DRSC/TRiP Functional Genomics Resources

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Protein Alignment ovo and ZNF253

DIOPT Version :9

Sequence 1:NP_001162673.1 Gene:ovo / 31429 FlyBaseID:FBgn0003028 Length:1351 Species:Drosophila melanogaster
Sequence 2:NP_066385.2 Gene:ZNF253 / 56242 HGNCID:13497 Length:499 Species:Homo sapiens


Alignment Length:277 Identity:73/277 - (26%)
Similarity:106/277 - (38%) Gaps:63/277 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1074 PDLQLEFVNGGHGIKNPLAVENAHGGHHRIRNIDCIDDLSKHGHHSQHQQQQGSPQQQNMQQSVQ 1138
            |||......|    |.||.:|     .|.:        ::|....|.|..|...|  :|:|.|.|
Human    50 PDLVTCLEQG----KKPLTME-----RHEM--------IAKPPVMSSHFAQDLWP--ENIQNSFQ 95

  Fly  1139 QQSVQQQQSLQQQQQQ---------QHHQHHSNSSASSNASSHGSAEALCMGSSGGANEDSSSGN 1194
            ...:::.:..:....|         :|..|....:..:...:....|.......|......|:.|
Human    96 IGMLRRYEECRHDNLQLKKGCKSVGEHKVHKGGYNGLNQCLTTTQKEIFQCDKYGKVFHKFSNSN 160

  Fly  1195 ---------NKFVCRVCMKTFSLQRLLNRHMKCHSDIKRYLCTFCGKGFNDTFDLKRHTRTHTGV 1250
                     |.|.|.:|.|.|.....|..|.|.|:..|.|.|..|||.||.:.:|..|.|.|||.
Human   161 TYKTRHTGINLFKCIICGKAFKRSSTLTTHKKIHTGEKPYRCEECGKAFNQSANLTTHKRIHTGE 225

  Fly  1251 RPYKCNLCEKSFTQRCSLESHCQKVHSVQHQYAYKE-----RRA-------------KMYVCEEC 1297
            :||:|..|.|:|.|..:|.:| :|:|:.:..|..:|     .|:             |.|.||||
Human   226 KPYRCEECGKAFKQSSNLTTH-KKIHTGEKPYKCEECGKAFNRSTDLTTHKIVHTGEKPYKCEEC 289

  Fly  1298 G-------HTTCEPEVH 1307
            |       |.|...::|
Human   290 GKAFKHPSHVTTHKKIH 306

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ovoNP_001162673.1 C2H2 Zn finger 1199..1219 CDD:275368 7/19 (37%)
zf-H2C2_2 1212..1235 CDD:290200 10/22 (45%)
C2H2 Zn finger 1227..1247 CDD:275368 9/19 (47%)
zf-H2C2_2 1239..1264 CDD:290200 12/24 (50%)
C2H2 Zn finger 1255..1276 CDD:275368 8/20 (40%)
ZNF253NP_066385.2 KRAB 4..62 CDD:214630 5/15 (33%)
KRAB 6..43 CDD:279668
C2H2 Zn finger 146..166 CDD:275368 3/19 (16%)
COG5048 170..>497 CDD:227381 48/138 (35%)
C2H2 Zn finger 174..194 CDD:275368 7/19 (37%)
zf-H2C2_2 187..211 CDD:290200 11/23 (48%)
C2H2 Zn finger 202..222 CDD:275368 9/19 (47%)
zf-H2C2_2 214..239 CDD:290200 12/24 (50%)
C2H2 Zn finger 230..250 CDD:275368 8/20 (40%)
zf-H2C2_2 242..267 CDD:290200 6/25 (24%)
C2H2 Zn finger 258..278 CDD:275368 2/19 (11%)
zf-H2C2_2 270..295 CDD:290200 7/24 (29%)
C2H2 Zn finger 286..306 CDD:275368 7/19 (37%)
C2H2 Zn finger 314..334 CDD:275368
zf-H2C2_2 326..350 CDD:290200
C2H2 Zn finger 342..362 CDD:275368
zf-H2C2_2 354..379 CDD:290200
C2H2 Zn finger 370..390 CDD:275368
zf-H2C2_2 383..406 CDD:290200
C2H2 Zn finger 398..418 CDD:275368
zf-H2C2_2 411..434 CDD:290200
C2H2 Zn finger 426..446 CDD:275368
zf-H2C2_2 439..462 CDD:290200
C2H2 Zn finger 454..474 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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