DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ovo and ZNF121

DIOPT Version :9

Sequence 1:NP_001162673.1 Gene:ovo / 31429 FlyBaseID:FBgn0003028 Length:1351 Species:Drosophila melanogaster
Sequence 2:NP_001008727.1 Gene:ZNF121 / 7675 HGNCID:12904 Length:390 Species:Homo sapiens


Alignment Length:341 Identity:79/341 - (23%)
Similarity:131/341 - (38%) Gaps:78/341 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1018 AHLQRPMSSSSSSGGTNSSNSSGGSSNSPLLDANAAAAAAAALLDTKPLIQSLGLPPDLQLEFVN 1082
            ||:     .:.::|.|...:..|  .|.|:|..:|.|....::|:  ...::..|||::......
Human    28 AHM-----GTENTGDTYDCDEYG--ENFPMLHNSAPAGETLSVLN--QCRKAFSLPPNVHQRTWI 83

  Fly  1083 GGHGIK----NPLAVENAHGGHHRIRNIDCIDDLSKHGHHSQHQQQQ---GSPQQQNMQQSVQQQ 1140
            |....:    ....|:.:|...:||          .|...:.::|:|   ......:...||:..
Human    84 GDKSFEYSDCEEAFVDQSHLQANRI----------THNGETLYEQKQCGRAFTYSTSHAVSVKMH 138

  Fly  1141 SVQQQQSLQQ--------QQQQQHHQHHSNS------------SASSNASSH-----GSAEALC- 1179
            :|::....::        .....|.:.|:..            :.||:...|     |.....| 
Human   139 TVEKPYECKECGKFFRYSSYLNSHMRTHTGEKPYECKECGKCFTVSSHLVEHVRIHTGEKPYQCK 203

  Fly  1180 ------MGSSG-GANEDSSSGNNKFVCRVCMKTFSLQRLLNRHMKCHSDIKRYLCTFCGKGFNDT 1237
                  .|.|| ..:....:|...:.|..|.|.::...||..|.|.|::.|.:.|..|||.|..:
Human   204 ECGRAFAGRSGLTKHVRIHTGEKPYECNECGKAYNRFYLLTEHFKTHTEEKPFECKVCGKSFRSS 268

  Fly  1238 FDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCQKVHSVQHQYAYKE---------------- 1286
            ..||.|.|.|||::||||..|.|:||...||.:|. |:|:.:..|..|:                
Human   269 SCLKNHFRIHTGIKPYKCKECGKAFTVSSSLHNHV-KIHTGEKPYECKDCGKAFATSSQLIEHIR 332

  Fly  1287 --RRAKMYVCEECGHT 1300
              ...|.|:|:|||.|
Human   333 THTGEKPYICKECGKT 348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ovoNP_001162673.1 C2H2 Zn finger 1199..1219 CDD:275368 7/19 (37%)
zf-H2C2_2 1212..1235 CDD:290200 9/22 (41%)
C2H2 Zn finger 1227..1247 CDD:275368 9/19 (47%)
zf-H2C2_2 1239..1264 CDD:290200 14/24 (58%)
C2H2 Zn finger 1255..1276 CDD:275368 9/20 (45%)
ZNF121NP_001008727.1 C2H2 Zn finger 65..82 CDD:275368 3/18 (17%)
COG5048 <85..270 CDD:227381 35/194 (18%)
C2H2 Zn finger 91..110 CDD:275368 4/28 (14%)
C2H2 Zn finger 119..138 CDD:275368 3/18 (17%)
zf-C2H2 144..166 CDD:278523 1/21 (5%)
C2H2 Zn finger 146..166 CDD:275368 1/19 (5%)
zf-H2C2_2 158..182 CDD:290200 2/23 (9%)
C2H2 Zn finger 174..194 CDD:275368 3/19 (16%)
zf-H2C2_2 186..210 CDD:290200 3/23 (13%)
C2H2 Zn finger 202..222 CDD:275368 4/19 (21%)
zf-H2C2_2 215..239 CDD:290200 4/23 (17%)
COG5048 <226..388 CDD:227381 43/124 (35%)
C2H2 Zn finger 230..250 CDD:275368 7/19 (37%)
zf-H2C2_2 243..267 CDD:290200 10/23 (43%)
C2H2 Zn finger 258..278 CDD:275368 9/19 (47%)
zf-H2C2_2 271..294 CDD:290200 13/22 (59%)
C2H2 Zn finger 286..306 CDD:275368 9/20 (45%)
zf-H2C2_2 301..323 CDD:290200 5/22 (23%)
C2H2 Zn finger 314..334 CDD:275368 1/19 (5%)
zf-H2C2_2 327..349 CDD:290200 7/22 (32%)
C2H2 Zn finger 342..362 CDD:275368 5/7 (71%)
zf-H2C2_2 354..379 CDD:290200
C2H2 Zn finger 370..390 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.