DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp4E and PTPRS

DIOPT Version :9

Sequence 1:NP_001162669.1 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster
Sequence 2:NP_002841.3 Gene:PTPRS / 5802 HGNCID:9681 Length:1948 Species:Homo sapiens


Alignment Length:1843 Identity:425/1843 - (23%)
Similarity:646/1843 - (35%) Gaps:563/1843 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    96 PFGFPEPNTTIPASDIGKDIKFSRALPGTEYNFWLYYTNSTHREQLTWTVNITTA----PDPPAN 156
            |.|||.       .|:|..:|.                     .:.|.|..:..|    |||.  
Human   131 PSGFPN-------IDMGPQLKV---------------------VERTRTATMLCAASGNPDPE-- 165

  Fly   157 LSVQLRSSKSAFITWRP---PGSGRYSGFRIRVLGLTDLPFERSYSLEGNE---TLQLSAKELTP 215
                        |||..   |.....|..||:.|        ||.:.|...   .||:.:.|.|.
Human   166 ------------ITWFKDFLPVDPSASNGRIKQL--------RSETFESTPIRGALQIESSEETD 210

  Fly   216 GGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSI 280
            .|.|:    .|......|.|:|                               ||.:|......:
Human   211 QGKYE----CVATNSAGVRYSS-------------------------------PANLYVRELREV 240

  Fly   281 TPDDAIQSVLYVEREGEPPGPAQAAFKGLVPGREYNISVQTV------------SED-------- 325
            .......|:|.:..|             ::||...||:...|            :||        
Human   241 RRVAPRFSILPMSHE-------------IMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMP 292

  Fly   326 ------ETSSVPTTARY-------LTVPERVLNVTFDE----------AYTTSSSFRVRWE---- 363
                  |.:.|..:|.|       |.|.|.|..:|...          ...|::|..:.|:    
Human   293 VGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNP 357

  Fly   364 PPRTY--------SEFDAYQVM--LSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKTIA 418
            .|.:|        |:...||:.  ::|:|      .:..|          |.|...||:.|..: 
Human   358 DPVSYYVIEYKSKSQDGPYQIKEDITTTR------YSIGG----------LSPNSEYEIWVSAV- 405

  Fly   419 DNVNSWPASGEVTLR---------PRPV--RSLGGFLDDRSNALHISW-EPAE-TGRQDSYRISY 470
            :::...|.|..|..|         ||.|  |.|.      :..:.:.| ||.| .|....||:.|
Human   406 NSIGQGPPSESVVTRTGEQAPASAPRNVQARMLS------ATTMIVQWEEPVEPNGLIRGYRVYY 464

  Fly   471 HEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSK---GVASNASDI-TRYT 531
                 ..|...|.....:..:..:|.. |:.|||....|.:.|.|.:.   |..|:...: |:..
Human   465 -----TMEPEHPVGNWQKHNVDDSLLT-TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG 523

  Fly   532 RPAAP--LIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQR--NGTREERTMATNETSLTIHYLHP 592
            .|..|  |..|.|| :..:.|||.........:||:.::.  :|....||.... ||..:..|.|
Human   524 VPGQPMNLRAEARS-ETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPT-TSYVVEDLKP 586

  Fly   593 GSGYEVKVHAIS-------------HGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAP- 643
            .:.|..::.|.|             ..::|:|.:        |||::...:|.:..:::.|:.| 
Human   587 NTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSA--------PPQDVKCVSVRSTAILVSWRPPP 643

  Fly   644 ---EGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLELNV 705
               .......|.||||                                   ..|.|.|.|.|:| 
Human   644 PETHNGALVGYSVRYR-----------------------------------PLGSEDPEPKEVN- 672

  Fly   706 TMPPQPVSNVVPLVDSRNLTLEW--------------PRPDGHVDFYTLKWWP----TDEEDRVE 752
            .:||.....::..::      :|              |.|:..         |    |||:....
Human   673 GIPPTTTQILLEALE------KWTQYRITTVAHTEVGPGPESS---------PVVVRTDEDVPSA 722

  Fly   753 FKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTH------LSTRTMPLIQSDVF 811
            .....:.|.|::.::|:.....:||||:        ..||....|      ...|..|.|: ||.
Human   723 PPRKVEAEALNATAIRVLWRSPAPGRQH--------GQIRGYQVHYVRMEGAEARGPPRIK-DVM 778

  Fly   812 IANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLY 876
            :|:|..|  .|:|                                    .|.::..:.|.|...|
Human   779 LADAQWE--TDDT------------------------------------AEYEMVITNLQPETAY 805

  Fly   877 NVTV--WTVSG-GVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTD----FELQY 934
            ::||  :|:.| |..|.|...:.:...|....|...|.....:...|..|||...|    :.||:
Human   806 SITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF 870

  Fly   935 LSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISAS 999
            ...|......|:........|..|:.....|.|.:..||....|.:.|:|           :|..
Human   871 GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEV-----------LSIP 924

  Fly  1000 YQTLTAPPGKVDYFQPS-DVQPGEVTFEW-SLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVN 1062
            ..|   |.|.....:.: :...|.|...| ...|||::|.|..:.:..:.|.........|.|..
Human   925 EDT---PRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETELPAA 986

