DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fos and kay

DIOPT Version :9

Sequence 1:	NP_071533.1	Gene:	Fos / 314322	RGDID:	2626	Length:	380	Species:	Rattus norvegicus
Sequence 2:	NP_001027577.2	Gene:	kay / 3772082	FlyBaseID:	FBgn0001297	Length:	755	Species:	Drosophila melanogaster

Alignment Length:	411	Identity:	118/411 - (28%)
Similarity:	162/411 - (39%)	Gaps:	114/411 - (27%)

- Green bases have known domain annotations that are detailed below.

  Rat     7 NADY-------EASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNTQDFCADLSVSSANFIPTV 64
            ||.|       |..::..|||..  ||.||......:.|..|..||             ||...:
  Fly   326 NASYNDTQMNEEQDTTDTSSAHT--DSTSYQAGHIMAGSVNGGGVN-------------NFSNVL 375

  Rat    65 TAISTSPDLQWLVQPTLVSSVAPSQTRAPHPYGLPTPSTGAYARAGVVKTMSGGRAQSIGRRGKV 129
            .|:|:|..         .:||..|.....:     ||     ||.|      |||     |..:.
  Fly   376 AAVSSSRG---------SASVGSSNANTSN-----TP-----ARRG------GGR-----RPNRS 410

  Rat   130 EQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLE 194
            ..::||||:||.:||||||.|||:||.||.:.|:.|..|.:|||....:::.||..|...|.:||
  Fly   411 TNMTPEEEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEVLTNSKNQLE 475

  Rat   195 FILAAHRPAC-KIPNDLGFPEEMSVTS---LDLTGGLPEATTPESEEA----------------- 238
            ::||.||..| ||.:|:     :||.:   |....||..|.:..|..:
  Fly   476 YLLATHRATCQKIRSDM-----LSVVTCNGLIAPAGLLSAGSSGSGASSHHNHNSNDSSNGTITG 535

  Rat   239 --FTLPLLNDPEPKPSLEPVKNISN--MELKAEPFDDFLFPASSRPSGSETARSVPDVDLSGSFY 299
              .||...........|:|..||.:  |.:|.||.|..:...||             :|..|
  Fly   536 MDATLNSTGRSNSPLDLKPAANIDSLLMHIKDEPLDGAIDSGSS-------------LDQDG--- 584

  Rat   300 AADWEPLHSSSLGMGPMVT----ELEPLCTPVVTCTPSCTTYTSSFVFTYPEADSFPSCAAAHRK 360
                 |..|..:.:.||.|    .|..:.||....:.|..|..:|   |.|  ..|.|.......
  Fly   585 -----PPPSKRITLPPMSTMPHVHLSTILTPTGASSGSLQTPITS---TAP--GGFGSAFPVTSN 639

  Rat   361 GSSSNEPSS--DSLSSPTLLA 379
            |||.|..:|  ::::||||.|
  Fly   640 GSSINNINSIGNNMNSPTLNA 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fos	NP_071533.1	Basic motif, required for the activation of phospholipid synthesis, but not for CDS1-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	139..159		14/19 (74%)
		bZIP_Fos	147..200	CDD:269869	23/52 (44%)
		coiled coil	147..199	CDD:269869	22/51 (43%)
		leucine zipper	165..193		9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..380		10/28 (36%)
kay	NP_001027577.2	bZIP_Fos	420..481	CDD:269869	29/60 (48%)
kay	NP_001027577.2	coiled coil	421..480	CDD:269869	27/58 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002314
OrthoInspector	1	1.000	-	-		otm46432
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23351
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.960