DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32767 and erm

DIOPT Version :9

Sequence 1:	NP_001162674.1	Gene:	CG32767 / 31430	FlyBaseID:	FBgn0052767	Length:	1281	Species:	Drosophila melanogaster
Sequence 2:	NP_001259891.2	Gene:	erm / 326152	FlyBaseID:	FBgn0031375	Length:	698	Species:	Drosophila melanogaster

Alignment Length:	865	Identity:	173/865 - (20%)
Similarity:	301/865 - (34%)	Gaps:	234/865 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 SDIKEEDEEEEDPELNDENLQDIEEEAQAAEADEEPETTAHLSTQVKL---ELEEDDEMP----- 259
            |.:.|....|::|               |.::.::.|.:|..:..:|.   ::.|.|..|
  Fly    26 SPVMESAASEQNP---------------AQQSQQQDEQSAKRACPLKFSIAKIMEPDHRPSQVPP 75

  Fly   260 -----------DEEEEEDEDDDEELQHGQLEYQISAATQTAGAATSSAAGGAATAGGGSQQLVQL 313
                       |::|:||.:.|.:.:......::.:..|:.......:|         .::.|..
  Fly    76 PQPAPVSFATNDDDEDEDPEIDADSERSCSPIEVISLDQSPSTVNYDSA---------FKKYVPG 131

  Fly   314 PAGSIVSTTTHRLSVPVTEAALVQLQRRPVYISNAVGGLTAGATYVRMPAAAVISRSPMTVL--N 376
            |.    |..|..::.|.:.||:.|                    :|......::|:.|:...  |
  Fly   132 PC----SGATSSVASPPSTAAVQQ--------------------FVSSRHQELLSQYPLLYYAPN 172

  Fly   377 VVQQALPATQLILQTQQQQTPAAAAAEQQLALALEQQRQQQEQ-----------QAQQQRQQQQQ 430
            .:..|..|.|....|.|||:.|:||.......:|.......:.           .|......|.|
  Fly   173 QLMCAAAAAQYAALTAQQQSLASAAHLSSFTASLNASLHHSQSLRRNLGHPLAAAAAVAAVAQSQ 237

  Fly   431 QEQQRQQQQQQQQQQQQQAQQE-QQRQQQQQLQQQQQQQQTHPVKHSASGSSSTNNNSTTNSTNS 494
            .....|...::....|:.||.. .|...:::...|.|.:.|.|...:|:.::...:.|.:...:.
  Fly   238 AVPNLQHTLEKSPVAQRTAQSSGLQANLKRKRSPQDQGEVTPPPASTATSATGARSRSPSPQGSI 302

  Fly   495 NNNTP-AATATVTTSYQCVECVEKFDSKELFDIHRSGHANNMKCAICNMVLKSLKNYEKHCLRCK 558
            .:::| :|:.....::.|:||.:.|::......|...|..                       .:
  Fly   303 EDSSPGSASGGKPKTFSCLECGKVFNAHYNLTRHMPVHTG-----------------------AR 344

  Fly   559 PYECQICGRVVRFRPNFIKHMRVHTGQQSERHKYKCEVCHKEFMSFEYFKVHKKIHNENVNLTCE 623
            |:.|::||:..|......:|..:||.::    .:||:.|.|.|........|.:||.......||
  Fly   345 PFVCKVCGKGFRQASTLCRHKIIHTSEK----PHKCQTCGKAFNRSSTLNTHSRIHAGYKPFVCE 405

  Fly   624 ICGKVFSALASLRGHSKLHSGVKLHKCDVCGKGFGQRYNLKIHARTHTGDFPFECKICKKKLHTQ 688
            .|||.|....:.:.|...|||.|.:||::|.|.|.|.|||..|..||....|:.|::|.|.....
  Fly   406 YCGKGFHQKGNYKNHKLTHSGEKAYKCNICNKAFHQVYNLTFHMHTHNDKKPYTCRVCAKGFCRN 470

