DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ovo and AgaP_AGAP007389

DIOPT Version :9

Sequence 1:	NP_001162673.1	Gene:	ovo / 31429	FlyBaseID:	FBgn0003028	Length:	1351	Species:	Drosophila melanogaster
Sequence 2:	XP_308443.4	Gene:	AgaP_AGAP007389 / 1269793	VectorBaseID:	AGAP007389	Length:	789	Species:	Anopheles gambiae

Alignment Length:	652	Identity:	154/652 - (23%)
Similarity:	227/652 - (34%)	Gaps:	174/652 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   790 ELVSTPSLTPDSVTPVEQHNTNTTQLDV------LHENLLTQLT--HNIVRGGSNQQQQHHQQHG 846
            |...||.||..|.:.||     |..:.|      ..:.:|..|.  ..:....|:...|.|..:|
Mosquito    38 EFYHTPFLTAGSGSNVE-----TAAIVVGAPALAQSQKMLNSLASPSGLASSSSSSTSQQHATNG 97

  Fly   847 VQQQQQQQHSVQQQQQHNVQQ------QHGVQQQHVQQQPPPSYQHATRGLMMQQQPQHGGYQQQ 905
            ....|...:||...||:..|.      ...:..||::       .|...|.:..::.. |.|.||
Mosquito    98 AAPSQTVPNSVSAAQQYQCQLCQKCFISSALLVQHMK-------THDNNGFIAGRETA-GSYGQQ 154

  Fly   906 AAIMSQQQQQLLSQQQQQSHHQQQQQQQHAAAYQQH------------NIYAQQQQQQQQQH--H 956
                .|||||.:|.............:.......||            |.||....:|.:.|  |
Mosquito   155 ----QQQQQQSVSSASSPVTAVASSSKTSPPVATQHIIKSEYIGGTVTNQYAYGMAKQFECHICH 215

  Fly   957 QQQQQQQHHHFH---HQQQQQPQPQSH-----------------HSHHHGHGHDNSNMSLPSPTA 1001
            :......:.:.|   |:...:|...:|                 ..:||| |..:|.:|......
Mosquito   216 KSFMTMVNLNLHMKIHESAIKPLAATHMYAGQAGLAGNLIAGSTAGYHHG-GQHHSQLSQHLAVQ 279

  Fly  1002 AAAAAA--------AAAAAAAAAAAHLQRPMSSSSSSGGTNSSNSSGGSSNSPLLDANAAAAAAA 1058
            :|:.:|        ...:.|...|||::...:...:....:|.:::.|...:|...:|.|.....
Mosquito   280 SASGSADGLCQICHKTFSTADQFAAHMKIHENEFKNRALYHSGSANDGGEGAPAPTSNGAGVGDH 344

  Fly  1059 ALLDTKPLIQSLG-LPPDLQLEFVNGGHGIKNPLAVENAHGGHHRIRNIDCIDDLSKHGHHSQHQ 1122
            ....::|....|| .||.|.   .:.||  :.|:.        |::.| :.|:      |..||:
Mosquito   345 FYTASQPPHHHLGHAPPHLD---ASKGH--RCPIC--------HKMSN-NIIE------HIKQHE 389

  Fly  1123 -QQQGSPQQQNMQQSVQQQSVQQQQSLQQQQQQQHHQHHSNSSASSNASSHGSAEALCMGSSGGA 1186
             |.||:.....                     ..:|..:.:|.:|....|.|       |..|||
Mosquito   390 GQLQGTSDGSG---------------------AGYHPTNDDSQSSLEEDSDG-------GGGGGA 426

  Fly  1187 NED---------------SSSGN-----------NKFVCRVCMKTFSLQRLLNRHMKCHSDIKRY 1225
            ..|               |||||           ..|.|.||.|.|.....|..|||.|:..|.|
Mosquito   427 GGDENLRKHECLICHKKFSSSGNLAIHIREHSGEKPFRCSVCGKGFIQSNNLATHMKTHTGEKPY 491

  Fly  1226 LCTFCGKGFNDTFDLKRHTRTHTGVRPYKCNLCEKSFTQRCSLESH----------C--QKVHSV 1278
            .||.|||.|:.:.:||.|.|||||.:||.|.:|.|.|.|:.:|.:|          |  |.:|.:
Mosquito   492 ACTICGKNFSQSNNLKTHIRTHTGEKPYACTICGKRFNQKNNLTTHMRTHQLVCMVCGVQFMHPI 556

  Fly  1279 Q---HQYAYKERRAKMYVCEECGHTTCEPEVHYLHLKNNH-PFSPALLKFYDKRHFKFTNSQFAN 1339
            .   |...:.:.  |.|:|..|.......:....|:|..| ...|......||   .||.|   |
Mosquito   557 DLATHMKFHNDE--KPYICSVCNKVYLNLDELTEHMKKTHNQVKPYRCHICDK---TFTQS---N 613

  Fly  1340 NL 1341
            ||
Mosquito   614 NL 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ovo	NP_001162673.1	C2H2 Zn finger	1199..1219	CDD:275368	9/19 (47%)
		zf-H2C2_2	1212..1235	CDD:290200	12/22 (55%)
		C2H2 Zn finger	1227..1247	CDD:275368	10/19 (53%)
		zf-H2C2_2	1239..1264	CDD:290200	14/24 (58%)
		C2H2 Zn finger	1255..1276	CDD:275368	9/32 (28%)
AgaP_AGAP007389	XP_308443.4	C2H2 Zn finger	116..136	CDD:275368	3/26 (12%)
		COG5048	207..674	CDD:227381	113/466 (24%)
		C2H2 Zn finger	211..231	CDD:275368	3/19 (16%)
		C2H2 Zn finger	289..309	CDD:275368	4/19 (21%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		zf-H2C2_2	449..474	CDD:290200	7/24 (29%)
		C2H2 Zn finger	465..485	CDD:275368	9/19 (47%)
		zf-H2C2_2	477..502	CDD:290200	13/24 (54%)
		C2H2 Zn finger	493..513	CDD:275368	10/19 (53%)
		zf-H2C2_2	505..530	CDD:290200	14/24 (58%)
		C2H2 Zn finger	521..541	CDD:275368	7/19 (37%)
		C2H2 Zn finger	545..562	CDD:275371	3/16 (19%)
		zf-C2H2_2	573..>648	CDD:289522	14/49 (29%)
		C2H2 Zn finger	573..594	CDD:275370	4/20 (20%)
		zf-C2H2	600..622	CDD:278523	8/22 (36%)
		C2H2 Zn finger	602..622	CDD:275368	8/20 (40%)
		C2H2 Zn finger	630..650	CDD:275368
		zf-C2H2	656..678	CDD:278523
		C2H2 Zn finger	658..678	CDD:275368
		zf-H2C2_2	670..695	CDD:290200
		C2H2 Zn finger	686..706	CDD:275368
		zf-H2C2_2	698..723	CDD:290200
		C2H2 Zn finger	714..734	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910