNAAQVGDVERFLRELERN------DGD 318
            .::|..||..|.||    .|.||: |.....||:.||..||||.|.:.::.|      :||
Human   337 QQALGMFSAALASG----QLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGD 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpn13R	NP_572205.1	PH_Rpn13	10..115	CDD:270124	51/104 (49%)
		RPN13_C	209..312	CDD:465170	36/121 (30%)
ADRM1	NP_008933.2	PH_Rpn13	24..128	CDD:270124	51/104 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..259		10/68 (15%)
		Interaction with UCHL5. /evidence=ECO:0000269|PubMed:20471946	253..407		40/145 (28%)
		RPN13_C	274..381	CDD:465170	32/110 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..407		3/15 (20%)