DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32767 and ZNF485

DIOPT Version :9

Sequence 1:	NP_001162674.1	Gene:	CG32767 / 31430	FlyBaseID:	FBgn0052767	Length:	1281	Species:	Drosophila melanogaster
Sequence 2:	NP_001305069.1	Gene:	ZNF485 / 220992	HGNCID:	23440	Length:	441	Species:	Homo sapiens

Alignment Length:	522	Identity:	112/522 - (21%)
Similarity:	191/522 - (36%)	Gaps:	94/522 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 GGLTAGATYVRMPAAAVISRSPMTVLNVVQQALPATQLILQTQQQQTPAAAAAEQQLALALEQQR 414
            |.||.|      ..|...:|.....|:..|:||....::.......:....:::.:|...|||..
Human     9 GPLTFG------DVAVAFTRIEWRHLDAAQRALYRDVMLENYGNLVSVGLLSSKPKLITQLEQGA 67

  Fly   415 QQQEQQAQQQRQQQQQQEQQRQQQQQQQQQQQQQAQQEQQRQQQQQLQQQQQQQQTHPVKHSASG 479
            :...:..:........::...:.:....:|...:|....:|.:...:::....:          |
Human    68 EPWTEVREAPSGTHAVEDYWFETKMSALKQSTSEASVLGERTKSVMMEKGLDWE----------G 122

  Fly   480 SSSTNNNSTTNSTNSNNNTPAATATVTTSYQCVECVEKFDSKELFDIHRSGHANN-----MKCAI 539
            .|||..|                      |:|.||.:.|.....|..|:..|.:.     .:|.|
Human   123 RSSTEKN----------------------YKCKECGKVFKYNSSFISHQRNHTSEKPHKCKECGI 165

  Fly   540 CNMVLKSLKNYEKHCLRCKPYECQICGRVVRFRPNFIKHMRVHTGQQSERHKYKCEVCHKEFMSF 604
            ..|...||.|:.|.....:||.|..||:.::....||.|.|:|    |....:||..|.|.|...
Human   166 AFMNSSSLLNHHKVHAGKQPYRCIECGKFLKKHSTFINHQRIH----SREKPHKCIECGKTFRKN 226

  Fly   605 EYFKVHKKIHNENVNLTCEICGKVFSALASLRGHSKLHSGVKLHKCDVCGKGFGQRYNLKIHART 669
            .....|::||.......|..|||.|:..|:|..|.::|||.|..||:.||:.|.....:..|.:.
Human   227 SILLSHQRIHTGQKPYKCNDCGKAFAQNAALTRHERIHSGEKPFKCNKCGRAFRDNSTVLEHQKI 291

  Fly   670 HTGDFPFECKICKKKLHTQSSLQTHMQVHLRDQPGAAAAAATAAGAASSKASNSSNSSNSSNSSS 734
            |||:.|::|..|.|.....|:|.:|.::|..::|...:....:...:||.|.:....|.:.....
Human   292 HTGEKPYQCNECGKAFRKSSTLISHQRMHTGEKPYHCSKCGKSFRYSSSFAGHQKTHSGNKPYQC 356

  Fly   735 SNSSSNGVSAAVSAATTTTTIVKLEPPHEIERPGTSSNQQLQQSQHHQMELDDQSGLSGDEEDGS 799
            .:..        .|.|.::|:...:..|..|:|            :|..:              .
Human   357 RDCG--------KAFTKSSTLTGHQRIHTGEKP------------YHCKK--------------C 387

  Fly   800 GGGMNSSSHIVNATTNRLTTGEDSSESSNASLHLNQHSSTSSSPASQHQVSSHQQHVHQQQQQQQ 864
            |.....||.:|.  ..||.|||...:.:...     .:...||...||      :.:|.:::..:
Human   388 GKAFRHSSGLVE--HQRLHTGEKPYKCNECG-----KAFPRSSALKQH------KKIHNKERAMK 439

  Fly   865 QS 866
            .|
Human   440 CS 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32767	NP_001162674.1	C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	562..582	CDD:275368	7/19 (37%)
		C2H2 Zn finger	594..614	CDD:275368	5/19 (26%)
		C2H2 Zn finger	622..642	CDD:275368	8/19 (42%)
		zf-C2H2	648..670	CDD:278523	6/21 (29%)
		C2H2 Zn finger	650..670	CDD:275368	5/19 (26%)
		zf-H2C2_2	662..684	CDD:290200	7/21 (33%)
		C2H2 Zn finger	678..698	CDD:275368	6/19 (32%)
ZNF485	NP_001305069.1	KRAB	11..71	CDD:214630	13/65 (20%)
		KRAB	11..50	CDD:279668	9/44 (20%)
		COG5048	<124..361	CDD:227381	72/270 (27%)
		C2H2 Zn finger	132..152	CDD:275368	6/19 (32%)
		C2H2 Zn finger	160..180	CDD:275368	7/19 (37%)
		C2H2 Zn finger	188..208	CDD:275368	7/19 (37%)
		C2H2 Zn finger	216..236	CDD:275368	5/19 (26%)
		zf-H2C2_2	229..253	CDD:290200	8/23 (35%)
		C2H2 Zn finger	244..264	CDD:275368	8/19 (42%)
		zf-H2C2_2	256..279	CDD:290200	10/22 (45%)
		C2H2 Zn finger	272..292	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..307	CDD:290200	8/19 (42%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		zf-H2C2_2	313..337	CDD:290200	4/23 (17%)
		C2H2 Zn finger	328..348	CDD:275368	3/19 (16%)
		C2H2 Zn finger	356..376	CDD:275368	3/27 (11%)
		zf-H2C2_2	372..393	CDD:290200	5/46 (11%)
		C2H2 Zn finger	384..404	CDD:275368	5/35 (14%)
		zf-H2C2_2	397..419	CDD:290200	6/28 (21%)
		C2H2 Zn finger	412..432	CDD:275368	4/30 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100