Protein Alignment Ptp4E and PTPRN2

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_001295197.1
• Gene: PTPRN2 / 5799
• HGNCID: 9677
• Length: 1038
• Species: Homo sapiens
• Alignment Length: 1032
• Identity: 242/1032 - (23%)
• Similarity: 378/1032 - (36%)
• Gaps: 274/1032 - (26%)

  Fly   735 VDFYTLKWWP------------------TDEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYR 781
            :|||..:..|                  |.::|..::....:|.||....:|.| |..||.|..:
Human    90 MDFYRYEVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRP-EASSPARPSK 153

  Fly   782 FEVQASSNGIRSGTTHLST---RTMPLIQ-------SDVFIANAGHE-----QGQD--------- 822
            ..|.:.....|.|...|:.   |.:|.::       |||.......:     :|.|
Human   154 HSVGSERRYSREGGAALANALRRHLPFLEALSQAPASDVLARTHTAQDRPPAEGDDRFSESILTY 218

  Fly   823 --ETITLSYTPTPADSTRFDIYRFSMGDPTIKDKE---KLANDTERKLSFSGLTPGKLYNVTVWT 882
              .|..|:|.|......|.|:...::|.  ::..|   |:.:..:|....:.|:   .|......
Human   219 VAHTSALTYPPGSRTQLREDLLPRTLGQ--LQPDELSPKVDSGVDRHHLMAALS---AYAAQRPP 278

  Fly   883 VSGGVASLPVQRLYRL---HPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQ- 943
            ...|..||..|.|.|.   .|.|:....|.|        .|.:|.|            |.|.|.
Human   279 APPGEGSLEPQYLLRAPSRMPRPLLAPAAPQ--------KWPSPLG------------DSEDPSS 323

  Fly   944 ---------LLQNVTKN-------TEITLQGLRPYHNYTFTVVVRSGSIQGTDF----------- 981
                     ||:::.:.       :.:.|.|:         ..:.:|.:||.|.
Human   324 TGDGARIHTLLKDLQRQPAEVRGLSGLELDGM---------AELMAGLMQGVDHGVARGSPGRAA 379

  Fly   982 -------ADVSVSTLMRSSAP-----------------ISASYQTLTAP------PGKVDYFQPS 1016
                   ||...:||...|.|                 :||:...|...      ||.:.:.:|.
Human   380 LGESGEQADGPKATLRGDSFPDDGVQDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARPL 444

  Fly  1017 DVQPGEVTF-EWSLEPAEQHGPIDYFRITCQN-ADDAADVSSYEFPVNATQGKIDGLVPGNHYIF 1079
            |::..:... |.||...|:...::  .:..|. :.|......:..|..|..|::...:||..
Human   445 DMERKKSEHPESSLSSEEETAGVE--NVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPS--- 504

  Fly  1080 RIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTI 1144
              :.:.:|..||:......:.:...|..|.:...:...|.....|...|
Human   505 --KEEQSLPAGAQEALSDGLQLEVQPSEEEARGYIVTDRDPLRPEEGRR---------------- 551

  Fly  1145 IIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPF-LTSNGSRKSSLEAEHFTIGTANCDK 1208
             :.|||   |..|::||       :.:...:.:.|...| :::|....::.:.|..|:.  |.||
Human   552 -LVEDV---ARLLQVPS-------SAFADVEVLGPAVTFKVSANVQNVTTEDVEKATVD--NKDK 603

  Fly  1209 HQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLVAMVLV-- 1271
            .:.......|:.|...:.|::            :..|...:...|..:|.|:.::..:..||:
Human   604 LEETSGLKILQTGVGSKSKLK------------FLPPQAEQEDSTKFIALTLVSLACILGVLLAS 656

  Fly  1272 -VVYC-----QHRCQLIRRASKLA-----------------RMQDELAALPEGYIT--------- 1304
             ::||     |||  |..:.|.|.                 ||.......|||..|
Human   657 GLIYCLRHSSQHR--LKEKLSGLGGDPGADATAAYQELCRQRMATRPPDRPEGPHTSRISSVSSQ 719

  Fly  1305 ------------------PNRPVHVK-DFSEHYRIMSADSDF-----RFSEEFEELKHVGRDQAC 1345
                              ...||... |.|..:.|:|...|.     |..:|:|.|.....:...
Human   720 FSDGPIPSPSARSSASSWSEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNS 784

  Fly  1346 SF-ANLPCNRPKNRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPRE--FIVTQGPLHS 1407
            || |....|.||||...:|.|||||..|:..:....||||||:.:..|: ||.  :|.|||||.:
Human   785 SFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHD-PRNPAYIATQGPLPA 848

  Fly  1408 TREEFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEF 1472
            |..:||:|.|||....|||||...|.|..:|..||| |..:..|...:|.|:.:   |.| ..:|
Human   849 TVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWP-DEGSNLYHIYEVNLVSE---HIW-CEDF 908

  Fly  1473 MVS-------RNCESRIMRHFHFTTWPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVG 1530
            :|.       :..|:|.:..|||.:|.|.|||...:||:.|.|...........|||||||.|.|
Human   909 LVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAG 973

  Fly  1531 RSGTFIALDRILQHIHK-SDYVDIFGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE 1586
            ||||::.:|.:|..:.| :..:||...:..:|.:|..||||::|:   ...|.||.|
Human   974 RSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQF---EFALTAVAE 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	5/31 (16%)
		fn3	708..796	CDD:394996	18/78 (23%)
		fn3	902..978	CDD:394996	14/92 (15%)
		fn3	1013..1092	CDD:394996	15/80 (19%)
		PTP_tm	1127..1247	CDD:465889	20/120 (17%)
		R3-PTPc	1358..1579	CDD:350396	88/230 (38%)
PTPRN2	NP_001295197.1	RESP18	98..>152	CDD:464394	12/54 (22%)
		Receptor_IA-2	532..620	CDD:463293	20/116 (17%)
		R-PTP-N2	750..1032	CDD:350458	106/287 (37%)