DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32767 and Zfp687

DIOPT Version :9

Sequence 1:	NP_001162674.1	Gene:	CG32767 / 31430	FlyBaseID:	FBgn0052767	Length:	1281	Species:	Drosophila melanogaster
Sequence 2:	NP_001344792.1	Gene:	Zfp687 / 78266	MGIID:	1925516	Length:	1237	Species:	Mus musculus

Alignment Length:	1057	Identity:	207/1057 - (19%)
Similarity:	328/1057 - (31%)	Gaps:	326/1057 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 LQQQQQQQQHHHPHHHLKLDNSSNNHPPTAAAAAAAVAVAATTAATAAAATNNSASFSSNSSSSN 157
            |.|...:|:...|||...|........|..|...|:|:.....          ..||
Mouse   217 LPQGALKQESCSPHHSQGLTQRGPGSSPETAGIPASVSPPQVA----------GVSF-------- 263

  Fly   158 SNNSNHLDNQQQLLIQQQQQQQQHHLLNGRRIIIQATGNSSVLAAS--DIKEEDEEEEDPELNDE 220
                               :|...|         |:...|.|.|.|  .:|||||...| :....
Mouse   264 -------------------KQSPGH---------QSPPASPVKAPSCKPLKEEDEGTVD-KSPPR 299

  Fly   221 NLQDIEEEAQAAEADEEPETTAHLSTQ-VKLELE-----------EDDEMPDEEEEEDEDDDEEL 273
            :.|.....|:||:.|.....|:..|:: :|:.::           ....:|.|     .|....|
Mouse   300 SPQSPSSGAEAADEDSNDSPTSSSSSRPLKVRIKTIKTSCGNITRTVTRVPSE-----PDPPAPL 359

  Fly   274 QHGQ----------------------LEYQISAATQTAG-----AATSSAAGGAATAGGGSQQLV 311
            ..|.                      :..|:...|:..|     |...:|:.....|...:::.|
Mouse   360 AEGAFLAETSFLKLSPVTPTPEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVARKAV 424

  Fly   312 QLPAGSIVSTTTHRLSV----------------------PVTEAALVQLQRRPVYISNAVGGLTA 354
            .||.|:..|..|...||                      .|..|::|.:|..    .:|.|..||
Mouse   425 VLPGGNATSPKTMTKSVLGLVPQTLPKAEVRTGFSLGGQKVNGASVVMVQPS----KSATGPGTA 485

  Fly   355 GATYVRMPAAAVISRSPMTVLNVVQQALPATQLILQTQQQQTPAAAAAEQQLALALEQQRQQQEQ 419
            |        .:||||:..:::....:.|.:..|:...:...:|.|.|.   |||.....|..:..
Mouse   486 G--------GSVISRTQSSLVEAFNKILNSKNLLPAYRPNLSPPAEAG---LALPPTGYRCLECG 539

  Fly   420 QAQQQRQQQQQQEQQRQQQ-----------------------QQQQQQQQQQAQQEQQRQQQQQL 461
            .|....:...:...:|..:                       .::.:.:....|......:...|
Mouse   540 DAFSLEKSLARHYDRRSMRIEVTCNHCARRLVFFNKCSLLLHAREHKDKGLVMQCSHLVMRPVAL 604

  Fly   462 QQQQQQQQTHPVKHSA--------------SGSSS-TNNNSTTNSTNS-----NNNTPA-ATATV 505
            .|...|....|:...|              .|..: |::..||.:|.:     ....|| .||:|
Mouse   605 DQMVGQPDITPLLPVAVPPVPGPLALPVLGKGEGAVTSSTITTVATEAPVLPLPTEPPAPPTASV 669

  Fly   506 TTSYQCVECVEKFDSKELFDIH-------RSGHANNMKCAICNMVLKSLKNYEKHCLRCK---PY 560
            .|.::|:||.|:...|.....|       ..|..:|: |..|.|:|.:..::..|....|   |:
Mouse   670 YTCFRCLECKEQCRDKAGMAAHFQQLGPPALGSTSNV-CPSCPMMLPNRCSFSAHQRTHKNRAPH 733

