Protein Alignment Ptp4E and PTPRN

DIOPT Version :10

• Sequence 1: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Sequence 2: NP_002837.1
• Gene: PTPRN / 5798
• HGNCID: 9676
• Length: 979
• Species: Homo sapiens
• Alignment Length: 1202
• Identity: 268/1202 - (22%)
• Similarity: 396/1202 - (32%)
• Gaps: 450/1202 - (37%)

  Fly   532 RP----AAPLIQELRSIDQGLM---LSWRSDVNSRQDRYEVHYQ----------------RNGTR 573
            ||    .:|::|.|:.:.:.||   |||..|:.    :|.:..:                |:|..
Human    70 RPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLT----QYVISQEMERIPRLRPPEPRPRDRSGLA 130

  Fly   574 EERTMATNETSLTIHYLHPGSGYEVKVHAISHGVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVL 638
            .:|               ||...|:.:..|..|  |.|.:  |...|:||..
Human   131 PKR---------------PGPAGELLLQDIPTG--SAPAA--QHRLPQPPVG------------- 163

  Fly   639 HWQAPEGSDFSEYVVRYRTDASPWQRISGLHENEARIKDMHYGERYLVQVNTVSFGVESPHPLEL 703
              :...|:..|         .||.|                               .|...||..
Human   164 --KGGAGASSS---------LSPLQ-------------------------------AELLPPLLE 186

  Fly   704 NVTMPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVR 768
            ::.:||||                 |.|       :|.:.|.                |..|
Human   187 HLLLPPQP-----------------PHP-------SLSYEPA----------------LLQP--- 208

  Fly   769 IPIEDLSPGRQYRFEVQASSNGIR--SGTTHL-STRTMPLIQS----------DVFIANAGHEQG 820
                       |.|....|.:|.|  .|:..: |...:|..::          .:|..:.||..|
Human   209 -----------YLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEAPALFSRTASKGIFGDHPGHSYG 262

  Fly   821 -----------QDETITLSYTPTPADSTRFDIYRF--------SMGDPTIKDKEKLANDTERKLS 866
                       ||..:.......||.| |..:.|.        :...|...:||.|.:..|:..|
Human   263 DLPGPSPAQLFQDSGLLYLAQELPAPS-RARVPRLPEQGSSSRAEDSPEGYEKEGLGDRGEKPAS 326

  Fly   867 FSGLTPGKLYNVTVWTVSGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFE 931
                 |....:..:..::..:|...|: |.:|.|..:|.|         :||....|.|...:
Human   327 -----PAVQPDAALQRLAAVLAGYGVE-LRQLTPEQLSTL---------LTLLQLLPKGAGRN-- 374

  Fly   932 LQYLSADEEAPQLLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPI 996
                      |..:.||..:.:.|::                |.::|.|.|::...|......|
Human   375 ----------PGGVVNVGADIKKTME----------------GPVEGRDTAELPARTSPMPGHP- 412

  Fly   997 SASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPV 1061
                   ||.|      ..|:||  :|....|.||.:...|                      ||
Human   413 -------TASP------TSSEVQ--QVPSPVSSEPPKAARP----------------------PV 440

  Fly  1062 NATQGKIDGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILA-PPVPEPS-------VT---PLE 1115
            ...               .::.||.||        |:.|.:| .|...|:       ||   ||.
Human   441 TPV---------------LLEKKSPLG--------QSQPTVAGQPSARPAAEEYGYIVTDQKPLS 482

  Fly  1116 VSRTSSTIEI-----SFRQGYFSNAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQ 1175
            ::.....:||     ....|.|.|...:..:.|..|..    |...|.:..          :..|
Human   483 LAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRH----NEQNLSLAD----------VTQQ 533

  Fly  1176 AIEPYNPFLTSNGSRKSSLEAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDT 1240
            |           |..||.|||             |.|.  ..|:.|...|.:..|...:...:.:
Human   534 A-----------GLVKSELEA-------------QTGL--QILQTGVGQREEAAAVLPQTAHSTS 572

  Fly  1241 VYSSPITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDE--LAAL-PEG- 1301
            ...|.:.|      :||....|.||||:.:.:...||           ||.||:  |||| |||
Human   573 PMRSVLLT------LVALAGVAGLLVALAVALCVRQH-----------ARQQDKERLAALGPEGA 620

  Fly  1302 ---------------YIT---------PNRPVHVK------------------------------ 1312
                           ..|         |..|..|.
Human   621 HGDTTFEYQDLCRQHMATKSLFNRAEGPPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQA 685

  Fly  1313 --DFSEHYRIMSADSDF-----RFSEEFEEL-KHVGRDQACSFANLPCNRPKNRFTNILPYDHSR 1369
              |.|..:.|::...|.     |.::|::.| .:......|:.|....|..|||..:.|||||:|
Human   686 NMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHAR 750

  Fly  1370 FKLQPVDDDDGSDYINANYMPGHNSPR--EFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFE 1432
            .||:.......||||||:.:..|: ||  .:|.|||||..|..:||:|.|||....|||||...|
Human   751 IKLKVESSPSRSDYINASPIIEHD-PRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVE 814

  Fly  1433 KGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVS-------RNCESRIMRHFHFTT 1490
            .|.::||:||| |..|..|...:|.|:.:   |.| ..:|:|.       :..|:|.:..|||.:
Human   815 DGVKQCDRYWP-DEGASLYHVYEVNLVSE---HIW-CEDFLVRSFYLKNVQTQETRTLTQFHFLS 874

  Fly  1491 WPDFGVPEPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKS-DYVDIF 1554
            ||..|.|...:.|:.|.|...........|||||||.|.||:||:|.:|.:|..:.|. ..:||.
Human   875 WPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIA 939

  Fly  1555 GIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE 1586
            ..:..:|.:|..:|:::.|:   ...|.||.|
Human   940 ATLEHVRDQRPGLVRSKDQF---EFALTAVAE 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	42/239 (18%)
		fn3	708..796	CDD:394996	16/89 (18%)
		fn3	902..978	CDD:394996	11/75 (15%)
		fn3	1013..1092	CDD:394996	14/78 (18%)
		PTP_tm	1127..1247	CDD:465889	22/119 (18%)
		R3-PTPc	1358..1579	CDD:350396	86/230 (37%)
PTPRN	NP_002837.1	RESP18 homology domain	35..131		14/64 (22%)
		RESP18	60..160	CDD:464394	24/112 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..173		16/103 (16%)
		PHA03247	<234..468	CDD:223021	62/338 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	289..329		10/45 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..439		16/83 (19%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000269|PubMed:25561468	449..575		35/173 (20%)
		Receptor_IA-2	469..557	CDD:463293	25/127 (20%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000250|UniProtKB:P80560	601..732		26/141 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	643..680		3/36 (8%)
		R-PTP-N	693..973	CDD:350457	100/285 (35%)