DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ovo and REST

DIOPT Version :9

Sequence 1:	NP_001162673.1	Gene:	ovo / 31429	FlyBaseID:	FBgn0003028	Length:	1351	Species:	Drosophila melanogaster
Sequence 2:	NP_001180437.1	Gene:	REST / 5978	HGNCID:	9966	Length:	1097	Species:	Homo sapiens

Alignment Length:	459	Identity:	96/459 - (20%)
Similarity:	144/459 - (31%)	Gaps:	145/459 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   989 HDNSNMSLPSPTAAAAAAAAAAAAAAAAAAHL----QRPMSSSSSSGGTNSSNSSGGSSNSPLLD 1049
            ||.|...|.:|.....|..|.......:....    :|.|:.....|..|.|:|..|..    |:
Human    34 HDLSKAELAAPQLIMLANVALTGEVNGSCCDYLVGEERQMAELMPVGDNNFSDSEEGEG----LE 94

  Fly  1050 ANAAAAAAAALLDTKPLIQSLGLPPDLQLEFVNGGHGIKN------------PLAVENAHGGHHR 1102
            .:|         |.|      |.|           ||::|            |..|..|.|.
Human    95 ESA---------DIK------GEP-----------HGLENMELRSLELSVVEPQPVFEASGA--- 130

  Fly  1103 IRNIDCIDDLSKHGHHSQHQQQQGSPQQQNMQQSVQQQSVQ----QQQSLQQQQQQQHHQHHSNS 1163
                   .|:    :.|.......:|..::..:|.:.:..:    |.::..::|...|.:.||..
Human   131 -------PDI----YSSNKDLPPETPGAEDKGKSSKTKPFRCKPCQYEAESEEQFVHHIRVHSAK 184

  Fly  1164 SASSNASSHGSAEALCMGSSGGANEDSS----------------------------SGNNK--FV 1198
            ......|:...|:|...|||.....|.|                            :|:|:  :.
Human   185 KFFVEESAEKQAKARESGSSTAEEGDFSKGPIRCDRCGYNTNRYDHYTAHLKHHTRAGDNERVYK 249

  Fly  1199 CRVCMKTFSLQRLLNRHMKCHSDIKRYLCTFCGKGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFT 1263
            |.:|..|...:....:|::.|...|.|.|..|....:...:..:|.|||||.|||||.||..|.:
Human   250 CIICTYTTVSEYHWRKHLRNHFPRKVYTCGKCNYFSDRKNNYVQHVRTHTGERPYKCELCPYSSS 314

  Fly  1264 QRCSLESH--------------CQKVHSVQHQYAYKERRA----KMYVCEECGHTTCE------- 1303
            |:..|..|              |..|.|.||:.....|:.    |...|..|.:.|.:
Human   315 QKTHLTRHMRTHSGEKPFKCDQCSYVASNQHEVTRHARQVHNGPKPLNCPHCDYKTADRSNFKKH 379

  Fly  1304 PEVH---------------------YLHLKNNHPFSPALLKFYDKRHFKFTNSQFANNLLGQLPM 1347
            .|:|                     ..|.|:.||..|.......|...|.|..:.|:     ||.
Human   380 VELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPTCPNKTMDVSKVKLKKTKKREAD-----LPD 439

  Fly  1348 PVHN 1351
            .:.|
Human   440 NITN 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ovo	NP_001162673.1	C2H2 Zn finger	1199..1219	CDD:275368	4/19 (21%)
		zf-H2C2_2	1212..1235	CDD:290200	6/22 (27%)
		C2H2 Zn finger	1227..1247	CDD:275368	4/19 (21%)
		zf-H2C2_2	1239..1264	CDD:290200	14/24 (58%)
		C2H2 Zn finger	1255..1276	CDD:275368	8/34 (24%)
REST	NP_001180437.1	Interaction with SIN3A. /evidence=ECO:0000269\|PubMed:10734093	32..122		23/117 (20%)
		Interaction with SIN3B. /evidence=ECO:0000269\|PubMed:16288918	43..57		3/13 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..103		9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..159		6/45 (13%)
		Interaction with ZFP90. /evidence=ECO:0000269\|PubMed:21284946	145..418		60/272 (22%)
		Required for binding to the neuron-restrictive silencer element. /evidence=ECO:0000250\|UniProtKB:Q8VIG1	201..212		4/10 (40%)
		C2H2 Zn finger	250..270	CDD:275368	4/19 (21%)
		C2H2 Zn finger	278..298	CDD:275368	4/19 (21%)
		COG5048	302..>381	CDD:227381	21/78 (27%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		zf-H2C2_2	318..343	CDD:316026	4/24 (17%)
		C2H2 Zn finger	334..355	CDD:275368	6/20 (30%)
		C2H2 Zn finger	363..383	CDD:275368	4/19 (21%)
		C2H2 Zn finger	391..407	CDD:275368	0/15 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..642
		FtsK	<599..>767	CDD:332908
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	774..837
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	853..938
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	961..1049
		Interaction with RCOR1. /evidence=ECO:0000269\|PubMed:10449787	1009..1087
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910