  Fly   561 ECQICGRVVRFRPNFIKHMRVHTGQQSERHKYKCEVCHKEFMSFEYFKVHKKIHNENVNLTCEIC 625
            .|..||... .:.||..|:|......|.|..|:|..|...|......|.|.:..:..|...|.||
Mouse   734 VCPECGGNF-LQANFQTHLREACLHFSRRVGYRCPSCAVVFGGVNSIKSHIQASHCEVFHKCPIC 797

  Fly   626 GKVFSALASLRGH------SKLHSGVKL-HKCDVCGKGFGQRYNLKIHARTHTGDFP-----FEC 678
            ...|.:..|...|      |.|....|| :||.:|...|..:..|..|...|.  .|     |:|
Mouse   798 PMAFKSAPSAHAHLYSQHPSFLTQQAKLIYKCAMCDTVFTHKPLLSSHFDQHL--LPQRVSVFKC 860

  Fly   679 KICKKKLHTQSSLQTHMQ-VHLRDQPGAAAAAATAAGA-----------ASSKASNSSNSSNSSN 731
            ..|......:.::..|:: .|...:.|..|....|.||           |.|:|..:..:..||:
Mouse   861 PSCPLLFAQKRTMLEHLKNTHQSGRVGEEAVGKGAGGALLTPKTEPEELAVSQAEAAPATEESSS 925

  Fly   732 SSSSNSSSNGVSAAVSAATTTTTIVKLEPPHEIERP--GTSSNQQLQQSQHHQMELDDQSGLSGD 794
            ||.....|:.                 |||...:|.  |...|:.::
Mouse   926 SSEEELPSSP-----------------EPPRPTKRARRGELGNKGIK------------------ 955

  Fly   795 EEDGSGGGMNSSSHIVNATTNRLTTGEDSS---ESSNASLHLNQHSSTS--------------SS 842
               |.|||...           .|.|...|   |......|:.:....|              |:
Mouse   956 ---GGGGGPGG-----------WTCGLCHSWCPERDEYVTHMKKEHGKSVKKFPCRLCERSFCSA 1006

  Fly   843 PASQHQVSSHQQHVHQQQQQQQQSQQQYLVSAPTRTIVIKNYMQQGSQQQQQQQQQQQHTSDPTP 907
            |:.:..|..:.:.:          ::.|    |.|      |..:|.:....:...::|..
Mouse  1007 PSLRRHVRVNHEGI----------KRVY----PCR------YCTEGKRTFSSRLILEKHVQ---- 1047

  Fly   908 VLHAQVI---QSGAGTS--NGSG------------NTSSTNSSSNSSTNIVTTNAGGNLSNGSQL 955
            |.|...:   .||.|.|  .|||            ::.|.:...:|:|....:..||..|.|
Mouse  1048 VRHGLPLGTQSSGRGGSLARGSGGRAQGPGRKRRQSSDSCSEEPDSTTPPAKSLRGGPGSGG--- 1109

  Fly   956 IRKTPIIHHSTGSSNGS 972
              ..|:.:.|:||:..|
Mouse  1110 --HGPLRYRSSGSAEQS 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32767	NP_001162674.1	C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	562..582	CDD:275368	7/19 (37%)
		C2H2 Zn finger	594..614	CDD:275368	5/19 (26%)
		C2H2 Zn finger	622..642	CDD:275368	7/25 (28%)
		zf-C2H2	648..670	CDD:278523	6/21 (29%)
		C2H2 Zn finger	650..670	CDD:275368	5/19 (26%)
		zf-H2C2_2	662..684	CDD:290200	7/26 (27%)
		C2H2 Zn finger	678..698	CDD:275368	3/20 (15%)
Zfp687	NP_001344792.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..151
		PHA03307	30..>281	CDD:223039	19/109 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..331		34/160 (21%)
		PHA03247	<169..532	CDD:223021	74/381 (19%)
		C2H2 Zn finger	707..727	CDD:275368	5/19 (26%)
		C2H2 Zn finger	735..757	CDD:275368	7/22 (32%)
		zf-C2H2_8	795..877	CDD:406359	20/83 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..957		20/115 (17%)
		C2H2 Zn finger	966..986	CDD:275368	4/19 (21%)
		C2H2 Zn finger	996..1017	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1026..1046	CDD:275368	3/25 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1052..1117		15/69 (22%)
		zf-C2H2_11	1131..1159	CDD:406917
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1166..1195
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000