DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ovo and Prdm9

DIOPT Version :9

Sequence 1:	NP_001162673.1	Gene:	ovo / 31429	FlyBaseID:	FBgn0003028	Length:	1351	Species:	Drosophila melanogaster
Sequence 2:	XP_036016343.1	Gene:	Prdm9 / 213389	MGIID:	2384854	Length:	854	Species:	Mus musculus

Alignment Length:	242	Identity:	65/242 - (26%)
Similarity:	104/242 - (42%)	Gaps:	36/242 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1108 CIDDLSKHGHHSQHQQQQGSPQQQNMQQSVQQQSVQQQQSLQQQQQQQHHQ------------HH 1160
            |.|.|.:....||::..:.|.:.:...:..|:.|.....:|::|.:.:..:            :.
Mouse   442 CSDQLQEQHVDSQNKNDKASNEVKRKSKPRQRISTTFPSTLKEQMRSEESKRTVEELRTGQTTNT 506

  Fly  1161 SNSSASSNASSHGSAEALC---MGSSGGANE--DSSSGNNKFVCRVCMKTFSLQRLLNRHMKCHS 1220
            .::..|..||...|.|..|   .......||  .:.:|...:|||.|.:.|:....|.:|.:.|:
Mouse   507 EDTVKSFIASEISSIERQCGQYFSDKSNVNEHQKTHTGEKPYVCRECGRGFTQNSHLIQHQRTHT 571

  Fly  1221 DIKRYLCTFCGKGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCQKVHSVQHQYAYK 1285
            ..|.|:|..||:||....||.:|.|||||.:||.|..|.:.|||:..|..| |:.|:.:..|..:
Mouse   572 GEKPYVCRECGRGFTQKSDLIKHQRTHTGEKPYVCRECGRGFTQKSDLIKH-QRTHTGEKPYVCR 635

  Fly  1286 E--------------RRA----KMYVCEECGHTTCEPEVHYLHLKNN 1314
            |              :|.    |.|||.|||....:..|...|.:.:
Mouse   636 ECGRGFTQKSVLIKHQRTHTGEKPYVCRECGRGFTQKSVLIKHQRTH 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ovo	NP_001162673.1	C2H2 Zn finger	1199..1219	CDD:275368	6/19 (32%)
		zf-H2C2_2	1212..1235	CDD:290200	9/22 (41%)
		C2H2 Zn finger	1227..1247	CDD:275368	9/19 (47%)
		zf-H2C2_2	1239..1264	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1255..1276	CDD:275368	8/20 (40%)
Prdm9	XP_036016343.1	SSXRD	186..212	CDD:401460
		PR-SET_PRDM7_9	251..379	CDD:380970
		C2H2 Zn finger	523..542	CDD:275368	3/18 (17%)
		COG5048	546..>851	CDD:227381	46/138 (33%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		C2H2 Zn finger	578..598	CDD:275368	9/19 (47%)
		C2H2 Zn finger	606..626	CDD:275368	8/20 (40%)
		C2H2 Zn finger	634..654	CDD:275368	2/19 (11%)
		C2H2 Zn finger	662..682	CDD:275368	6/19 (32%)
		C2H2 Zn finger	690..710	CDD:275368
		C2H2 Zn finger	718..738	CDD:275368
		C2H2 Zn finger	746..766	CDD:275368
		C2H2 Zn finger	774..794	CDD:275368
		C2H2 Zn finger	802..822	CDD:275368
		C2H2 Zn finger	830..850	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910