Protein Alignment Ptp4E and epha5

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: XP_001338064.4
• Gene: epha5 / 797595
• -ID: -
• Length: 983
• Species: Danio rerio
• Alignment Length: 762
• Identity: 146/762 - (19%)
• Similarity: 233/762 - (30%)
• Gaps: 264/762 - (34%)

  Fly   902 PISDLKAI-QVAAREITLHWTAPAGEYTDFELQY------LSADEE-----------APQLLQNV 948
            |.:...|| .|....:.|.||||.......:::|      :|.|..           .||  :..
Zfish   326 PSAPRNAISNVNETSVFLEWTAPEDTGGRKDVRYNILCSKISTDSGHYEPCGSHVRFLPQ--RTG 388

  Fly   949 TKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAP---ISASYQTLTAPPGKV 1010
            .:||.:.:..|..:.||||.|...:|           ||.|  :..|   :|.:..|..|.|..:
Zfish   389 LRNTSVMVVDLLAHTNYTFEVEAMNG-----------VSDL--TGPPRQYVSLNVTTNQAAPSPI 440

  Fly  1011 DYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAAD---VSSYEFPVNATQGKIDGLV 1072
            ...:........:|..|. ||...:|.|..:.|.....|....   :.|.|     |:..:|||.
Zfish   441 TVVKKGKTTKNSITVSWQ-EPDRPNGIILEYEIKYFEKDQETSYTIIKSKE-----TEVLVDGLK 499

  Fly  1073 PGNHYIFRIQAKSALGYG--AEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISF-------- 1127
            |.:.|||:|:|:::.|||  :.|...:|.|.||....:..|..:.|:.|...|.|:.
Zfish   500 PSSAYIFQIRARTSAGYGGFSRRFEFETSPYLAASSEQGQVPIIAVAVTVGIILIALVTGFLMSG 564

  Fly  1128 -RQGY-------------FSNAH---GMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQ 1175
             |.||             |.|.|   ..||:|              ::..:::|        |.|
Zfish   565 RRCGYSKAKQDPDEEKMHFHNGHIKFPSVRTY--------------IDPHTYED--------PNQ 607

  Fly  1176 AIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDT 1240
            |:..:          ...::....||............|:|.||......|.:...|.:..:|:
Zfish   608 AVHEF----------AKEIDVCCITIERVIGAGEFGEVCSGLLRLPGKREIPVAIKTLKAGYTE- 661

  Fly  1241 VYSSPITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYITP 1305
                                               :.|...:..||.:.:.:.......:|.||.
Zfish   662 -----------------------------------KQRRDFLGEASIMGQFEHPNIIHLKGVITK 691

  Fly  1306 NRPVHVKDFSEHYRIMSAD-----SDFRFS---------------EEFEELKHVGRDQACS---- 1346
            ::||.:  .:|:....|.|     :|.:|:               ....|:.:|.||.|..
Zfish   692 SKPVMI--ITEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIASGMRYLSEMGYVHRDLAARNILV 754

  Fly  1347 FANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQG---PLHST 1408
            .:||.|.             .|.|.|..|.:||               |.....|:|   |:..|
Zfish   755 NSNLVCK-------------VSDFGLSRVLEDD---------------PEAAYTTRGGKIPIRWT 791

  Fly  1409 REE------------FWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIID 1461
            ..|            .|       |..|||               |.|    |.||:...
Zfish   792 APEAIAYRKFTSASDVW-------SYGIVM---------------WEV----MSYGERPY----- 825

  Fly  1462 THYHDWSISEFMVSRNCESR-----------IMRHFHFTTW-------PDF-GVPEPPQSLVRFV 1507
                 |.:|...|.:..|..           .:.|.....|       |.| .:......|:|..
Zfish   826 -----WEMSNQDVIKAVEENYRLPGPMDCPTALYHLMMDCWQKDRNSRPKFEEIVSLLDKLIRNP 885

  Fly  1508 RAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIF 1554
            .:.:.::....|...:....|......|.:::..|:.|....|.::|
Zfish   886 SSLKGLVNPSNRVSNLLVEQGSPEGCVFRSVEEWLEAIKMGRYTELF 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628
		fn3	708..796	CDD:394996
		fn3	902..978	CDD:394996	23/93 (25%)
		fn3	1013..1092	CDD:394996	23/83 (28%)
		PTP_tm	1127..1247	CDD:465889	22/144 (15%)
		R3-PTPc	1358..1579	CDD:350396	39/231 (17%)
epha5	XP_001338064.4	EphR_LBD_A5	28..200	CDD:198451
		FN3	<323..>551	CDD:442628	62/245 (25%)
		FN3	437..527	CDD:238020	25/95 (26%)
		EphA2_TM	543..618	CDD:464211	17/106 (16%)
		PTKc_EphR_A	616..882	CDD:270651	60/367 (16%)
		SAM_superfamily	913..976	CDD:472832	5/20 (25%)