  Fly   689 SSLQTHMQVHLRDQPGAAAAAATAAGAASSKASNSSNSSNSSNSSSSNSSSNGVSAAVSAATTTT 753
            ..|:.||: .|.:..|
  Fly   471 FDLKKHMR-KLHEIGG------------------------------------------------- 485

  Fly   754 TIVKLEPPHEIERPGTSSNQQLQQSQHHQMELDDQSGLSGD-EEDGSGGGMNSSSHIVNATTNRL 817
            .:..|:.|...:|....:.::...|.:.|        .||. ..|.|.|.|   |..:|.||..|
  Fly   486 DLDDLDMPPTYDRRREYTRREPLASGYGQ--------ASGQLTPDSSSGSM---SPPINVTTPPL 539

  Fly   818 TTGEDSSESSNASLHLNQHSSTSSSPAS--QHQVSSHQQHVHQQQQQQQQSQQQYLVSAPTRTIV 880
            ::||.|:.:.       ..|:.|..|..  .||:.....|.:                 |:.:..
  Fly   540 SSGETSNPAW-------PRSAVSQYPPGGFHHQLGVAPPHDY-----------------PSGSAF 580

  Fly   881 IKNYMQQGSQQQQQQQQQQQHTSDPTPVLHAQVIQS---GAGTSNGSGNTSSTNSSSNSSTNIVT 942
            ::...||...|.||..||||..|:   ...|:|...   ....::.:|:||:|:|:..::|..::
  Fly   581 LQLQPQQPHPQSQQHHQQQQRLSE---TFIAKVFXQRYYAESLNSSTGSTSTTSSTVTTTTTAIS 642

  Fly   943 TNAGGNLSNGSQLIRKTPIIHHSTGSSNGSGGSALTSVVQQTGVISPAQSPSSSSTSCSSSTVLV 1007
            :.|   .|....||.....:..:..:|:.:.|       |.||     :|| |....|::
  Fly   643 SMA---TSRSDLLIDXLQFVAAAAAASSSNSG-------QDTG-----ESP-SPELGCTA----- 686

  Fly  1008 SKATGVPLSIASSAAAALGG 1027
                      ..||..||.|
  Fly   687 ----------LGSAVRALNG 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32767	NP_001162674.1	C2H2 Zn finger	537..557	CDD:275368	0/19 (0%)
		C2H2 Zn finger	562..582	CDD:275368	5/19 (26%)
		C2H2 Zn finger	594..614	CDD:275368	5/19 (26%)
		C2H2 Zn finger	622..642	CDD:275368	7/19 (37%)
		zf-C2H2	648..670	CDD:278523	10/21 (48%)
		C2H2 Zn finger	650..670	CDD:275368	9/19 (47%)
		zf-H2C2_2	662..684	CDD:290200	8/21 (38%)
		C2H2 Zn finger	678..698	CDD:275368	6/19 (32%)
erm	NP_001259891.2	COG5048	<295..461	CDD:227381	49/192 (26%)
		C2H2 Zn finger	320..340	CDD:275368	5/19 (26%)
		zf-H2C2_2	332..357	CDD:290200	6/47 (13%)
		zf-C2H2	346..368	CDD:278523	5/21 (24%)
		C2H2 Zn finger	348..368	CDD:275368	5/19 (26%)
		zf-H2C2_2	363..385	CDD:290200	8/25 (32%)
		C2H2 Zn finger	376..396	CDD:275368	5/19 (26%)
		zf-H2C2_2	389..413	CDD:290200	9/23 (39%)
		C2H2 Zn finger	404..424	CDD:275368	7/19 (37%)
		zf-H2C2_2	416..441	CDD:290200	10/24 (42%)
		C2H2 Zn finger	432..452	CDD:275368	9/19 (47%)
		C2H2 Zn finger	460..478	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100