  Fly  1063 ATQG-----KIDGLVPGNHYIFRIQAKSALGYGA----------EREHI-----------QTMPI 1101
            |..|     .:.||.|...|..:::|.:..|.|.          .|:.:           :|..:
Human   987 AEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVL 1051

  Fly  1102 LAPPVPE--PSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQD 1164
            |:...|:  .|.||.::.....|:::..|.......|....::...:..:.|.:..||:    |.
Human  1052 LSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQ----QT 1112

  Fly  1165 VQAYTVW-----LPYQAIEP--------YNP-------------------------FLTSNGS-- 1189
            |.|:|.:     .|..|.:|        |.|                         |||..||  
Human  1113 VTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPE 1177

  Fly  1190 ---------------RKS-----SLE------AEHFTI-------GTANCDKHQAGYCNGPLRAG 1221
                           |:|     .||      |..|::       |.   .|...|:.|..|..|
Human  1178 DMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGD---QKQYGGFDNRGLEPG 1239

  Fly  1222 TTYRIKIRAF--TDEDKFTDTVYSSPITTERSDTV-----------IVAATVSAVLLVAMVLVVV 1273
            ..|.:.:.|.  ..|..|..:.:|.|...:..|..           ::...::.|.::.:|:.::
Human  1240 HRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAIL 1304

  Fly  1274 YCQHRCQLIRRASK-----LARMQDELAALPE---------------GYITPNR----------- 1307
            ..:::....|:.|:     |....|.....|:               |..:|.|           
Human  1305 LYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLS 1369

  Fly  1308 --PVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSRF 1370
              |:.:.|.:||...:.|:...:.|:|:|.: ..|:......:||..|:||||:.|::.|||||.
Human  1370 HPPIPIADMAEHTERLKANDSLKLSQEYESI-DPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 1433

  Fly  1371 KLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGR 1435
            .|||::...|||||||||:.|:.....:|.|||||..|..:||||.||..|..|||:||..||.|
Human  1434 ILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSR 1498

  Fly  1436 EKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRN--CESRIMRHFHFTTWPDFGVPE 1498
            .||||||| :|....||.|:|.|:.......:.:..|.:.:|  .|.|.:|.|.||.|||.||||
Human  1499 IKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPE 1562

  Fly  1499 PPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAMRKE 1563
            .|...:.|:|..:.....|..||:|||||||||:|.||.:|.:|:.|.....||::|.|..||.:
Human  1563 YPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQ 1627

  Fly  1564 RVFMVQTEQQYVCIHQCLL-AVLEGKEHLLADSLELH------ANDGYEVTKIYLE--RQPQTKM 1619
            |.:|||||.||..||:.|| ||..|...:.|.||..:      ...|..||.:.||  |...:|.
Human  1628 RNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKA 1692

  Fly  1620 GTLPIRASLAMAEKLDADLMTNK 1642
            .|         :..:.|:|..||
Human  1693 HT---------SRFISANLPCNK 1706

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp4ENP_001162669.1 FN3 151..242 CDD:238020 24/96 (25%)
fn3 247..328 CDD:278470 14/106 (13%)
fn3 343..417 CDD:278470 18/97 (19%)
fn3 443..525 CDD:278470 20/86 (23%)
FN3 548..611 CDD:238020 16/77 (21%)
FN3 620..706 CDD:238020 17/89 (19%)
fn3 708..796 CDD:278470 18/105 (17%)
fn3 824..886 CDD:278470 9/64 (14%)
fn3 902..978 CDD:278470 17/79 (22%)
fn3 1013..1092 CDD:278470 20/95 (21%)
UP_III_II 1106..>1248 CDD:297589 42/218 (19%)
PTPc 1329..1582 CDD:214550 117/254 (46%)
PTPc 1355..1582 CDD:238006 110/228 (48%)
PTPRSNP_002841.3 Ig 32..120 CDD:299845
I-set 33..124 CDD:254352
Important for binding to glycosaminoglycan chains. /evidence=ECO:0000250|UniProtKB:B0V2N1 68..72
IG_like 141..234 CDD:214653 30/170 (18%)
Ig2_RPTP_IIa_LAR_like 152..235 CDD:143215 28/139 (20%)
IG_like 251..328 CDD:214653 16/89 (18%)
Ig3_RPTP_IIa_LAR_like 259..327 CDD:143216 14/67 (21%)
FN3 332..421 CDD:238020 19/105 (18%)
FN3 428..520 CDD:238020 25/103 (24%)
FN3 525..613 CDD:238020 21/89 (24%)
FN3 621..715 CDD:238020 23/144 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 700..724 6/32 (19%)
FN3 723..828 CDD:238020 31/151 (21%)
FN3 838..920 CDD:238020 19/81 (23%)
FN3 932..1029 CDD:238020 20/96 (21%)
FN3 1037..>1097 CDD:238020 9/59 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1340 5/28 (18%)
PTPc 1392..1647 CDD:214550 118/256 (46%)
PTPc 1418..1647 CDD:238006 111/229 (48%)
Substrate binding. /evidence=ECO:0000250 1589..1595 5/5 (100%)
PTPc 1679..1938 CDD:214550 9/37 (24%)
PTPc 1708..1938 CDD:238006
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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