DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32767 and ZFP91

DIOPT Version :9

Sequence 1:	NP_001162674.1	Gene:	CG32767 / 31430	FlyBaseID:	FBgn0052767	Length:	1281	Species:	Drosophila melanogaster
Sequence 2:	NP_444251.1	Gene:	ZFP91 / 80829	HGNCID:	14983	Length:	570	Species:	Homo sapiens

Alignment Length:	748	Identity:	144/748 - (19%)
Similarity:	238/748 - (31%)	Gaps:	254/748 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 PPTAAAAAAAVAV-------------AATTAATAAAATNNSASFSSNSSSSNSNNSNHLDNQQQL 170
            ||.|.|||.|...             ||..||.||.:....|.:.....||.|.....:..||.
Human    33 PPEAVAAAPAGTTSSRVLRGGRDRGRAAAAAAAAAVSRRRKAEYPRRRRSSPSARPPDVPGQQP- 96

  Fly   171 LIQQQQQQQQHHLLNGRRIIIQATGNSSVLAASDIKEEDEEEEDPELNDENLQDIEEEAQAAEAD 235
                                 ||..:.|.:         :.::.|.|
Human    97 ---------------------QAAKSPSPV---------QGKKSPRL------------------ 113

  Fly   236 EEPETTAHLSTQVKLELEEDDEMPDEEEEEDEDDDEELQHGQLEYQISAATQTAGAATSSAAGGA 300
                        :.:|....|:.|.||:||::|              ||..|....|.|..:.|.
Human   114 ------------LCIEKVTTDKDPKEEKEEEDD--------------SALPQEVSIAASRPSRGW 152

  Fly   301 ATAGGGSQQLVQLPAGSIVSTTTHRLSVPVTEAALVQLQRRPVYISNAVGGLTAGATYVRMPAAA 365
            .:              |..|.:.|| ....|.:
Human   153 RS--------------SRTSVSRHR-DTENTRS-------------------------------- 170

  Fly   366 VISRSPMTVLNVVQQALPAT-QLILQT-QQQQTPAAAAAEQQLALALEQQRQQQEQQAQQQR--- 425
              |||....|.::.::.|.| ||.... ::.|:|...::|       |::.:::|....::.
Human   171 --SRSKTGSLQLICKSEPNTDQLDYDVGEEHQSPGGISSE-------EEEEEEEEMLISEEEIPF 226

  Fly   426 QQQQQQEQQRQQQQQQQQQQQQQAQQEQQRQQQQQLQQQQQQQQTHPVKHSASGSSSTNNNSTTN 490
            :...:.|..:...:::..:.::::.:.::.:::::::.:.:.:......................
Human   227 KDDPRDETYKPHLERETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEEENEIREDEEPPRKRGRRR 291

  Fly   491 STNSNNNTPAATATVTTSYQCVECVEKFDSKELFDIHRSGHANNMKCAI--CNMVL---KSLKNY 550
            ..:.:...|.........|                         ::|.:  |..||   :.|:::
Human   292 KDDKSPRLPKRRKKPPIQY-------------------------VRCEMEGCGTVLAHPRYLQHH 331

  Fly   551 EK--HCLRCKPYEC--QICGRVVRFRPNFIKHMRVHTGQQSERHKYKCEVCHKEFMSFEYFKVHK 611
            .|  |.|: |.|.|  ..|||:.|.:...::|.:.||.|:.    |.||.|.:.|.|.....||:
Human   332 IKYQHLLK-KKYVCPHPSCGRLFRLQKQLLRHAKHHTDQRD----YICEYCARAFKSSHNLAVHR 391

  Fly   612 KIHNENVNLTCEICGKVFSALASLRGHSKLHSGVKLHKCDVCGKGFGQRYNLKIHARTHTGDFPF 676
            .||.....|.|||||......|||..|.|.|.....::                          |
Human   392 MIHTGEKPLQCEICGFTCRQKASLNWHMKKHDADSFYQ--------------------------F 430

  Fly   677 ECKICKKKLHTQSSLQTHMQVHLRDQPGAAAAAATAAGAASSKASNSSNSSNSSNSSSSNSSSNG 741
            .|.||.||...:.|:..|   ..:..|....|.|.||.|.   |..:|.....:|..|....|:|
Human   431 SCNICGKKFEKKDSVVAH---KAKSHPEVLIAEALAANAG---ALITSTDILGTNPESLTQPSDG 489

  Fly   742 VSAAVSAATTTTTIVKLEPPHEIERPGTSSNQQLQQSQHHQMELDDQSGLSGDEE-----DG--- 798
            ..            :.|.|    |..|.|::.:....:...|   .:|..||.|.     ||
Human   490 QG------------LPLLP----EPLGNSTSGECLLLEAEGM---SKSYCSGTERVSLMADGKIF 535

  Fly   799 -----SGG--GMNSSSHIVNATTNRLTTGEDSS 824
                 |||  |:..:|.|:.|||..|....||:
Human   536 VGSGSSGGTEGLVMNSDILGATTEVLIEDSDSA 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32767	NP_001162674.1	C2H2 Zn finger	537..557	CDD:275368	8/26 (31%)
		C2H2 Zn finger	562..582	CDD:275368	6/21 (29%)
		C2H2 Zn finger	594..614	CDD:275368	7/19 (37%)
		C2H2 Zn finger	622..642	CDD:275368	10/19 (53%)
		zf-C2H2	648..670	CDD:278523	0/21 (0%)
		C2H2 Zn finger	650..670	CDD:275368	0/19 (0%)
		zf-H2C2_2	662..684	CDD:290200	4/21 (19%)
		C2H2 Zn finger	678..698	CDD:275368	7/19 (37%)
ZFP91	NP_444251.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..306		58/403 (14%)
		Interaction with MAP3K14/NIK. /evidence=ECO:0000269\|PubMed:20682767	338..368		10/30 (33%)
		C2H2 Zn finger	347..366	CDD:275368	5/18 (28%)
		C2H2 Zn finger	374..394	CDD:275368	7/19 (37%)
		zf-C2H2	401..422	CDD:333835	10/20 (50%)
		C2H2 Zn finger	402..422	CDD:275368	10/19 (53%)
		C2H2 Zn finger	432..448	CDD:275368	6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	107	1.000	Inparanoid score	I4933
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050