Protein Alignment Ptp4E and fn1

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_001025695.1
• Gene: fn1 / 595087
• XenbaseID: XB-GENE-484447
• Length: 2475
• Species: Xenopus tropicalis
• Alignment Length: 1572
• Identity: 340/1572 - (21%)
• Similarity: 550/1572 - (34%)
• Gaps: 454/1572 - (28%)

  Fly    12 RAHHQQQQIQIQTHGRKRQQL------QKQRHNHHHYYQNSQQQQKHF---------------VW 55
            :.|.:...:....:|:.|.:.      |.|......:||.....:||.               .|
 Frog   529 KRHEEGHMMNCTCYGQGRGRWKCDAIDQCQDTETRQFYQIGDSWEKHLQGVRYQCYCYGKGIGEW 593

  Fly    56 ---------LVVGILTIFLAQHA---NAADLVINVPNASSNANAFYRIDYSPPFGF-PEPNTTIP 107
                     ...|.:.:.:.:.:   |:..:..|.|..|...|  |.:.:.|.... |....|||
 Frog   594 HCQPLSTSPAGTGPVQVIITESSNFPNSHPIQWNAPQPSHIKN--YILRWKPKLKTGPWKQATIP 656

  Fly   108 ASDIGKDIKFSRALPGTEYNFWL---------------YYTNST-HREQLTWTVNITTAPDPP-- 154
            ..  ......|...||..|...|               :.|.|| ||...|.|..  |.|.||
 Frog   657 GH--LNSYTISGLKPGILYEGQLISILQYGNREVTTFDFTTTSTIHRSSQTETGE--TTPLPPLV 717

  Fly   155 -ANLSVQLRSSKSAFITWRPPGSGRYSGFRIRVLGLTDLPFERSYSLEGNETLQLSAKELTPGGS 218
             .:.||...::.|..::| ...|...||||:. ..|::...|:.|....|....:|..:|.||..
 Frog   718 ATSESVTEITASSFLVSW-VSASDTVSGFRVE-YELSEDGDEKRYLELPNTATSVSIPDLLPGRR 780

  Fly   219 YQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLW-QPPFPAGIYTHYRVSITP 282
            |.|..|.:.:..|.....|...||.|:.|....|...::|::|:.| :|..|.   |.|||..:|
 Frog   781 YNVNVYQITEEGEKSLILSTTQTTAPDAPPDHNVENVDDTSILIKWTKPQAPV---TGYRVVYSP 842

  Fly   283 DDAIQSVLYVEREGE------PPGPAQAAFKGLVPGREYNISVQTVSEDETSSVPT--------T 333
                 ||     ||.      |......:...|:||.||||::..| ||...|||.        |
 Frog   843 -----SV-----EGSSTELNLPSTATSVSLTELLPGIEYNITIYAV-EDSLESVPIFIQQGTTGT 896

  Fly   334 ARYLTVPE----RVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLS----TSRRIFNVPRA 390
            .:.:.||.    :::.|       |.....:.|.||:  ||...|:|::.    :.|.:.|:|.:
 Frog   897 PQTVIVPSPTDLQLVEV-------TDIKITIMWNPPQ--SEVSGYRVVVKPVSPSDRDVQNLPVS 952

  Fly   391 ANGDSVYFDYPDI--LEPGRTYEVVVKTIADNVNSWPASGEVTLR---PRPVRSLGGFLDDRSNA 450
            .|      .:.::  |.|||||...|..:.....|.|.:|:.|.:   |..::    |.|...:.
 Frog   953 RN------TFAEVVNLHPGRTYTFEVYAVNRGQESEPLAGDFTTKLDAPSDLQ----FTDVTDST 1007

  Fly   451 LHISWEP--AETGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAV 513
            :.|.|.|  |:.||   |.:|. .||...: |:.|      .|..:.|.:.|:||..|..|.|::
 Frog  1008 VVIIWRPPQAKIGR---YLLSV-GQTRGGQ-PSQF------HINPSATNHKLESLSPGTEYTISL 1061

  Fly   514 QALSKGVASNAS-------------------DITRYT-----------------RPA----AP-- 536
            .|| ||...:||                   ::|..|                 ||:    ||
 Frog  1062 VAL-KGNQQSASTTGVFSTLEPVGSIPPYNTEVTETTIVVTWTPVPRIGFKLDVRPSQGGEAPRE 1125

  Fly   537 LIQELRSI-------------------------------------------------DQGLMLSW 552
            :|.|..||                                                 ...|.:.|
 Frog  1126 VISESGSIVISGLTPGVEYMYSISVLKDGVERDIPITKTVVTPVAPPTNLRLQPSRDSATLTVYW 1190

  Fly   553 RSDVNSRQDRYEVHY----QRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHS 613
            .|.::.....|.:..    .:.|...|..:...:|......|.||..|.|.|:|:.....|.|.|
 Frog  1191 DSSISPGITGYRITTAPTPMQVGNSLEEEVGPTQTYCLFENLSPGVEYNVSVYAVKGEEESSPLS 1255

  Fly   614 YFQAVFPKPPQ--NLTLQTVHTNLVVLHWQAPEGSDFSEY---VVRYRTDASPWQRISGLHENEA 673
              |....:.||  :|....|....:.|.|.....|....|   ||........::...|..:...
 Frog  1256 --QIFLQEIPQLTDLKYDDVTDTSIDLRWTPLNSSTIIGYRITVVAAGESVPIYEEFVGPTDGYY 1318

