DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ovo and ZNF764

DIOPT Version :9

Sequence 1:	NP_001162673.1	Gene:	ovo / 31429	FlyBaseID:	FBgn0003028	Length:	1351	Species:	Drosophila melanogaster
Sequence 2:	NP_219363.2	Gene:	ZNF764 / 92595	HGNCID:	28200	Length:	408	Species:	Homo sapiens

Alignment Length:	190	Identity:	52/190 - (27%)
Similarity:	79/190 - (41%)	Gaps:	42/190 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1172 HGSAEALCMGSSGGANEDSSSGNNKFVCRVCMKTFSLQRLLNRHMKCHSDIKRYLCTFCGKGFND 1236
            |....:||      |:......:.:..|.||.|:|:.:..|..|:..|:..|.:.||.|||||..
Human   156 HRGRPSLC------AHPPVPRADQRHGCYVCGKSFAWRSTLVEHVYSHTGEKPFHCTDCGKGFGH 214

  Fly  1237 TFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCQKVHSVQHQYAYKERRAKMYVCEECGHTT 1301
            ...|.:|...|.|.||::|..|.::||||.:|.||. :||:.:          |.|.|.:||...
Human   215 ASSLSKHRAIHRGERPHRCLECGRAFTQRSALTSHL-RVHTGE----------KPYGCADCGRRF 268

  Fly  1302 CEPEVHYLHLK---NNHPFS----------PALLKFYDKRHFKFTNSQFANNLLGQLPMP 1348
            .:....|.|.:   ...||.          |:.|:.:.:.|            .|:.|.|
Human   269 SQSSALYQHRRVHSGETPFPCPDCGRAFAYPSDLRRHVRTH------------TGEKPYP 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ovo	NP_001162673.1	C2H2 Zn finger	1199..1219	CDD:275368	7/19 (37%)
		zf-H2C2_2	1212..1235	CDD:290200	10/22 (45%)
		C2H2 Zn finger	1227..1247	CDD:275368	9/19 (47%)
		zf-H2C2_2	1239..1264	CDD:290200	9/24 (38%)
		C2H2 Zn finger	1255..1276	CDD:275368	9/20 (45%)
ZNF764	NP_219363.2	zf-H2C2_2	301..326	CDD:290200	5/28 (18%)
		C2H2 Zn finger	317..337	CDD:275368	52/190 (27%)
		zf-H2C2_2	333..352	CDD:290200
		C2H2 Zn finger	345..365	CDD:275368
		KRAB	26..85	CDD:214630
		KRAB	26..65	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..167		4/16 (25%)
		C2H2 Zn finger	177..197	CDD:275368	7/19 (37%)
		zf-H2C2_2	190..212	CDD:290200	9/21 (43%)
		C2H2 Zn finger	205..225	CDD:275368	9/19 (47%)
		zf-H2C2_2	217..242	CDD:290200	9/24 (38%)
		COG5048	229..>294	CDD:227381	22/75 (29%)
		C2H2 Zn finger	233..253	CDD:275368	9/20 (45%)
		zf-H2C2_2	245..270	CDD:290200	10/35 (29%)
		C2H2 Zn finger	261..281	CDD:275368	5/19 (26%)
		zf-H2C2_2	273..298	CDD:290200	4/24 (17%)
		COG5048	285..>350	CDD:227381	8/44 (18%)
		C2H2 Zn finger	289..309	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910