DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ovo and FEZF2

DIOPT Version :9

Sequence 1:	NP_001162673.1	Gene:	ovo / 31429	FlyBaseID:	FBgn0003028	Length:	1351	Species:	Drosophila melanogaster
Sequence 2:	NP_060478.3	Gene:	FEZF2 / 55079	HGNCID:	13506	Length:	459	Species:	Homo sapiens

Alignment Length:	352	Identity:	82/352 - (23%)
Similarity:	128/352 - (36%)	Gaps:	106/352 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1025 SSSSSSGGTNSSNSSGGSSNSPLLDANA------------------AAAAAAALLDTKPLIQSLG 1071
            |..:..||.......||...:|:..|:.                  :|..|..::..:.:.|::|
Human    98 SLRAGGGGGGGGGGGGGGGGAPVCGASGLCKTNCGVCCKAELGLAPSALPAGRVIKPQVINQAVG 162

  Fly  1072 LPPDLQLEFVN-------------GGH----GIKN---PLAVENAHGGHHRIRNIDCID---DLS 1113
            ||....|.:.|             .||    |:.|   |.|:. ||.....:.|.....   |..
Human   163 LPASGSLYYFNYLDSTAYPPSELLSGHLFPSGLLNAQAPAALA-AHPKLFLLENAKLAGLAADKF 226

  Fly  1114 KHGHHSQHQQQQGSPQQQNMQQSVQQQSVQQQQSLQQQQQQQHHQHHSNSSASSNASSHGSAEAL 1178
            .|.....|:::..:|.:|.:::                          ||:.::..........|
Human   227 PHPAPYPHKERLPAPLEQVLKE--------------------------NSALTAERGGVKGHSKL 265

  Fly  1179 CMGSSGGANEDSSSGNNKFVCRVCMKTFSLQRLLNRHMKCHSDIKRYLCTFCGKGFNDTFDLKRH 1243
            ..||:.|..::       |.|.||.|.|:....|.|||..|:..:.::|..|||||.....|.||
Human   266 PGGSADGKPKN-------FTCEVCGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLCRH 323

  Fly  1244 TRTHTGVRPYKCNLCEKSFTQRCSLESHCQKVHSVQHQYAYKERRAKMYVCEECGHTTCEPEVHY 1308
            ...||..:|:|||.|.|:|.:..:|.:|. ::|:     .||.     :|||.||..
Human   324 KIIHTQEKPHKCNQCGKAFNRSSTLNTHI-RIHA-----GYKP-----FVCEFCGKG-------- 369

  Fly  1309 LHLKNNHPFSPALLKFYDKRHFKFTNS 1335
            .|.|.|:           |.| |.|:|
Human   370 FHQKGNY-----------KNH-KLTHS 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ovo	NP_001162673.1	C2H2 Zn finger	1199..1219	CDD:275368	9/19 (47%)
		zf-H2C2_2	1212..1235	CDD:290200	10/22 (45%)
		C2H2 Zn finger	1227..1247	CDD:275368	9/19 (47%)
		zf-H2C2_2	1239..1264	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1255..1276	CDD:275368	7/20 (35%)
FEZF2	NP_060478.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Engrailed homology 1 repressor. /evidence=ECO:0000250	27..42
		C2H2 Zn finger	279..299	CDD:275368	9/19 (47%)
		COG5048	<289..>395	CDD:227381	41/127 (32%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	7/20 (35%)
		C2H2 Zn finger	363..383	CDD:275368	10/39 (26%)
		SFP1	<385..441	CDD:227516	82/352 (23%)
		C2H2 Zn finger	391..411	CDD:275368
		C2H2 Zn finger	419..437	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910