  Fly   674 RIKDMHYGERYLVQVNT-VSFGVESPHPLELNVTMPPQP---VSNVVPLVDSRNLTLEWPRPDG- 733
            ::..:..|..|.:.|.| :|.|..:|..:..:..:||..   .:||.|  |:..:|  |..|..
 Frog  1319 KVSGLEPGIDYEISVITLISGGESAPTTIVQHTAVPPPTNLRFTNVGP--DTMRVT--WSPPTSI 1379

  Fly   734 HVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYR------FEVQASS--NG 790
            .:..:.:::.|..:.|     :||:| .||..:..:.:.:|.|..:|.      :|.:.||  ||
 Frog  1380 ELSSFLVRYSPVKKPD-----DVTEL-SLSPSTNMVVLSNLLPFTEYLVSVHSVYEERESSALNG 1438

  Fly   791 IRSGTTHLSTRTMPLIQSDVFIANAGHEQGQD------ETITLSYTPTPADSTRFDIYRFSMGDP 849
            :  ..|:|.:.|                 |.|      .:.|:.:....|..|.:.| |:.:...
 Frog  1439 V--AKTYLDSPT-----------------GIDFSEITPNSFTVHWIAPRAPITGYRI-RYQLESG 1483

  Fly   850 TIKDKEKLANDTERKLSFSGLTPGKLYNVTVWTVSGGVASLPVQ-RLYRLHPLPISDLKAIQVAA 913
            ..:.||:....:...::.:.|.||..|.|::...:|...|||:. :...:..:| :||:....:.
 Frog  1484 AGRPKEERVPPSRNSITLTHLIPGSEYIVSIIAFNGQQESLPLSGQQATVSDVP-TDLEVTSSSP 1547

  Fly   914 REITLHWTAPAGEYTDFELQYLSADEEAPQLLQNV--TKNTEITLQGLRPYHNYTFTVVVRSGSI 976
            ..:|:.|.||:.....:.:.:.......|:....|  |.|| .|::||.|..:||.||...:|
 Frog  1548 NTLTISWEAPSVNVRYYRITHSQTGGHGPEKEFTVPGTSNT-ATIRGLNPGVSYTITVYAVTG-- 1609

  Fly   977 QGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQP-----SDVQPGEVTFEWSLEPAEQHG 1036
            :|...|         ||.|::..:.|        |..||     :|:|...:..:||..|    |
 Frog  1610 RGDSPA---------SSKPLTIVHMT--------DVDQPTDMAVTDIQDHSIHVKWSPPP----G 1653

  Fly  1037 PIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPI 1101
            |:..:|:|........:..|.....:.|:..|.||.|...|:..|.::   |...|.|
 Frog  1654 PVTGYRVTSVPKSGQGETFSQVVSPDQTEVTIVGLQPAVEYVVSIYSQ---GENGESE------- 1708

  Fly  1102 LAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGL--EMPSWQD 1164
               |:.|.:||.::                    |....::|     |||.::..|  |:|..|
 Frog  1709 ---PLVETAVTNID--------------------HPKGLTFT-----DVGVDSIRLAWEVPDGQ- 1744

  Fly  1165 VQAYTVWL--PYQAIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIK 1227
            |..|.|..  |.:.::...|          :.|.:..|     .:.|       .||.||.|.:.
 Frog  1745 VTRYRVTYSSPEEGVKELFP----------APEGDDDT-----AELH-------GLRPGTEYTVS 1787

  Fly  1228 IRAFTDE----------------------DKFTDTVYS-----------------------SPIT 1247
            |.|..|:                      .:.|.:.:|                       .|:.
 Frog  1788 IVALHDDMESKPMIGIQSTAIPAPTNLQFSQVTPSGFSLSWHAPTIHLSGYLVRVNPKEKTGPMK 1852

  Fly  1248 TERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALP-EGYIT------- 1304
            ..|....:.|.||:.:::.....|.||.               ::|.|.:.| :|.|:
 Frog  1853 EVRLSPGVTATTVTGLMVATKYEVNVYA---------------LKDTLTSQPLQGLISTLDNVSP 1902

  Fly  1305 PNRPVHVKDFSE 1316
            |.|| .|:|.:|
 Frog  1903 PRRP-RVQDVTE 1913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628	76/274 (28%)
		fn3	247..328	CDD:394996	27/87 (31%)
		FN3	319..>749	CDD:442628	118/557 (21%)
		fn3	708..796	CDD:394996	24/99 (24%)
		fn3	902..978	CDD:394996	21/77 (27%)
		fn3	1013..1092	CDD:394996	20/83 (24%)
		PTP_tm	1127..1247	CDD:465889	28/168 (17%)
		R3-PTPc	1358..1579	CDD:350396
fn1	NP_001025695.1	FN1	50..87	CDD:238018
		FN1	95..138	CDD:214494
		FN1	139..182	CDD:214494
		FN1	184..228	CDD:214494
		fn1	229..268	CDD:459644
		FN1	303..341	CDD:238018
		FN2	349..397	CDD:128373
		FN2	409..457	CDD:128373
		FN1	466..509	CDD:214494
		FN1	518..556	CDD:214494	3/26 (12%)
		fn1	557..595	CDD:459644	6/37 (16%)
		fn3	607..687	CDD:394996	16/83 (19%)
		FN3	<707..1011	CDD:442628	90/340 (26%)
		fn3	993..1073	CDD:394996	28/95 (29%)
		FN3	1067..1626	CDD:442628	119/603 (20%)
		fn3	1354..1433	CDD:394996	20/88 (23%)
		fn3	1445..1525	CDD:394996	17/97 (18%)
		FN3	<1531..2010	CDD:442628	100/485 (21%)
		FN3	1990..2070	CDD:238020
		fn3	2210..2267	CDD:394996
		FN1	2297..2341	CDD:214494
		FN1	2342..2383	CDD:214494
		FN1	2385..2424	CDD:238018