DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ovo and lin-48

DIOPT Version :9

Sequence 1:	NP_001162673.1	Gene:	ovo / 31429	FlyBaseID:	FBgn0003028	Length:	1351	Species:	Drosophila melanogaster
Sequence 2:	NP_497759.1	Gene:	lin-48 / 175485	WormBaseID:	WBGene00003033	Length:	280	Species:	Caenorhabditis elegans

Alignment Length:	304	Identity:	132/304 - (43%)
Similarity:	160/304 - (52%)	Gaps:	78/304 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1025 SSSSSSGGTNSSNSSGGSSNSPL----LDANAAAAAAAALLDTKPLIQSLGLPPDLQLEFVNGGH 1085
            ::|.|...||||.....:|...|    ||.:.:..|:......|..|.|..:.|  .:||||||:
Worm    31 NTSISRSSTNSSKPEEKNSKKFLIERFLDDDPSPPASILSPSPKAAIPSPIINP--AVEFVNGGY 93

  Fly  1086 GIKNPLAVENAHGGHHRIRNIDCIDDLSKHGHHSQHQQQQGSPQQQNMQQSVQQQSVQQQQSLQQ 1150
            |:|||||                                       .:..|.:..|:.
Worm    94 GVKNPLA---------------------------------------PLISSFETTSIP------- 112

  Fly  1151 QQQQQHHQHHSNSSASSNASSHGSAEALCMGSSGGANEDSSSGNNKFVCRVCMKTFSLQRLLNRH 1215
                     .|..|.||           .:.||....:||      ..|.:|.|.|.||||||||
Worm   113 ---------CSTVSPSS-----------LISSSKDEFQDS------LTCHICGKKFGLQRLLNRH 151

  Fly  1216 MKCHSDIKRYLCTFCGKGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESHCQKVHSVQH 1280
            :|||||:|||||||||||||||||||||||||||||||||..||||||||||||||.:|||.|.|
Worm   152 IKCHSDLKRYLCTFCGKGFNDTFDLKRHTRTHTGVRPYKCEQCEKSFTQRCSLESHLRKVHGVTH 216

  Fly  1281 QYAYKERRAKMYVCEECGHTTCEPEVHYLHLKNNHPFSPALLKF 1324
            ||||||||:|::|||:||:|..:.||:..|:|..||||.|.|:|
Worm   217 QYAYKERRSKVFVCEDCGYTDEKFEVYLSHIKVVHPFSAAYLRF 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ovo	NP_001162673.1	C2H2 Zn finger	1199..1219	CDD:275368	13/19 (68%)
		zf-H2C2_2	1212..1235	CDD:290200	20/22 (91%)
		C2H2 Zn finger	1227..1247	CDD:275368	19/19 (100%)
		zf-H2C2_2	1239..1264	CDD:290200	22/24 (92%)
		C2H2 Zn finger	1255..1276	CDD:275368	16/20 (80%)
lin-48	NP_497759.1	C2H2 Zn finger	135..155	CDD:275368	13/19 (68%)
		C2H2 Zn finger	163..183	CDD:275368	19/19 (100%)
		zf-H2C2_2	175..200	CDD:290200	22/24 (92%)
		C2H2 Zn finger	191..209	CDD:275368	15/17 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3576
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2044
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001339
OrthoInspector	1	1.000	-	-		oto18131
orthoMCL	1	0.900	-	-		OOG6_105449
Panther	1	1.100	-	-	LDO	PTHR10032
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3205
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790